initiation of DNA replication
Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replication.
... In the presence of RF-A, a eucaryotic single-stranded DNA-binding protein required for origin-specific unwinding and the initiation of DNA replication 23, 81, and a topoisomerase which r[r] ...
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Control of initiation of DNA replication in Bacillus subtilis and Escherichia coli
... the initiation of DNA replication from oriC ...the DNA-bound polymerase β-clamp, DnaN ...of initiation is coupled to elongation in DNA replication, as ATP hydrolysis ...
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A study of the in vitro initiation of adenovirus DNA replication
... in replication by comparison (Hay, ...the replication origins of Ad2 and Ad4 showed that whilst the 1-18 core domain of the origin is identical in both serotypes, Ad4 possesses an A/T rich domain in place ...
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The role of CDK in the initiation step of DNA replication in eukaryotes
... of DNA replication, suggesting that phosphorylations of Thr600 and Ser622 are essential for cell growth and DNA replication and aspartic acid and glutamic acid residues do not mimic a ...
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Architectures of archaeal GINS complexes, essential DNA replication initiation factors
... template DNA unwinding reaction, and thus this complex is considered to be the functional replica- tive helicase ...both initiation and elonga- tion in DNA replication ...the ...
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DNA Replication-Initiation Proteins in Eukaryotic Cells
... the DNA replication initiation control mechanisms, several key questions remain ...of DNA replication licensing have been proposed, which although similar in principle, have fundamental ...
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The Stringent Response Inhibits DNA Replication Initiation in E coli by Modulating Supercoiling of oriC
... replication initiation control by ppGpp, we examined the role of topoisomerase I (topo I [encoded by ...negative DNA superhelicity ...in replication initiation ...of DNA ...
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Emerging players in the initiation of eukaryotic DNA replication
... HOX proteins control cell fate determination and pat- terning specification processes during development. They function as transcription factors that bind to DNA via their homeodomain [53-57]. Through a yeast two- ...
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DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression
... generations. DNA replication initiates from thousands of DNA elements within the genome called origins of ...of replication direct the assem- bly of a large group of proteins and protein ...
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Influence of retinoblastoma related gene silencing on the initiation of DNA replication by African cassava mosaic virus Rep in cells of mature leaves in Nicotiana benthamiana plants
... “ceased” replication machinery through its interaction with ...of DNA polymerase, could not restore the deficiency of DNA replication (Figure ...Consequently, DNA synthesis func- ...
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The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin melting.
... The failure of the zinc finger mutant T antigens to form hexamers in response to ATP may account for defects in subsequent steps in the initiation of DNA replication; we propose that hex[r] ...
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A genetic screen for replication initiation defective (rid) mutants in Schizosaccharomyces pombe
... bit initiation of DNA ...in DNA replication initiation that should be helpful in identifying new genes required for initiation, as well as hypomorphic alleles of known ...
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Initiation of simian virus 40 DNA replication in vitro.
... Since SV40 DNA replication absolutely depends on SV40 T antigen, anti-T serum from a tumor-bearing hamster was added to the reaction mixture containing both HeLa nuclear extract and CosI[r] ...
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Evidence That the pre-mRNA Splicing Factor Clf1p Plays a Role in DNA Replication in Saccharomyces cerevisiae
... 2C DNA content, and a short, intact mitotic ...the DNA replication initiation protein Orc2p in two-hybrid and co-immunoprecipitation assays, that Clf1p preferentially associates with origins ...
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The HIV Integrase Inhibitor Raltegravir Inhibits Felid Alphaherpesvirus 1 Replication by Targeting both DNA Replication and Late Gene Expression
... the initiation of DNA replication, which requires ...viral replication, it is not possible to create viable mutant viruses deficient in the complete ...inhibits DNA replication ...
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Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives
... nascent DNA pro- duced early during infection originated from specific regions within the 169 kb phage genome ...viral DNA, localizing origins to particular regions of the ...the DNA sequence ...
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Characterisation of Xenopus Origin Recognition Complex
... to replication elements that direct initiation in the chorion gene cluster (Figure 1/6, Austin et a l , ...the DNA fragment from the chorion gene cluster to confer initiation competence to ...
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Multiple and Specific Initiation of T4 DNA Replication
... 2A rules out a structure containing a single replicated region, as well as a structure containing multiple, closely clustered, replicative areas, or a structure containing one large repl[r] ...
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Multiple Initiation of Bacteriophage T4 DNA Replication: Delaying Effect of Bromodeoxyuridine
... This is also suggested by the similar phage DNA synthesis on a light template as there is on a heavy template in mixedly infected cells early after infection, suggesting that heavy DNA i[r] ...
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Initiation of adenovirus DNA replication.
... Subsequent analysis of the strand distribution of pulse-label in the double-stranded, terminal restriction enzyme fragments from these molecules in the course of either early displacemen[r] ...
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