inner hair cells
FM1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea
... the inner hair cells (IHCs) of the ...neuroepithelial cells that have mechanosensory stere- ocilia at their apical surface and, as determined for the cat, ⬃20 synaptic release sites around ...
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Development and Function of the Voltage-Gated Sodium Current in Immature Mammalian Cochlear Inner Hair Cells
... Inner hair cells (IHCs) of the mature mammalian cochlea relay sound information transduced by mechano-sensitive channels [1] to the central nervous system with high temporal precision [2] via the ...
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Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea.
... regulates inner ear development from the formation of the embryonic otic ...in hair cell maturation remains ...outer hair cells (OHCs) differentiate normally but their numbers are ...
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Connexin-Mediated Signaling in Nonsensory Cells Is Crucial for the Development of Sensory Inner Hair Cells in the Mouse Cochlea
... nonsensory cells has been proposed to be the main trigger for action potential activity in immature sensory inner hair cells (IHCs), which is crucial for the refinement of the developing ...
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Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding
... basal inner hair cells (IHCs) to sound-like stimulation of different ...basal cells (F, n = ...basal cells show a pronounced graded (DC) response to the stimulus ...
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Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation
... sensory hair cells are open, resulting in a sustained depolarizing ...mature inner hair cells ...into cells showing electrical and morphological features characteristic of ...
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Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells
... During the first (but not the second) postnatal week the V m of immature IHCs (Fig. 4a) is positive to the potential at which the Ca 2+ current becomes activated (−65 mV 14 , 31 ), so at this stage there is no ...
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Association of intracellular and synaptic organization in cochlear inner hair cells revealed by 3D electron microscopy
... The ways in which cell architecture is modelled to meet cell function is a poorly understood facet of cell biology. To address this question, we have studied the cytoarchitecture of a cell with highly specialised ...
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Auditory Sparse Representation for Robust Speaker Recognition Based on Tensor Structure
... As described in Section 3.1, the cochlear power feature can be considered as neuron response in the inner hair cells, and hair cells have receptive fields which refer to a coding of ...
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Original Article Spatiotemporal expression of Bmi1 in the developing mouse cochlea
... auditory hair cells (outer hair cells and inner hair cells) and at least four types of supporting cells (Hensen’s cells, pillar cells, inner ...
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An Analogue VLSI Implementation of the Meddis Inner Hair Cell Model
... Inner hair cells (IHCs) are mechanical to neural transducers located within the cochlea and play an important role in bio- logical sound processing. Sound captured by the eardrum is translated into ...
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FM1-43 dye behaves as a permeant blocker of the hair-cell mechanotransducer channel
... pretreating cells with calcium chelators, a condition known to break tip links and prevent channel ...outer hair cells by Meyer et ...chick hair cells after BAPTA treatment (Zhao et ...
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The LINC complex is essential for hearing
... both inner hair cells (IHCs) and outer hair cells (OHCs) as well as supporting cells and neurons, each with their own unique structural ...
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Dexamethasone uptake in the murine organ of Corti with transtympanic versus systemic administration
... After systemic and transtympanic injection, a decreasing basal-apical gradient of steroid uptake was present within hair cells which has not been previously characterized (Figure 2A-D). Salt et al. have ...
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In vivo and in vitro biophysical properties of hair cells from the lateral line and inner ear of developing and adult zebrafish.
... all hair cells positioned within each of the three neuromasts investigated (L2–L4: ...of hair cells within each neuromast showed similar levels of variability, which is also supported by the ...
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Cross regulation of Ngn1 and Math1 coordinates the production of neurons and sensory hair cells during inner ear development
... and hair cell generation are each dependent on an Atonal-related bHLH transcription ...epithelial cells to a neural fate, as Ngn1 –/– embryos lack an VIIIth cranial ganglion and fail to express neural fate ...
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Proprioception In Insects
... Two, the inner and the outer coxal hair plates, are situated in the membrane between the coxa and the pleuron, and one, the trochanteral hair plate, near the ventral coxo-trochanteral co[r] ...
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Adenovirus Vectors Target Several Cell Subtypes of Mammalian Inner Ear In Vivo
... of hair cell regeneration: (1) direct transdifferentiation of surrounding cells especially supporting cells to change cell fate to become hair cells and (2) induction of cell cycle ...
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Nociceptin and the OP4 receptor in the auditory system
... Adult animals were killed by cervical dislocation. Immediately following sacrifice, the animals were decapitated and heads placed in cold PBS, kept in an icebox. The dissection was carried out on ice, under a Wild ...
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Auditory Function in the Tc1 Mouse Model of Down Syndrome Suggests a Limited Region of Human Chromosome 21 Involved in Otitis Media
... transferred into a microscope chamber containing extracellular solution, and immobilized with a nylon mesh fixed to a stainless steel ring. The chamber (volume 2 ml) was perfused at a flow rate of about 10 ml?h 21 from a ...
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