Improved solubility
Novel Salt of Tinidazole with Improved Solubility and Antibacterial Activity
... low solubility and high permeability and is categorised into biopharmaceutics classification system (II), these physical properties prompts the researcher to investigate in finding out the new salts with ...
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SELF ASSEMBLED BIODEGRADABLE POLYMERIC NANOPARTICLES WITH IMPROVED SOLUBILITY OF CARVEDILOL: PREPARATION, CHARACTERISATION AND IN VITRO RELEASE KINETICS
... characteristics, improved solubility of incorporated drug and explored the prospects of manipulation and optimisation of the NPs for intended applications ...
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Naproxen-Gelucire Nanoformulations for Improved Solubility and Dissolution Rate of Poorly Water-Soluble Drug Naproxen
... Gelucires are amphiphilic pharmaceutical excipients that have been used as powerful solubilizing agents and bioavailability enhancers for orally and topically administered drugs. They are essentially saturated ...
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Improved fluorescence and solubility properties of N substituted carboxyl poly(1,8 diaminonaphthalene) in the presence of europium cations
... low solubility in the most polar solvents, except NMP, DMF and ...the solubility is primarily controlled by the molecular ...the solubility because the introduction of a carboxyl group on the ...
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Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells
... In summary, we developed a generic and versatile strategy to construct self-assembling CPT prodrugs with improved solubility, enhanced stability, and a high and fixed drug loading content. The payload and ...
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EFFECT OF THE PREPARATION OF SOLID DISPERSION METHOD ON THE SOLUBILITY AND CRYSTALLINITY OF SULFASALAZINE
... The solubility, dissolution and physicochemical properties of the sulfasalazine in the three solid dispersions were evaluated compared to drug powder using Scanning electron microscopy, differential scanning ...
7
The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.
... the improved solubility of compound 6 together with its synthetic tractability warrants additional SAR studies of other analogues ...significantly improved antiproliferative activities against ...
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“Design and Evaluation of Self-Emulsifying Drug Delivery Systems of Atazanavir Bi Sulfate” by Karunakara Reddy T, Yajaman Sudhakar, N. Devanna, India.
... in improved solubility, dissolution of the poorly water soluble drug Atazanavir, which a lipophilic drug and widely used in the treatment of ...HIV. Solubility of Atazanavir was determined in various ...
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“Formulation and Evaluation of Cefpodoxime Proxetil Dispersible Tablet” by Sushma Gupta, Pankaj Chandel, Kamaljeet Bagga, India.
... method. Out of all formulations (CPGT0%, CPT5%, CPGT2.5% and CPGT5%), tablets containing 5% w/w of CCS (CPGT 5%) showed least dispersion time (2.51 minutes) and highest drug release (98.09 % in 30 minutes) as compared to ...
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PREPARATION AND CHARACTERIZATION OF GLIPIZIDE SPHERICAL AGGLOMERATES BY DIRECT COMPRESSION METHOD USING DIFFERENT POLYMERS AND ITS EVALUATION
... with improved solubility, flow and compression characteristics by novel crystallization ...and improved micromeritic properties (bulk density, tapped density, compressibility index, angle of ...
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SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG ATORVASTATIN CALCIUM BY SOLID DISPERSION TECHNIQUE USING NATURAL CARRIER
... water solubility needs to be ...improve solubility and dissolution rate of ATC by formulating it into solid dispersion using maltose monohydrate as a highly water soluble ...showed improved ...
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2-Pyridylquinolone antimalarials with improved antimalarial activity and physicochemical properties
... A series of 2-pyridylquinolones has been prepared in 5-7 steps and through lead optimisation, antimalarial activity as low as 12 nM against Plasmodium falciparum (Pf) has been achieved. Compared with previous analogues ...
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Formulation and Evaluation of Pitavastatin Nanosuspension
... It is estimated that more than 1/3 of the compounds being developed by the pharmaceutical industry are poorly water soluble. The solubility/dissolution behavior of a drug is key factor to its oral bioavailability. ...
128
Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins
... Abstract: Icariin is a bioactive herbal ingredient isolated from Herba epimedii, which has been widely used for the treatment of osteoporosis and male sexual dysfunction in traditional Chinese medicine. The major ...
11
Examining the validity and reliability of the Activities Specific Balance Confidence Scale 6 (ABC 6) in a diverse group of older adults
... tems. 225 A gold nanoparticle-based colorimetric biosensor for sensitive and visual detection of sequence- specific DNA-binding protein has been documented. 226 Multifunctional gold nanoparticle dendrimer- based surface ...
165
<p>Electrosprayed Polymeric Nanospheres for Enhanced Solubility, Dissolution Rate, Oral Bioavailability and Antihyperlipidemic Activity of Bezafibrate</p>
... Solubility and oral bioavailability of poorly water- soluble substances can be ameliorated through fabrication of drug delivery systems such as nanoparticles, solid dis- persions, inclusion complexes with ...
11
MIDAZOLAM SOLUBILITY ENHANCEMENT PRE FORMULATION TECHNIQUES AT NASAL PHYSIOLOGICAL pH
... β-CDs consist of seven (α-1,4)-linked α-D- glucopyranose units. Cone-shaped CD molecules with hydrophilic outer surface and hydrophobic central cavity can take up a whole drug molecule, or more frequently some ...
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Solubility of Nutraceutical Compounds in Generally Recognized as Safe Solvents at 298 K - Volume 7 Number 5 (Oct. 2016) - IJCEA
... The solubility of quercetin and other flavonoids has been quantified in organic solvents such as acetonitrile, acetone and tert-amyl alcohol ...The solubility of quercetin in mixtures of water, methanol and ...
6
Liposomal Nanoformulation of Piperlongumine for Improved Aqueous Solubility and Enhanced Anti-tumour Activity In-vitro
... In this study, the first liposomal nanoformulation for the natural active compound PL was developed. The aqueous solubility issue of PL was successfully solved using liposomal nanotechnology. NanoPLs demonstrated ...
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Novel hybrids of natural β elemene bearing isopropanolamine moieties: synthesis, enhanced anticancer profile, and improved aqueous solubility
... The water solubility of 6a, 6q and β-elemene was determined by HPLC according to a previously published protocol [29]. Firstly, 10 mg of 6a, 6q or β-elemene was weighed and added to 1 mL of water, respectively. ...
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