IL-2R
A panel containing PD-1, IL-2Rα, IL-10, and CA15-3 as a biomarker to discriminate breast cancer from benign breast disease
... To the best of our knowledge, this study is the first to investi- gate the differential diagnostic efficiencies of immune check- point molecules in discriminating BC from BBD. Specifically, we combined immune molecules ...
13
Soluble IL 2R¿ (sCD25) Exacerbates Autoimmunity and Enhances the Development of Th17 Responses in Mice
... the IL-2R signalling complex on the cell surface are known to be required for efficient IL-2 binding and the subsequent activation of downstream signalling events [25], whether sCD25 has any ...
9
Cellular expression of interleukin 2 (IL-2) and its receptor (IL-2R, CD25) in lung tumours
... of IL-2 and of the subunit a of its receptor (IL-2Ra, CD25) in relation to the proliferative activity of various subtypes of lung ...of IL-2 was detected in all types of lung tu- ...of IL-2 ...
8
<p>Usefulness of Combined Measurement of Serum Soluble IL-2R and Angiotensin-Converting Enzyme in the Detection of Uveitis Associated with Japanese Sarcoidosis</p>
... lymphoma (stage III or IV) were significantly higher than those in patients with sarcoidosis. 13 It is, therefore, possible that intraocular lesions in patients with PIOL are too small and limited to high serum ...
7
Dexamethasone inhibits human interleukin 2 but not interleukin 2 receptor gene expression in vitro at the level of nuclear transcription
... the IL-2 gene but not that of the IL-2R ...inhibit IL-2R mRNA levels by 50%, whereas lower doses (10(-6) M) inhibited by greater than 70% the accumulation of IL-2 ...mRNA. ...
10
Characterization of Immunodeficiency in a Patient With Growth Hormone Insensitivity Secondary to a Novel STAT5b Gene Mutation
... Abbreviations: IL, interleukin; GH, growth hormone; JAK, Janus kinase; STAT, signal transducer and activator of transcription; GHR, growth hormone receptor; IL-2R, interleukin 2 receptor; Treg, ...
11
Interleukin 2 and interleukin 2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures
... of IL-2R mRNA and by immunofluorescence, IL-2R membrane ...of IL-2R with ACTH-positive cells and other cell types expressing the ...lymphocyte-produced IL-2, this cytokine ...
9
Monocytes are essential for inhibition of synovial T cell glucocorticoid mediated apoptosis in rheumatoid arthritis
... the IL-2R chain cytokines, such as IL-15 ...express IL-15 [24], a cytokine able to upregulate Bcl-2 expression [3] and to render activated T cells resistant to glu- cocorticoid-mediated ...
9
PP2A enables IL-2 signaling by preserving IL-2Rβ chain expression during Treg development
... surface IL-2Rβ and preserving the IL-2R signaling potency in ...mouse IL-2Rβ in PP2A-deficient Tregs can overcome the decreased expression of IL-2R and resume IL-2 ...of ...
12
The influence of human papillomavirus type and HIV status on the lymphomononuclear cell profile in patients with cervical intraepithelial lesions of different severity
... of IL-2R on keratinocytes and the IL-2 secretion has been reported in different phases of cancer cell development ...of IL-2 to IL-2R on tumour cells may down-regulate surface ...
9
Prolonged Viremia and Immune Response to Human Herpesvirus 7 in an Infant With Liver Dysfunction
... of IL-2R expression after HHV-6 antigen ...percentage IL-2R-positive cells after HHV-6 or HHV-7 antigen stimulation to control were , ...of IL-2R. According to the results of ...
5
v-rel induces expression of three avian immunoregulatory surface receptors more efficiently than c-rel.
... In this study, we demonstrated that three avian immunoregulatory receptors, major histocompatibility MHC antigens class I and class II as well as the interleukin-2 receptor IL-2R, were i[r] ...
12
Lymphocyte Modulation in a Baboon Model of Immunosenescence
... of IL-2, the most important cytokine for T cells, decline with age ...the IL-2R␣ in serum sharply decline with increasing age in our baboon model, to reach a minimum at about 5 years of age, whereas ...
6
Inhibition of T cell apoptosis in the rheumatoid synovium
... by IL-2R gamma chain signaling cytokines (which upregulate Bcl-2 and Bcl-XL) or by interaction with synovial fibroblasts (which upregulates Bcl-xL but not ...
9
Phenotype and Function of CD25 Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood
... CD25 − B cells from cord blood. We found that only a few percentages of the cord blood B cells (CBC) expressed CD25. However, they expressed the complete high-affinity IL-2R, and the receptor was fully ...
9
Development of a Macroarray To Specifically Analyze Immunological Gene Expression in Swine
... both IL-2 and the IL-2 receptor (IL-2R) in murine mixed leukocytes (20), human T cells (16), and porcine PBMCs (Table ...IFN-␥, IL-2, the IL-2R, TNF-␣, and CD40 in pig ...
8
Preclinical studies for a cationic liposome formulation containing Il-2 Intended for the treatment of Human Tumors
... if IL-2 by itself is known to remain in that cavity a liposome containing this growth factor could have an important cavity ...the IL-2R are known to strongly deplete IL-2 from the surrounding ...
9
X-linked severe combined immunodeficiency disease and the gamma c receptor component: prospects for molecular diagnosis.
... since IL-2 itself did not appear to be an essential component of this process (7, 31, ...of IL-2 knockout mice which lack the ability to produce IL-2 yet do not develop an XSCID-like immune ...
6
Age-Dependent Levels of Select Immunological Mediators in Sera of Healthy Children
... soluble IL-2R (sIL-2R) (sCD25), IL-6, IL-8, tumor necrosis factor alpha (TNF-a), soluble TNF receptor type II (sTNF-RII) (sCD120b), gamma interferon (IFN-g), soluble intercellular ...
5
Interleukin-2 Immunotherapy in Children
... JRA, juvenile rheumatoid arthritis; rIL-2, recombinant IL-2; NK, natural killer; IL-2R, IL-2 receptor.. In response to stimulation with antigens, acti-.[r] ...
9