Insulin receptor substrate (IRS)
Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... the insulin receptor sub- strate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) gene polymorphisms in patients with MetS and 2) to examine the relationships be- tween ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Insulin receptor substrate (IRS) docking proteins are the key downstream signaling molecules in the insulin receptor (IR) signaling ...The IRS is spread widely in the ...
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Original Article Insulin receptor substrate-2 (IRS-2) rs1805097 G>A polymorphism is associated with colorectal cancer susceptibility: a meta-analysis involving 11,234 subjects
... the insulin receptor substrate-2 (IRS-2) rs1805097 G>A polymorphism in colorectal cancer (CRC) susceptibility, we conducted a comprehensive meta-analysis, which included 5,220 CRC cases and ...
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The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects
... identify insulin receptor substrate 1 (IRS-1) gene polymorphism Gly972Arg as the risk factor for ischemic stroke among Indonesian ...lyze IRS-1 gene Gly972Arg ...
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Original Article MicroRNA-126 acts as a tumor suppressor in glioma cells by targeting insulin receptor substrate 1 (IRS-1)
... Furthermore, insulin receptor substrate 1 (IRS-1) were identified as a target of miR-126, and showed that it was negatively regulated by miR-126 in glioma ...targeting IRS-1 expression ...
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Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an oral ...
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Erythroid Cells Rendered Erythropoietin Independent by Infection with Friend Spleen Focus-Forming Virus Show Constitutive Activation of Phosphatidylinositol 3-Kinase and Akt Kinase: Involvement of Insulin Receptor Substrate-Related Adapter Proteins
... Epo receptor tyrosine phosphorylation, is required for the proliferation of these cells in the absence of ...the insulin receptor substrate (IRS)-related adapter molecules IRS-2, ...
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... Pim substrate(s) that could help define the pathway regulated by these enzymes and potentially serve as a biomarker of Pim ...the insulin receptor substrate 1 and 2 (IRS1/2) as potential Pim ...
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Expression and function of the insulin receptor substrate proteins in cancer
... The IRS proteins have been implicated in contributing to all stages of cancer, from initiating events to metastatic ...the IRS proteins differentially contribute to tumor cell function and the manner in ...
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Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... that insulin-stimulated tyrosine phosphorylation of IRS-1 was not affected (data not shown), indicating that specific reductions in HDAC2 after RNAi treatment were the main cause of enhanced insulin ...
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Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus
... the IRS-1 gene have a hyperreactive platelet phenotype and increased risk of major adverse cardiac events ...the IRS-1 gene which doesn’t affect amino acid coding and protein ...the IRS-1 gene, and ...
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Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
... known. Insulin signaling in the heart is transduced via insulin and IGF-1 receptors ...disrupted insulin and IGF-1R signaling by generating mice with combined cardio- myocyte-specific deletion of ...
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Pioglitazone administration alters ovarian gene expression in aging obese lethal yellow mice
... Moreover, insulin and insulin-like growth factor cellular signaling were differen- tially altered in ovarian cells from women with PCOS, but after TZD treatment cell signaling was similar to cells from ...
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Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... IR: insulin resistance; IRS: insulin receptor substrate; JAK‑STAT : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: ...
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Glucocorticoid regulation of insulin receptor and substrate IRS 1 tyrosine phosphorylation in rat skeletal muscle in vivo
... glucocorticoid-induced insulin resistance might originate from abnormalities in insulin receptor signaling, we investigated the effects of glucocorticoids on in vivo tyrosine phosphorylation of the ...
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PubMedCentral-PMC4798554.pdf
... I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor ...the insulin receptor substrate (IRS) ...
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MicroRNA-1225-5p behaves as a tumor suppressor in human glioblastoma via targeting of IRS1
... the insulin receptor substrate 1 (IRS1) was a direct functional target of miR-1225-5p in glioblastoma, and the mRNA and protein levels of IRS1 in six human glioblastoma cell lines (A172, SW1783, U87, ...
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Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin receptor signaling by high glucose lev- els and by TNF- a was recently observed in different cell sys- ...–induced insulin receptor inhibition and to compare the consequences of ...
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Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels A potential role for serine phosphorylation in insulin/angiotensin II crosstalk
... terestingly, IRS-1 and PI 3–kinase are also intracellular targets for receptors other than the insulin receptor, such as growth hormone and interferon g (64), suggesting that these inhibi- tory ...
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