Hypoxic-Ischemic Brain Injury
Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury
... Concomitantly, post insult, we observed a decrease in Yme1L protein expression in vitro (Figure 3) and in vivo (Figure 4). It is well established that in animal models of HI and in vitro, the insult induces a rapid ...
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Progressive brain failure after diffuse hypoxic ischemic brain injury: a serial MR and proton MR spectroscopic study
... an hypoxic-ischemic brain injury that selectively involved the neuronal population during early phases: this is a unique pic- ture, very different from the experimental studies in which a ...
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Neonatal Hypoxic-Ischemic Brain Injury: Apoptotic and Non-Apoptotic Cell Death
... Figure 1: Neuronal cell death pathways in the neonatal hypoxic-ischemic brain injury. a. Necroptosis-Ligation of tumour necrosis factor receptor 1 (TNFR1) results in the recruitment of ...
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Early MR Features of Hypoxic ischemic Brain Injury in Neonates with Periventricular Densities on Sonograms
... We found an overall agreement between the lo- cations of the lesions on sonograms and on MR images, but the MR images showed more extensive lesions in the subcortical white matter and depicted lesions in other lobes. The ...
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Measurement of Lactate Content and Amide Proton Transfer Values in the Basal Ganglia of a Neonatal Piglet Hypoxic Ischemic Brain Injury Model Using MRI
... after hypoxic-ischemic brain injury, and investigate the non- invasive detection of intracellular pH in brain tissues are few but ...in hypoxic-ischemic ...
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Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two hit” model
... Hypoxic ischemic brain injury (HIBI) after cardiac arrest (CA) is a leading cause of mortality and long-term neurologic disability in ...secondary brain injury and neuronal cell ...
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Original Article Neuroprotective and regenerative effects of melatonin on hypoxic-ischemic brain injury in neonatal rats
... blood- brain barrier to enter the brain but can also penetrate the hypothalamus barrier, reaching the central nervous system, where it can pro- tect against various neurodegenerative dise- ases and ...
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Granulocyte Stimulating Factor Attenuates Hypoxic ischemic Brain Injury by Inhibiting Apoptosis in Neonatal Rats
... neonatal hypoxic-ischemic brain ...after hypoxic-ischemic insult, hypoxia-ischemia induced increase in TUNEL-positive cells, annexinV+/PI- and JC-1 positive apoptotic cells in the ...
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Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic ischemic brain injury
... neuronal injury at least part of which resembles programmed cell death, we ex- amined whether the caspase inhibitor BAF could provide neu- roprotection when administered in this injury ...of brain ...
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Ceftriaxone attenuates hypoxic-ischemic brain injury in neonatal rats
... in brain slides to reveal the regional differ- ence of GLT1 expression between ceftriaxone treated and saline ...of brain section (A,E: corpus callosum; B,F: cerebral cor- tex; C,G: hippocampus and D,H: ...
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Use of estetrol with other steroids for attenuation of neonatal hypoxic-ischemic brain injury: to combine or not to combine?
... developing brain as well as in adults brains mainly in the hippocampus [55, 56] with a significant binding properties at postnatal day 4 (P4) which declines to adult levels by P15 [57, ...the brain during ...
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Excitatory Amino Acids Contribute to the Pathogenesis of Perinatal Hypoxic Ischemic Brain Injury
... observations that intra-cerebral injection of the competitive EAA antagonist arninophosphonoheptanoic acid AP7 attenuated acute ischemic neuronal damage 3 and that preceding deafferentat[r] ...
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Individualized perfusion targets in hypoxic ischemic brain injury after cardiac arrest
... Although uniformly increased MAP targets seem in- tuitive to mitigate secondary injury in HIBI and are sup- ported by emerging observational literature, guideline statements recommend a MAP threshold of ≥ 65 mmHg ...
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Neonatal dexamethasone treatment exacerbates hypoxic-ischemic brain injury
... HI-induced brain injury is one of major causes of ...neonatal brain to subsequent HI ...neonatal brain against subsequent HI injury [15,16,34], our results do not support a ...
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Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia
... ischemia/reperfusion injury [9, ...perinatal hypoxic-ischemic brain injury ...neonatal hypoxic-ischemic brain ...
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The potential of erythropoietin to treat asphyxia in newborns
... neonatal hypoxic-ischemic brain injury, we can develop new neuroprotective strategies that promote or inhibit specific ...following injury, it is possible that, ultimately, a “cocktail” ...
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Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel?
... Perinatal hypoxic-ischemic encephalopathy (HIE) affects one to three per 1,000 live full-term births and can lead to severe and permanent neuropsychological sequelae, such as cerebral palsy, epilepsy, ...
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Cerebral palsy: MR findings in 40 patients
... Results: Review of MR scans of 11 patients who had been born prematurely revealed findings of periventricular white matter damage, indicative of hypoxic-ischemic brain injury 82%, the ch[r] ...
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TRPM7 inhibitor carvacrol protects brain from neonatal hypoxic-ischemic injury
... HI brain apoptosis ...from injury in neonatal HI brains ...neonatal hypoxic-ischemic brain ...of ischemic stroke ...HI brain injury ...neonatal ...
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Inhibition of miRNA-210 reverses nicotine-induced brain hypoxic-ischemic injury in neonatal rats
... of brain-derived neurotrophic factor (BDNF) and tropomyosin-related kinase isoform B (TrkB) in the neonatal brain was measured with Western blot analysis as described previously ...
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