HLA-DQ
HLA-DQ β1 alleles associated with Epstein-Barr virus (EBV) infectivity and EBV gp42 binding to cells
... utilize HLA class II to facilitate entry and ...which HLA-DQ alleles are associated with EBV infectivity or resistance to EBV infection is important to better understand how the virus has evolved ...
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Association of IL-4RA single nucleotide polymorphisms, HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthma
... of HLA-DR HLA-DP, and HLA-DQ in Alternaria-sensitive moder- ate-severe asthmatics (Table ...of HLA- DP were not significantly different comparing the groups (data not ...The ...
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Analysis of HLA DR, HLA DQ, C4A, FcγRIIa, FcγRIIIa, MBL, and IL 1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcγRIIa R/R and IL 1Ra 2/2 genotypes on disease susceptibility
... les have been suggested as a minor risk factor in suscepti- bility to SLE in several populations [8,10,12]. Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring com- petitive inhibitor of IL-1. The IL-1Ra ...
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HLA DQ A1, DQB1 AND –DRB1 Gene Polymorphism In Malay Type 1 Diabetes Mellitus Patients and Their Use For Risk Prediction
... both HLA-DQ and HLA-DR allele frequencies in a large number of Malay patients, with type 1 DM and control ...the HLA complexes in type 1 DM susceptibility within the ...the HLA-markers ...
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Short ragweed allergen induces eosinophilic lung disease in HLA DQ transgenic mice
... This research was supported by National Institutes of Health grant AI-14764 and by funds from Boehringer Ingelheim Phar- maceuticals Inc. The immunostaining for mouse MBP was done in the Dermatology Research Laboratory ...
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A new model defines the minimal set of polymorphism in HLA-DQ and -DR that determines susceptibility and resistance to autoimmune diabetes
... the HLA with autoimmune diabetes is the β 57 hypothesis ...in HLA-DQ, to Ala, Val or Ser, with susceptibility to ...in HLA alleles of diabetics [20-22]. DR and DQ loci are in tight ...
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The increased ability to present citrullinated peptides is not unique to HLA SE molecules: arginine to citrulline conversion also enhances peptide affinity for HLA DQ molecules
... of HLA-DR (HLA-DRB1) and the alpha and beta chain of HLA-DQ (HLA-DQA1 and HLA-DQB1) that are inherited together in ...the HLA-DRB1 locus, in par- ticular by those alleles ...
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Molecular cloning of a polymorphic DNA endonuclease fragment associates insulin dependent diabetes mellitus with HLA DQ
... an HLA-DQ beta-chain complementary DNA (cDNA) probe and negatively associated with insulin-dependent diabetes mellitus (IDDM) was cloned and sequenced to localize the polymorphism to BamHI sites in ...
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A functional analysis of HLA-DQ using transgenic models
... of HLA class II isotype expression were similar in CD2+, CD4+ and CD8+ subgroups of T ...1979). HLA-DR, -DQ and -DP molecules are differentially expressed on T cells after stimulation (Robbins e ta ...
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A combination of HLA DQ beta Asp57 negative and HLA DQ alpha Arg52 confers susceptibility to insulin dependent diabetes mellitus
... Asp57-negative DQ beta chain, but also introduces the possibility that a DQ alpha chain bearing an arginine in position 52 (Arg52) confers susceptibility to ...a DQ alpha-chain bearing an Arg52 and a ...
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HLA DR and HLA DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance
... the HLA varia- bles and the occurrence of leprosy per se and the LL and TT subgroups, was performed using the Chi square test, with the Yates's correction or Fisher's Exact Test when neces- sary, using the Graph ...
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Profile Of Hla-Dq Allele In A Sample Of Iraqi Celiac Disease Patients.
... The association between disease and genetic factor is generally expressed in terms of a relative risk value (RR). The level of significance (probability) is calculated by Fisher’s exact probability (P) through ...
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HLA DQ gene complementation and other histocompatibility relationships in man with the anti Ro/SSA autoantibody response of systemic lupus erythematosus
... A DQ alpha RFLP associated with HLA-DQ1 and a DQ beta RFLP associated with HLA-DQ2 predict that the alpha beta heterodimer in HLA- DQ1/DQ2 heteroxygotes is most closely related to ...
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Identification and characterization of autoreactive T cell responses to bullous pemphigoid antigen 2 in patients and healthy controls
... the HLA-DQB1*0301 allele showed primary T cell responses to ...carried HLA-DQ alleles other than DQB1*0301 did not mount significant primary T cell re- sponses to ...the HLA- DQB1*0301 allele ...
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... viduals. HLA-DQ2 protein encoded by HLA-DQA1*05 and DQB1*02 alleles is found in 90-95% of CD ...carry HLA-DQ8 protein encoded by HLA-DQA1*03 and DQB1*03:02 ...Specific HLA-DQ ...
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Vaginal Langerhans Cells Nonproductively Transporting HIV-1 Mediate Infection of T Cells
... A Cells emigrating from vaginal epithelial sheets challenged ex vivo with HIV-1BaL were stained with anti-CD4 PE, anti-CD8 PE-Cy5, and anti-HLA-DQ FITC BD Biosciences and sorted into a p[r] ...
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Cell surface MHC density profiling reveals instability of autoimmunity associated HLA
... of HLA-DQ ...among HLA-DQ alleles, indicating a dynamic allelic hierarchy in the intrinsic stability of HLA-DQ ...risk–associated HLA-DQ haplotypes, which also ...
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HLA DQB1 polymorphism determines incidence, onset, and severity of collagen induced arthritis in transgenic mice Implications in human rheumatoid arthritis
... Certain HLA-DR alleles have been associated with predis- position to human rheumatoid arthritis ...certain HLA-DQ alleles may also be important in determining susceptibility to ...for HLA-DQ8, ...
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Gamma interferon induces different keratinocyte cellular patterns of expression of HLA DR and DQ and intercellular adhesion molecule I (ICAM I) antigens
... In normal skin, both HLA-DR and HLA-DQ are found on the same cells, namely vascular endothelium,** Langerhans cells'* and the acrosyringial epithelium.'^ Under normal circumstances neith[r] ...
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HLA Class II Profile and Distribution of HLA-DRB1 and HLA-DQB1 Alleles and Haplotypes among Lebanese and Bahraini Arabs
... example, HLA-DRB1, with more than 315 known alleles, and DPB1, with more than 99 alleles (19), represent the most polymorphic protein-encod- ing regions of the human genome (19, ...
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