insulin receptor substrate 2
Original Article Insulin receptor substrate-2 (IRS-2) rs1805097 G>A polymorphism is associated with colorectal cancer susceptibility: a meta-analysis involving 11,234 subjects
... the insulin receptor substrate-2 (IRS-2) rs1805097 G>A polymorphism in colorectal cancer (CRC) susceptibility, we conducted a comprehensive meta-analysis, which included 5,220 CRC ...
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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... that insulin receptor substrate 2 (Irs2) KO mice develop diabetes associated with hepatic insulin resistance, lack of compensatory β cell hyperplasia, and leptin ...normal ...
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Gly1057Asp polymorphism of insulin receptor substrate-2 is associated with coronary artery disease in the Taiwanese population
... and insulin resistance, which was evaluated using the HOMA-IR ...and insulin resist- ance, we defined a BMI value greater than 25 kg/m 2 as obesity according to the Asia-Pacific perspective redefin- ...
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Dysregulation of insulin receptor substrate 2 in β cells and brain causes obesity and diabetes
... Type 2 diabetes affects ...(1, 2). Most disease models point to obesity as an important cause of type 2 diabetes, because of its association with skeletal muscle insulin resistance and ...
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Upregulation of insulin receptor substrate 2 in pancreatic β cells prevents diabetes
... Plasma insulin levels were determined using a competitive ELISA (Crystal Chem ...Glucose-stimulated insulin release was meas- ured in fasted mice injected intraperitoneally with D - glucose (3 ...
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
... NMDA receptor-mediated short-term (STP) and long-term potentiation (LTP) in Schaffer collateral-commissural ...Ca 2+ are necessary to evoke persistent changes in synaptic efficacy, such as LTP ...NMDA ...
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The role of insulin receptor substrate 2 in hypothalamic and β cell function
... with 2% serum in ...diaminobenzidine substrate kit for peroxidase (Vector ...taining 2 ng/μl digoxigenin-labeled (DIG-labeled) probe was applied and sections covered with glass coverslips and ...
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Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... type 2 diabetic pa- tients and ...with insulin resistance, salt sensitivity and non-dipper hypertension ...the insulin receptor substrate-1 (IRS-1) and insulin receptor ...
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Hippo mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer
... (PTEN) or the protein kinase Hippo signaling pathway induces liver cancer via activation of AKT or the transcriptional regulators YAP/TAZ, respectively; however, the potential for crosstalk between the PTEN/AKT and ...
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Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... immunoprecipitates was decreased by 79.5 +/- 11.2% (P < 0.02). In muscle, the changes were less dramatic, and often in opposite direction of those observed in liver. Thus, there was no significant change in ...
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Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus
... P2Y12 receptor blockers such as prasugrel and ticagrelor were found that they were superiors in terms of pharmaco- dynamics and pharmacokinetic effects than clopidogrel ...
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The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila
... Infected and PBS-injected chico mutant and yw back- ground control flies were collected at 3, 24 and 48 h post infection and stored in a -80 °C freezer. Four flies were used for each experimental condition. Total RNA was ...
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Insulin receptor substrate 1 in osteoblast is indispensable for maintaining bone turnover
... Insulin receptor substrates (IRS-1 and -2) are essential for intracellular signaling by insulin and IGF-I, anabolic regulators of bone ...with insulin or IGF-I failed to induce tyrosine ...
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Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
... glucose, insulin, and ...Figure 2). At 3 hours after Caesarean section, insulin and aa concentrations fell more than 75%, and glucose concentrations by 30%, in mice of all genotypes; these increased ...
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PubMedCentral-PMC4798554.pdf
... I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor ...the insulin receptor substrate (IRS) adaptor ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... This study included 583 patients with MDD and 564 healthy controls. Demographic characteristics of our parti- cipants are presented in Table S1. As shown in Table S1, female participants were about twice as likely as ...
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Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... lane 2) or omit- ted (Figure 1C lane 3), no radioactive proteins were observed, indicating that the interaction between the two proteins is specific and not due to non-specific interac- tions with immunoglobulins ...
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... vivo substrate for Pim protein kinases, MEF cells derived from wild type (WT) and triple knockout of Pim1, Pim2 and Pim3 (TKO) FVB mice were ...Pim1, 2 and 3 by siRNAs in non-small cell lung carcinoma cell ...
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Expression and function of the insulin receptor substrate proteins in cancer
... The IRS proteins have been implicated in contributing to all stages of cancer, from initiating events to metastatic progression. However, there is still much to be learned about the mechanisms by which each of the IRS ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an oral glucose ...
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