Insulin promoter
A variant insulin promoter in non insulin dependent diabetes mellitus
... the insulin gene occur in a subset of patients with non-insulin-dependent diabetes mellitus (NIDDM), the promoter region was studied by polymerase chain reaction (PCR) amplification directly from ...
8
Missense mutations in the insulin promoter factor 1 gene predispose to type 2 diabetes
... factor insulin promoter factor-1 (IPF-1) plays a central role in both the development of the pancreas and the regulation of insulin gene expres- sion in the mature pancreatic β ...human ...
8
Defective mutations in the insulin promoter factor 1 (IPF 1) gene in late onset type 2 diabetes mellitus
... between insulin production and ...the insulin promoter factor-1 (IPF-1), a pancreatic β-cell specific transcription factor, causes pancreatic agenesis and ...basal insulin promoter ...
9
Insulin promoter factor 1 gene mutation linked to early onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein
... factor insulin promoter factor-1 (IPF-1) is required for development of the pancreas and also mediates glucose-responsive stimulation of insulin gene ...
11
Transgenic Mice Expressing Shb Adaptor Protein under the Control of Rat Insulin Promoter Exhibit Altered Viability of Pancreatic Islet Cells
... tive area of whole pancreas, insulin secretion of isolated islets and islet cell apoptosis, glucose tolerance tests, and.. in vivo sensitivity to multiple injections of the 13-cell.[r] ...
12
Grzech, Marjeta (2010): Analysis of a new transgenic mouse model with ß-cell-specific overexpression of human betacellulin. Dissertation, LMU München: Tierärztliche Fakultät
... rat insulin 2 gene (Ins2) promoter, widely used to achieve transgene expression in pancreatic β -cells of mice, also directs expression to extrapancreatic tissues and performs poorly in isolated pancreatic ...
100
Pancreas enriched miRNA refines endocrine cell differentiation
... MafB, insulin and ...higher insulin-positive and glucagon-positive cell numbers in miR-7 KD, are consistent with miR-7 function in the differentiation of endocrine cell types, upstream of ...
11
Chronic exposure of betaTC 6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator
... of insulin secretion and biosynthesis, stimulates insulin gene transcription, and sta- bilizes insulin mRNA levels (reviewed in reference ...decrease insulin gene transcription in HIT-T15 ...
7
Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein
... To determine whether decreased insulin promoter activity might be associated with altered activity of transcription factors that interact with insulin gene regulatory sequences, nuclear [r] ...
7
DNA immunization to prevent autoimmune diabetes
... rat insulin promoter (RIP) lymphocytic choriomeningitis virus nucleoprotein (LCMV-NP) mouse model for virally induced insulin-dependent diabetes mellitus (IDDM), LCMV-NP is expressed as a “self ” ...
7
A novel viral RNA species in Sindbis virus-infected cells.
... subgenomic promoter, four nucleotides before the initiation site of the subgenomic ...full promoter and is at much lower abundance with the minimal ...
10
Assessment of a Case of Immediate Type Allergy against Human Insulin in a Type 2 Diabetic Patient and Allergic Reactions to Human Insulin in Japan
... evaluate insulin allergy, intradermal skin tests were performed with several insulin agents for clinical use and ...human insulin resulted in local, immediate skin reactions such as itchy erythema ...
5
PTX3 gene activation in EGF-induced head and neck cancer cell metastasis
... Overexpression of the epidermal growth factor (EGF) receptor (EGFR) is associated with enhanced invasion and metastasis in head and neck squamous cell carcinoma (HNSCC). Long Pentraxin PTX3 is involved in immune escape ...
17
Needle-free insulin drug delivery
... transplants to become a widespread clinical reality, diabetes reversal must be achieved with a single donor to reduce risks and cost and increase the availability of transplantation. Researchers in their study find out ...
6
Conformational flexibility of the pharmacologically important insulin analogues
... of insulin, a number of advances have been made to allow patients to mimic the normal pattern of insulin release more accurately and conven- ...However, insulin therapy needs to improve still further ...
6
Prediction of plant promoters based on hexamers and random triplet pair analysis
... Using a different type of negative dataset in conjunc- tion with the same positive dataset (the previously used 305 promoters), we extracted features, trained our method, and performed a 5-fold cross validation test in ...
10
The myoglobin gene of the Antarctic icefish, Chaenocephalus aceratus, contains a duplicated TATAAAA sequence that interferes with transcription
... Results from our in vivo transient expression assays with oxidative skeletal muscle of C. aceratus (Fig. 3) permit two additional conclusions. First, the minimal promoter required for C. rastrospinosus Mb ...
9
Tumour-specific arginine vasopressin promoter activation in small-cell lung cancer
... intrinsic promoter activity in the promoterless construct pVEN, where the ratio of CAT to β Gal expression (n = 3) was zero in both the Lu-165 and NCI-H460 cell ...tk promoter in all cell lines tested ...
10
Combination of Genetics and Nanotechnology for Down Syndrome Modification: A Potential Hypothesis and Review of the Literature
... hancer for brain cells special promoter (i.e. MECP2 promoter), MECP2 expression promoter, XIST gene as a main epigenetic modifier factor for inducing inactivation on relevant chromosome[r] ...
8
Transcriptional regulation of human JC polyomavirus promoters by cellular proteins YB-1 and Pur alpha in glial cells.
... early promoter, however, was less than that of the late pro- moter in the transfected cells ...early promoter, but not the late promoter, and the capacity of YB-1 and T antigen to enhance JCV late ...
6