HSV-1 and HSV-2
Comparison of the Host Immune Response to Herpes Simplex Virus 1 (HSV-1) and HSV-2 at Two Different Mucosal Sites
... type 1 and 2 infections among patients diagnosed with genital herpes FIG 4 Chemokine expression levels in mice genitally infected with HSV-2 correlate with viral ...with HSV-1 ...
5
Protection Provided by a Herpes Simplex Virus 2 (HSV-2) Glycoprotein C and D Subunit Antigen Vaccine against Genital HSV-2 Infection in HSV-1-Seropositive Guinea Pigs
... virus 1 (HSV-1)-seropositive guinea pigs immunized and subsequently challenged intravaginally with ...study 1, HSV-2 glycoproteins C (gC2) and D (gD2) were produced in ...
11
Site-Directed Mutagenesis of the Virion Host Shutoff Gene (UL41) of Herpes Simplex Virus (HSV): Analysis of Functional Differences between HSV Type 1 (HSV-1) and HSV-2 Alleles
... of HSV-1 (strain KOS) is depicted by the open rectangle at the top of the ...acids 1 to 135, 208 to 243, and 365 to 489) with the corresponding regions of the HSV-2 (strain 333) ...
13
Regional Distribution of Antibodies to Herpes Simplex Virus Type 1 (HSV 1) and HSV 2 in Men and Women in Ontario, Canada
... to HSV-1 and that sero- prevalence increased to 89% among individuals in their early ...contrast, HSV-2 antibodies were not often found among individuals aged 15 to 16 years (0 to ...of ...
6
Different Mechanisms Regulate Productive Herpes Simplex Virus 1 (HSV-1) and HSV-2 Infections in Adult Trigeminal Neurons
... the HSV-2 LAT region (promoter, exon 1, and ...from HSV-1 (10). HSV-2/LAT1 preferentially establishes latency in A5⫹ neurons in vivo, suggesting that HSV-1 ...
5
Mutational analysis of the virion host shutoff gene (UL41) of herpes simplex virus (HSV): characterization of HSV type 1 (HSV-1)/HSV-2 chimeras.
... the HSV virion host shutoff (Vhs) protein ...of HSV type 1 (HSV-1) strain KOS and HSV-2 strain 333 are 87% ...similarity, HSV-2 strains generally shut off ...
10
A Lentiviral Vector-Based, Herpes Simplex Virus 1 (HSV-1) Glycoprotein B Vaccine Affords Cross-Protection against HSV-1 and HSV-2 Genital Infections
... virus 1 (HSV-1) and ...genital HSV infection (10), with an increment of at least 30% in the last 25 years (22) and in spite of a possible reduction in recent years (66, ...within 2 to ...
12
Peptide sequences of glycoprotein G-2 discriminate between herpes simplex virus type 2 (HSV-2) and HSV-1 antibodies.
... types 1 (HSV-1) and 2 (HSV-2), are usually acquired early (HSV-1) or later (HSV-2) in ...primary HSV infection is followed by an established ...
5
Functional Comparison of Herpes Simplex Virus 1 (HSV-1) and HSV-2 ICP27 Homologs Reveals a Role for ICP27 in Virion Release
... an HSV-1 ICP27 null mutant when expressed in ...the HSV-1 null mutant ...the HSV-1 genome in place of the type 1 gene, the resulting mutant, known as K2F1, grows with WT ...
14
Efficacy of the Herpes Simplex Virus 2 (HSV-2) Glycoprotein D/AS04 Vaccine against Genital HSV-2 and HSV-1 Infection and Disease in the Cotton Rat Sigmodon hispidus Model
... against HSV-2 genital herpes was not consistent between phase 2 and phase 3 clinical trials (15, ...phase 2 studies found protection, albeit dependent on a variety of ...against ...
16
Herpes simplex virus infections among rural residents in eastern China
... Both HSV-1 and HSV-2 infections are known to be common throughout the world ...of HSV-1 infection and only limited estimates of HSV-2 infection among selected ...
6
The alpha sequence of the cytomegalovirus genome functions as a cleavage/packaging signal for herpes simplex virus defective genomes.
... Because of the short stretch of sequence homology with HSV a sequences described above and the previous experiments demonstrating cross complementation between HSV-1 and HSV-2 a sequence[r] ...
8
HSV-2 ΔgD elicits FcγR-effector antibodies that protect against clinical isolates
... single-cycle HSV-2 ΔgD-2 affords com- plete protection against a panel of genetically diverse HSV-1 and HSV-2 clinical isolates and prevents the establishment of latency ...
16
Characterization of Herpes Simplex Viruses Selected in Culture for Resistance to Penciclovir or Acyclovir
... 48 HSV type 1 (HSV-1) and HSV-2 isolates were selected after passage in the presence of increasing concentrations of PCV or ACV in MRC-5 ...
9
Resistance of herpes simplex virus type 2 to neomycin maps to the N-terminal portion of glycoprotein C.
... HSV-1 recombinants containing chimeric gC genes composed of HSV-1 and HSV-2 sequences were used to localize neomycin resistance within the N-terminal 223 amino acids of gC-2.. This regio[r] ...
8
Cervicovaginal Neutralizing Antibodies to Herpes Simplex Virus (HSV) in Women Seropositive for HSV Types 1 and 2
... type 1 (HSV-1) and HSV-2 of the immunoglobulin G (IgG) and IgA isotypes were detected in the cervicovaginal secretions (CVS) of 77 HSV-1- and ...
6
Differences in the Regulatory and Functional Effects of the Us3 Protein Kinase Activities of Herpes Simplex Virus 1 and 2
... virus 1 (HSV-1) and 2 (HSV-2) are serine/threonine protein kinases with amino acid sequences that are conserved in the subfamily Alphaherpesvirinae (6, 24, ...of ...
11
Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants.
... The experimental design used in these studies was similar to that used in mapping adenovirus templates 9, 25 and consisted of comparing the segregation patterns of polypeptides specified[r] ...
22
Isolation of a nucleocapsid polypeptide of herpes simplex virus types 1 and 2 possessing immunologically type-specific and cross-reactive determinants.
... Some of the antigens induced by HSV-1 and HSV-2 have been shown to possess cross-reactive determinants which react with antiserum against either HSV-1 or HSV-2, whereas other antigens po[r] ...
9
Determination of herpes simplex virus type specific antibodies by enzyme linked immunosorbent assay
... We determined type-specific antibodies to herpes simplex virus type 1 HSV-1 and type 2 HSV-2 by an indirect enzyme-linked immunosorbent assay, using as antigens HSV-1 glycoprotein gC-1 a[r] ...
5