Infection: Smallpox
Antiviral Immunity following Smallpox Virus Infection: a Case-Control Study
... of infection, to estimate the total number of virus-specific CD8 ⫹ T cells ...following smallpox infec- tion or vaccination have indicated that T-cell memory is either short-lived or long-lived (33), and ...
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Rabbitpox Virus and Vaccinia Virus Infection of Rabbits as a Model for Human Smallpox
... of smallpox release and use as a bioweapon has encouraged the search for new vaccines and antiviral drugs, as well as development of new small-animal models in which their efficacy can be ...intradermal ...
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Expansion, Reexpansion, and Recall-Like Expansion of Vγ2Vδ2 T Cells in Smallpox Vaccination and Monkeypox Virus Infection
... V ␥ 2V ␦ 2 T cells in vaccinia virus-vaccinated macaques un- derwent expansion with HMBPP-induced IFN- ␥ -producing ef- fector function after immunization and mounted simple reex- pansion in association with sterile ...
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Modelling and Bayesian analysis of the Abakaliki smallpox data
... of infection for each individual, carry out various forms of model assessment to see how well the model fits the data, and explore par- ticular aspects of the model via ...
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Increasing the Immunogenicity of Vaccinia Virus Vectors by Insertion of Cowpox Virus A-Type Inclusions.
... immunomodulators, host range genes, and envelope proteins [24, 58, 142, 143]. We hypothesized that an immunization with either En-‐ATIs or rVV-‐ATIs would result in an immune response to those rVVs that is different ...
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Safety of Attenuated Smallpox Vaccine LC16m8 in Immunodeficient Mice
... B5R gene product (B5 protein), it has a strong protective ability against infection by virulent viruses in various immunodefi- cient mouse models (18–20). In this regard, we previously studied (18) the effect of ...
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Modelling and Bayesian analysis of the Abakaliki smallpox data
... variance, centered on the current parameter value. Proposed values outside the possible set for each parameter are immediately rejected (for example, all the infection rates must be positive, 0 ≤ v ≤ 1, etc.) Note ...
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Real Time PCR Assay To Detect Smallpox Virus
... against smallpox was discontinued in the United States and elsewhere nearly two decades ago, after the disease was declared eradicated in ...to smallpox virus infection. The fact that smallpox ...
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Preface: On the Eradication of Smallpox and the Beginning of a Public Health Career
... When the program began, in 1967, 43 countries were reporting cases of smallpox. More than 10 million cases and two million deaths were estimated to have occurred that year. The jet injector guns quickly came into ...
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Pox Britannica: Smallpox Inoculation in Britain, 1721-1830
... ith smallpox. Hospitals w ere reluctant to take smallpox patients for fear of the spread of infection; the one specialist hospital which did provide inoculation and isolated its patients could deal ...
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Detection of Smallpox Virus DNA by LightCycler PCR
... of smallpox virus, in addition to the infectivities of HSV and VZV, are readily destroyed by autoclaving of the ...acquired smallpox virus infection but does not affect the viral DNA that is the ...
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Following in the footsteps of smallpox: can we achieve the global eradication of measles?
... measles infection can be made on clini- cal grounds by experienced ...with smallpox has shown that as the incidence of disease decreases it becomes increasingly important to investigate every suspected case ...
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Countermeasures and vaccination against terrorism using smallpox: pre-event and post-event smallpox vaccination and its contraindications
... the smallpox vaccine was established through post-exposure prophylaxis and outbreak contain- ...preventing smallpox when administered within 4 days of exposure ...the smallpox vaccine can be admin- ...
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A simulation analysis to characterize the dynamics of vaccinating behaviour on contact networks
... influence infection dynam- ...on infection dynamics: individuals' decision to vaccinate or not likely depends on their per- ceptions of risk from the vaccine and the ...However, smallpox is the first ...
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Smallpox Vaccine
... 2. In a universal immunization campaign, the num- ber of adverse events would be expected to be higher than in the past because of the number of persons with contraindications, some of which might be undiagnosed or ...
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“Remarkable solutions to impossible problems”: lessons for malaria from the eradication of smallpox
... The World Health Organization (WHO) has called for the eradication of malaria since 1955 [1], when the Global Malaria Eradication Programme urged countries to seek to interrupt transmission through an effort involving ...
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Reassessing the foundations : Worldwide smallpox eradication, 1957-67
... That Smallpox and its Eradication does not present us with value-free sets of information on which there was wide-ranging agreement is proven by the wider body of work penned by its ...national smallpox ...
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Mucosal Vaccination against Enteric Pathogens in the Developing World
... areas. Infection often occurs in immunocompromised individuals ...2010). Infection is transmitted through the oral-fecal route from ingestion of oocysts in fecal-contaminated food or ...
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A Critical Analysis of the Scientific and Commercial Rationales for the De Novo Synthesis of Horsepox Virus
... new smallpox vaccine based on a novel viral ...second-generation smallpox vaccines were associated with a significant rate of adverse side effects, the third-generation smallpox vaccines that are ...
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