Human Telomerase
Clinical significance of combined detection of human papilloma virus infection and human telomerase RNA component gene amplification in patients with squamous cell carcinoma of the esophagus in northern China
... of telomerase is closely associated with cell immortalization and the occurrence or development of malignant tu- ...integrity. Telomerase comprises hTERC, human telomerase reverse ...
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Expression Pattern of Alternative Splicing Variants of Human Telomerase Reverse Transcriptase (hTERT) in Cancer Cell Lines Was not Associated with the Origin of the Cells
... the human telomerase reverse transcriptase (hTERT), the catalytic subunit of ...between telomerase enzyme activity, the abundance of alternatively spliced variants of hTERT and doubling time of a ...
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Targeting Human Telomerase RNA via Biochemical and in vitro Selection Methods
... normal human cells there is little or no telomerase activity, whereas in 80% to 90% of tumor cells there is active enzyme (Neidle and Parkinson ...of telomerase in cancer is highlighted by its role ...
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Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas
... the human carcinoma samples, and it has been found to be useful as a prognostic indicator ...[3-5]. Telomerase activity is mainly regulated by human telomerase reverse tran- scriptase (hTERT), ...
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Diverse regulatory manners of human telomerase reverse transcriptase
... ening telomerase activity ...of human foreskin fibroblast cells ...increasing telomerase activity ...in telomerase activation and oncogenesis. Inhibition of telomerase by dephosphory- ...
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The MNS16A Tandem Repeats Minisatellite of Human Telomerase: Influence on Polycythaemia Vera susceptibility in Sudanese Patients
... Background: Telomerase is a reverse transcriptase enzyme that can elongate the TTAGGG repeats of telomeres in cells, where it is expressed to sustain cellular ...of telomerase include RNA subunit ...
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Human telomerase reverse-transcriptase promoter-controlled and herpes simplex virus thymidine kinase-armed adenoviruses for renal cell carcinoma treatment
... using human telomerase reverse transcriptase (hTERT)-controlled herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV) in the hTERT promoter-driven HSV-TK/ GCV suicide gene system was ...for ...
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The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells
... The telomerase holoenzyme is composed of a number of proteins involved in the assembly, processing and stability of the complex in vivo [reviewed in 5, ...reconstitute telomerase activity in vitro [7, ...by ...
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Telomerase Activation by Human Papillomavirus Type 16 E6 Protein: Induction of Human Telomerase Reverse Transcriptase Expression through Myc and GC-Rich Sp1 Binding Sites
... High-risk human papillomaviruses (HPVs) immortalize keratinocytes by disrupting the retinoblastoma protein (Rb)/p16 pathway and activating ...induces telomerase activity in human ...activates ...
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Genomic amplification of the human telomerase gene (hTERC) associated with human papillomavirus is related to the progression of uterine cervical dysplasia to invasive cancer
... Moreover, telomerase activity is dependent on the expression of 2 main core component genes, hTERT and ...addressing telomerase activity using TRAP assay [7,8], amplification of hTERC using in situ ...
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The correlations between DNA methylation and polymorphisms in the promoter region of the human telomerase reverse transcriptase (hTERT) gene with postoperative recurrence in patients with thyroid carcinoma (TC)
... man telomerase reverse transcriptase (hTERT) gene ...of telomerase catalytic activity, encodes the reverse transcriptase com- ponent of the telomerase complex, and its abnormity is considered to be ...
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Toll like receptor 3 activation selectively reverses HIV latency in microglial cells
... HIV: human immuno‑deficiency virus; TLRs: toll‑like receptors; CNS: central nervous system; HAND: HIV‑associated neurocognitive disorders; GFP: green fluorescence protein; Mtb: Mycobacterium tuberculosis; ...
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Immobilization-Free Strategies for Designing of DNA-Based Electrochemical Biosensors
... of telomerase activity is beneficial for early cancer diagnosis, prognosis, and cancer therapy ...of human telomerase activity (Figure 8) ...of telomerase, telomerase substrate (TS) ...
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Switching of mesodermal and endodermal properties in hTERT-modified and expanded fetal human pancreatic progenitor cells
... = human embryonic stem cells; HNF = hepatic nuclear factor; hTERT = human telomerase reverse transcriptase; hTERT-FPC = human telomerase reverse transcriptase containing fetal ...
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Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer
... follows: human telomer- ase RNA ( hTR ): 5 ’ -cgccttccaccgttcattc-3 ’ (sense, 400 nM), 5’-gctgacagagcccaactc-3’ (antisense, 400 nM), 5’-FAM- agctgctggcccgttcgccc-TAMRA-3’ (TaqMan Probe, 200 nM); human ...
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A place for precision medicine in bladder cancer: targeting the FGFRs
... Although these are not sufficient to induce cell transformation in human telomerase-immortalised normal urothelial cells TERTNHUC, expression of mutant FGFR3 stimulates continued prolife[r] ...
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umi-unc-1092.pdf
... In human telomerase, the same effect is seen as the Hsp90 interaction, but not the p23 interaction, is maintained with hTERT in the presence of GA (Holt et ...
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Signaling through estrogen receptors modulates telomerase activity in human prostate cancer
... to telomerase activation, an early event in prostate ...of human telomerase (hTERT) and telomerase activity were promptly induced in human prostate normal epithelial cells, fresh ...
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Telomerase expression in sebaceous lesions of the skin
... demonstrated telomerase expression in ophthalmologic sebaceous carcinoma and have suggested possible diagnostic utility in distinguishing these neoplasms from sebaceous ...evaluate telomerase expression via ...
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Identifying cancer-causing noncoding RNAs
... the human telomerase RNA (hTR) and the checkpoint kinase ...of telomerase activity and telomere length as it was observed in cells lacking hTERT, and in young primary human cells with ...
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