Insulin Receptor Substrate
Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... Pim substrate(s) that could help define the pathway regulated by these enzymes and potentially serve as a biomarker of Pim ...the insulin receptor substrate 1 and 2 (IRS1/2) as potential Pim ...
14
The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila
... of insulin signaling in D. melanogaster by mutation of the insulin receptor substrate Chico does not affect the survival of the mutant flies upon bacterial ...
11
Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI 3-kinase), ...
9
Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... the insulin receptor sub- strate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) gene polymorphisms in patients with MetS and 2) to examine the relationships be- tween gene ...
7
<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Insulin receptor substrate (IRS) docking proteins are the key downstream signaling molecules in the insulin receptor (IR) signaling ...that insulin can act as a growth factor in ...
7
Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... that insulin receptor substrate 2 (Irs2) KO mice develop diabetes associated with hepatic insulin resistance, lack of compensatory β cell hyperplasia, and leptin ...normal insulin ...
12
Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an oral glucose ...
7
Upregulation of insulin receptor substrate 2 in pancreatic β cells prevents diabetes
... RNA isolation, cRNA preparation, and array hybridiza- tion. WT mice aged 4–6 weeks displaying normal fast- ing and random-fed insulin and blood glucose levels were starved overnight, anesthetized in the morning by ...
13
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
... AMPA receptor-EPSC amplitude was measured as the average peak of 10 consecutive EPSC traces, evoked at a holding potential of 270 ...NMDA receptor- mediated EPSC amplitude was measured as the average of 10 ...
13
Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
... in insulin binding and a parallel increase in insulin-stimulated receptor phosphorylation in muscle of fasting and streptozotocin-induced (STZ) diabetic ...overall receptor phosphorylation in ...
12
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... and insulin-stimulated tyro- sine phosphorylation of ...reduced insulin-stimulated tyrosine phosphorylation of IRS-1 (Figure ...compromised insulin signalling, which can be overcome by inhibition of ...
14
erbB3 recruitment of insulin receptor substrate 1 modulates insulin like growth factor receptor signalling in oestrogen receptor positive breast cancer cell lines
... As mentioned previously, another interesting phenom- enon noted in these studies is the finding that whilst HRG b 1 treatment enhanced erbB3-IRS-1 interactions, it also promoted a decrease in the association between IRS- ...
17
Insulin receptor substrate 1 in osteoblast is indispensable for maintaining bone turnover
... Estrogen receptor, another nuclear receptor that is essential to reg- ulate osteoblast function, is known to be activated through phosphorylation by MAP kinase ...
10
The role of insulin receptor substrate 2 in hypothalamic and β cell function
... in potassium PBS (KPBS), pH 7.4, blocked with 2% serum in KPBS/0.4% Triton X-100 (KPBS-T) for 1 hour at room temperature, and then incu- bated with primary antibodies in KPBS-T for 48 hours at 4°C. Slices were incubated ...
12
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
... and insulin levels ...and insulin levels are higher than adult levels, and aas are abun- dant, which parallels low rates of autophagy ...and insulin levels fall (6, 7), in concert with a rapid ...
16
Expression and function of the insulin receptor substrate proteins in cancer
... Amplified in breast cancer 1 (AIB1), also known as steroid receptor coactivator-3 (SRC-3), regulates both IRS-1 and IRS-2 expression [114,115]. AIB1 is an oncogene that is often overexpressed in human tumors and ...
15
L Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate 1
... Therefore, insulin resistance in the liver is characterized by deficient responses to insulin, such as enhanced gluconeogenesis [3], which ultimately cause or worsen ...for insulin re- sistance is a ...
9
Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer
... a role for the ErbB2-IRS cooperation in antiestrogen re- sistance, but suggests that ErbB2 amplified human breast cancers may have sufficient ErbB2-induced regulation and signaling. It is also possible that the ...
7
Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... IR: insulin resistance; IRS: insulin receptor substrate; JAK‑STAT : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: ...
15
Download Download PDF
... catenin, insulin (IN)/insulin-like growth factor 1 (IGF-1)/ insulin receptor substrate 1 (IRS1)/phosphatidylinositol-3-ki- nase (PI3K)/protein kinase B (Akt), and IN/IGF-1/IRS1/ ...
8