host shutoff
KSHV SOX mediated host shutoff: the molecular mechanism underlying mRNA transcript processing
... of host (and viral) mRNA transcripts in a process termed host ...in host shutoff. Our results further con- firm that SOX and the host exoribonuclease Xrn1 act in concert to elicit the ...
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Herpes Simplex Virus Virion Host Shutoff Attenuates Establishment of the Antiviral State
... virion host shutoff protein (vhs), while being nonessential for replication cell in culture, is a crucial factor for both HSV type 1 (HSV-1) and HSV-2 replication, virulence, and pathogenesis in vivo (35, ...
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Ribosome Profiling Reveals Translational Upregulation of Cellular Oxidative Phosphorylation mRNAs during Vaccinia Virus-Induced Host Shutoff
... inhibits host cell transcription ...VACV-induced host shutoff that results in similar reductions of ribosome-associated cellular ...VACV-induced host shutoff may not be able to ...
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Evidence for Translational Regulation by the Herpes Simplex Virus Virion Host Shutoff Protein
... virion host shutoff protein (vhs) encoded by gene UL41 is an mRNA-specific RNase that triggers accelerated degradation of host and viral mRNAs in infected ...
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mRNA Degradation by the Virion Host Shutoff (Vhs) Protein of Herpes Simplex Virus: Genetic and Biochemical Evidence that Vhs Is a Nuclease
... virion host shutoff (Vhs) protein (UL41) of herpes simplex virus destabilizes both host and viral ...from host to viral gene expression and facilitates the sequential expression of different ...
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Herpes Simplex Virus Virion Host Shutoff (vhs) Activity Alters Periocular Disease in Mice
... rapid shutoff of macromolecular synthesis in infected ...this shutoff is the product of the UL41 gene, known as the virion host shutoff (vhs) protein (21, 33, ...vhs-induced shutoff ...
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Expression and function of the equine herpesvirus 1 virion-associated host shutoff homolog.
... repress host cell protein synthesis early in infection has been studied extensively and found to involve the activities of the UL41 gene product, the virion-associated host shutoff (vhs) ...early ...
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The herpes simplex virus virion host shutoff function.
... The lack of host shutoff at an input MOI of 2 PFU of KOS virus in the presence of dactinomycin per cell was also observed in additional experiments in which the level of host cell protei[r] ...
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The Virion Host Shutoff Endonuclease (UL41) of Herpes Simplex Virus Interacts with the Cellular Cap-Binding Complex eIF4F
... virion host shutoff (Vhs) (UL41) endonuclease is a component of herpes simplex (HSV) virions (2, 4, 26, 27, 32, 42) that, during lytic infections, accelerates the turnover of many host and viral ...
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Site-Directed Mutagenesis of the Virion Host Shutoff Gene (UL41) of Herpes Simplex Virus (HSV): Analysis of Functional Differences between HSV Type 1 (HSV-1) and HSV-2 Alleles
... The transient-expression assay of UL41 activity offers this advantage. Nevertheless, the results from these experiments should be interpreted with the caveat that, because different transfected UL41 alleles may express ...
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Role of the VP16-Binding Domain of vhs in Viral Growth, Host Shutoff Activity, and Pathogenesis
... virion host shutoff (vhs) protein of herpes simplex virus type 1 causes the degradation of host and viral mRNA immediately upon infection of permissive ...
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Pathogenesis of Herpes Simplex Virus Type 2 Virion Host Shutoff (vhs) Mutants
... Herpes simplex virus (HSV) induces a rapid destabilization of mRNA due to the product of the viral UL41 gene, known as the virion host shutoff (vhs) protein. This 58-kDa phosphopro- tein, packaged within ...
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Role of Herpes Simplex Virus ICP27 in the Degradation of mRNA by Virion Host Shutoff RNase
... (virion host shutoff [VHS]) that is carried by the virion into the infected cell and causes the shutoff of host protein synthesis was first reported by Frenkel and coworkers in the late 1980s ...
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The Virion Host Shutoff Protein (UL41) of Herpes Simplex Virus 1 Is an Endoribonuclease with a Substrate Specificity Similar to That of RNase A
... S-transferase–virion host shutoff (GST-vhs) protein exhibited endoribonucleolytic activity in in vitro assays using as substrates in vitro-transcribed regions of IEX-1 ...
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Host Shutoff Is a Conserved Phenotype of Gammaherpesvirus Infection and Is Orchestrated Exclusively from the Cytoplasm
... We therefore predicted that MHV68 muSOX would also exhibit partial cytoplasmic localization, which might be integral to its host shutoff function. Indeed, similar to its KSHV and EBV homologs, HA-tagged ...
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Herpes simplex virus VP16 forms a complex with the virion host shutoff protein vhs.
... 2339 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Herpes simplex virus HSV virions contain at least two regulatory proteins that modulate gene expression in infected [r] ...
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Herpes simplex virus virion host shutoff function.
... KRUPER, AND NIZA FRENKELt* Department of Molecular Genetics and Cell Biology, the University of Chicago, Chicago, Illinois 60637 Received 14 August 1987/Accepted 2 December 1987 Infectio[r] ...
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Control of mRNA stability by the virion host shutoff function of herpes simplex virus.
... The first demonstration that the vhsl mutation affects the half-lives of viral as well as host mRNAs was provided by the observation that, following reversal of a cycloheximide block pre[r] ...
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Characterization of a temperature-sensitive mutant of vaccinia virus reveals a novel function that prevents virus-induced breakdown of RNA.
... At 40°C, ts22 showed a pattern of viral protein synthesis indistinguishable from that observed in WT-infected cells until 8 h postinfection, including host shutoff, synthesis and shutoff[r] ...
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Involvement of the Interferon-Regulated Antiviral Proteins PKR and RNase L in Reovirus-Induced Shutoff of Cellular Translation
... in host shutoff ...the host shut- off phenotype characteristic of this strain was largely abolished in PKR KO ...in host shutoff in PKR KO MEFs, although not to the same extent as in wt ...
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