hydrophobic-core
Spiral search: a hydrophobic-core directed local search for simplified PSP on 3D FCC lattice
... In this paper, we present a novel spiral search algorithm for ab initio protein structure prediction using HP energy model on three-dimensional (3D) FCC lattice. By using tabu heuristic, the search approaches towards the ...
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Superparamagnetic Iron Oxide Nanoparticles: Amplifying ROS Stress to Improve Anticancer Drug Efficacy
... Figure 1A shows the transmission electron micros- copy (TEM) image of a representative SPION-micelle sample, where a cluster of SPIONs was encapsulated inside the hydrophobic core of p[r] ...
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Deconstructing the DGAT1 enzyme: membrane interactions at substrate binding sites
... the hydrophobic core of the system, while in the other binding site (Sit2), may involve an electrostatic attraction to negatively-charged membranes head ...
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Lipopolysaccharide is inserted into the outer membrane through an intramembrane hole, a lumen gate, and the lateral opening of LptD
... the hydrophobic core between the two b sheets (Okuda et ...the core of the N-terminal domain of LptD bind detergent molecules, C8E4 and LDAO, which are potential mimetics of lipid A (Figures 1A and ...
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An amino-terminal deletion mutation of pseudorabies virus glycoprotein gIII affects protein localization and RNA accumulation.
... The first six residues constitute a hydrophilic domain and are immediately followed by a hydrophobic core of amino acids 3565 Downloaded from http://jvi.asm.org/ on November 10, 2019 by [r] ...
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Dual self assembly of supramolecular peptide nanotubes to provide stabilisation in water
... A CP with two conjugation sites was chosen to provide a dense hydrophobic core region around the peptide to better exclude water molecules competing with the hydrogen bond stacking of the nanotubes. The ...
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Processing of Human Cytomegalovirus UL37 Mutant Glycoproteins in the Endoplasmic Reticulum Lumen prior to Mitochondrial Importation
... Based upon the presence of the UL37x3 consensus ER sig- nal peptidase I site and the sizes of gpUL37 cleavage products, we had predicted that the UL37 precursor would be cleaved between aa 193 and 194 (30). To determine ...
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Redundancy of signal and anchor functions in the NH2-terminal uncharged region of influenza virus neuraminidase, a class II membrane glycoprotein.
... On the basis of translocation and membrane stability data for different mutants, we suggest that the first 20 amino acid residues 7 to 27 are likely to provide the hydrophobic core for t[r] ...
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Amphiphilic Block Copolymer for adsorption of Organic Contaminants
... abundant hydrophobic spaces within the amphiphilic ...the core- organic complexes are effective in adsorption of vari- ous organic pollutants by hydrophobic ...the hydrophobic core of ...
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A nuclear magnetic resonance investigation of the role of structure and dynamics in the function of chymotrypsin inhibitor 2
... the hydrophobic core of chymotrypsin inhibitor 2, a protein chosen for its simplicity, in that it is neither classically allosteric nor an ...its hydrophobic core in the absence of significant ...
102
Platinum covalent shell cross-linked micelles designed to deliver doxorubicin for synergistic combination cancer therapy
... therapeutic drug was utilized as a cross-linker to construct a novel dual-drug co-delivery system for the combined delivery of DOX and Pt(IV). The amphiphilic diblock copo- lymer PCL-b-P(OEGMA-co-AzPMA) was synthesized, ...
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Loop B is a major structural component of the 5 HT3 receptor
... The models indicate that there is a hydrophobic core be- tween the inner and outer b sheets (Fig. 5, A and B). They also predict an extensive network of hydrogen bonds, both between loop B and adjacent ...
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Synthesis of Organic Dye Impregnated Silica Shell Coated Iron Oxide Nanoparticles by a New Method
... Abstract A new method for preparing magnetic iron oxide nanoparticles coated by organic dye-doped silica shell was developed in this article. Iron oxide nanoparticles were first coated with dye-impregnated silica shell ...
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Cosurim: A program for automated computation of composition of core, rim and surface of protein data bank files and its applications
... compact hydrophobic core, keeping the polar residues in the contact of bulk water in the surface of the protein that eventually takes a globular ...This hydrophobic collapse is an entropy driven and ...
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Development of a robust pH-sensitive polyelectrolyte ionomer complex for anticancer nanocarriers
... a hydrophobic PLA and a hydrophilic PEG to triblock copolyelectrolytes provided colloidal aggregation stability by forming a tight hydrophobic core and steric hindrance on the surface of PIC, ...
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Journal of Applied Pharmaceutical Science
... molecular core shell structure known as ‘polymeric ...with hydrophobic core shield from water by a mantle of hydrophilic ...the hydrophobic cores or can be linked covalently to component ...
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Inhibition of Human Immunodeficiency Virus Type 1 Infectivity by the gp41 Core: Role of a Conserved Hydrophobic Cavity in Membrane Fusion
... in hydrophobic cavities that are sur- rounded by different sets of ...gp41 core is un- likely to be a major cause of the fusion-defective phenotype of the mutant ...gp41 core plays a specific and key ...
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A Hydrophobic Binding Surface on the Human Immunodeficiency Virus Type 1 Nef Core Is Critical for Association with p21-Activated Kinase 2
... Nef core domain in a region distinct from the dimerization and SH3-binding ...Nef core domain structures demonstrates the proximity of amino acids important for Pak2 ...Nef core domain (light green) ...
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Regulated processing of hepatitis C virus core protein is linked to subcellular localization.
... of core protein, up to residue 164, result in the nuclear localization (16, 19, 23, ...between core protein proteolytic processing and its subsequent subcellular localization is still ...of core ...
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AN OVERVIEW ON SUSTAINED RELEASE ENTERIC COATED TABLET OF PENTOPRAZOLE
... containing core tablet (rapid release function), the press coated swellable hydrophobic polymer layer (Hydroxy propyl cellulose layer (HPC), time release function) and an enteric coating layer (acid ...
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