In Silico
In silico information processing for DNA computing readout method based on DNA engine opticon 2 system
... Abstract--In this paper, a novel readout approach for the Hamiltonian Path Problem (HPP) in DNA computing based on the real-time polymerase chain reaction (PCR) is proposed. Based on this approach, real-time ...
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Antioxidant Activity and In Silico Analysis of Centella asiatica and Indigofera aspalathoides in Psoriasis
... From the analysis, ethanolic FSE extract showed better antioxidant scavenging activity. The bioactive compounds in the ethanolic FSE extract showed control in the growth of fibroblast by using cell viability assay and ...
10
Leishmania Proteomics: An in Silico Perspective
... We report on the state of the art of proteins recognized as potential targets for the development of leishmania treatments through the search of biologically active chemical species, either from experimental in vitro, in ...
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Leishmania Proteomics: an in silico perspective
... We report on the state of the art of proteins recognized as potential targets for the development of Leishmania treatments through the search of biologically active chemical species, either from experimental in vitro, in ...
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In Silico Modeling of C1 Metabolism
... in silico modeling of complex molecu- lar pathway ...In silico modeling of the individual and integrated C1 metabolism models enables the identification of the most sensitive parameters involved in the ...
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In silico discovery and in vitro activity of inhibitors against <em>Mycobacterium tuberculosis</em> 7,8-diaminopelargonic acid synthase (<em>Mtb</em> BioA)
... in silico drug property calculations have been utilized in this effort to discover new lead compounds against ...in silico absorption, distribution, metabolism, excretion, and toxicity ...
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In Silico Structural Characterization of Plasmodium Falciparum Helicase, PfBrr2
... in silico analysis and homology modeling method were used to characterize the physicochemical properties and 3D structure of PfBrr2 ...in silico tools and used for docking studies to understand protein- ...
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In vitro antimicrobial and α-glucosidase inhibitory potential of enantiopure cycloalkylglycine derivatives: Insights into their in silico pharmacokinetic, druglikeness, and medicinal chemistry properties
... in silico results indicate that all derivatives showed a resemblance with several parameters of the antimicrobial standards, especially in terms of molecular property, bioavailability, lipophilicity, medicinal ...
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Treatment of Gastric Ulcers with Fenugreek Seed Extract; In Vitro, In Vivo and In Silico Approaches
... The extract tested positive for the presence of flavonoids. The in vitro gastroprotective activity of fenugreek extract can be attributed to the free radical scavenging effect of the extract on the AGS cell line. The in ...
7
In silico screening of ligand databases: Methods and applications
... Pressure is mounting on the pharmaceutical industry to reduce both the cost of drugs and the time to market. The large number of targets made available in the last decade has created a new area for technologies that can ...
8
A kinetic platform for in silico modeling of the metabolic dynamics in <em>Escherichia coli</em>
... considered critical for its inclusion as an optimal candidate for designing drugs. The added feature that makes this simulation platform unique is its flexibility to incorporate different kinetic parameters or metabolite ...
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In silico cloning and bioinformatics study of Brucella melitensis Omp31 antigen in different mammalian expression vectors
... Abstract Brucella melitensis, as a pathogenic gram-negative intracellular bacterium, causes bru- cellosis in animals and humans. According to literature, the B. melitensis outer membrane protein 31 (Omp31) is considered ...
12
In Silico Antigenicity Screening of Moringa Coagulant
... Moringa coagulant (MC) obtained from the seeds of plant moringa oleifera (family- Moringaceae) has been substantially investigated for water purification, but, scarcely pharmaceutical applications. Recent investigations ...
6
IN-SILICO ANALYSIS OF ANDROGRAPHOLIDE AGAINST CANCER
... Cancer is the uncontrolled growth of abnormal cells in the body. It is the most serious disease on which extensive research is being done all over the world. Structure based drug designing offers a computational approach ...
6
Aloe Vera as an Antagonist for TNF Alpha: In Silico Study
... The current investigation aimed at assessing the inhibitory effects of Aloe vera phytochemicals against TNF-α using in-silico approach as it is rapid and cost effective. Molecular docking using Hex CUDA 8.0 server ...
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In silico analysis of the grapefruit sRNAome, transcriptome and gene regulation in response to CTV CDVd co infection
... represented by any mature plant-derived miRNA in miRBase. In addition to the predicted miRNAs, reads with sequences identical to 216 known plant miRNAs were also present in the data (Additional file 3: Table S8). ...
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In Silico Analysis of the Protein Structure of Tumor Suppressor Genes in Humans
... In silico analysis of the protein structures of Rb, p53, BRAC1 and BRAC2 genes revealed a high percentage of α-Helix content of the secondary protein structures of the genes; which provides maximal hydrogen ...
6
In silico ordinary differential equation/partial differential equation hemodialysis model estimates methadone removal during dialysis
... Hemodialysis experiments to test the model were performed in silico. On the one hand, we compared methadone’s mass transfer to that of a perfect reference standard. On the other hand, we compared methadone’s mass ...
13
Recent trends in drug-likeness prediction: A comprehensive review of In silico methods
... Methods to identify drug-like molecules are based on their ability to distinguish known drugs from non-drugs in the set of compounds by comparing with one or more of the following widely[r] ...
8
Analysis of the MAPK pathways, in silico and in vitro
... Introduction Materials and Methods Plasmids Plasmid purification for Cloning DNA Ligation and transform ation into competent cells PCR conditions for Chimera construction Chimera constru[r] ...
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