insulin receptor substrate(s)
Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... Pim substrate(s) that could help define the pathway regulated by these enzymes and potentially serve as a biomarker of Pim ...the insulin receptor substrate 1 and 2 (IRS1/2) as ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Insulin receptor substrate (IRS) docking proteins are the key downstream signaling molecules in the insulin receptor (IR) signaling ...that insulin can act as a growth factor in ...
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The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila
... Here we have tested the immune response of D. melano- gaster flies mutant for the insulin receptor substrate Chico against pathogenic and non-pathogenic bacteria. We have chosen to use a professional ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an oral glucose ...
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Insulin receptor substrate 2 plays a crucial role in β cells and the hypothalamus
... that insulin receptor substrate 2 (Irs2) KO mice develop diabetes associated with hepatic insulin resistance, lack of compensatory β cell hyperplasia, and leptin ...normal insulin ...
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Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... with insulin resistance, salt sensitivity and non-dipper hypertension ...the insulin receptor substrate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) gene polymor- ...
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Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1 (IRS-1), which in turn associates with phosphatidylinositol 3-kinase (PI 3-kinase), ...
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The role of insulin receptor substrate 2 in hypothalamic and β cell function
... Through global gene deletion, we and others have previously implicated Irs2 in the regulation of β cell function and peripheral glucose metabolism and the central regulation of energy homeostasis (10, 11, 19, 22). These ...
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erbB3 recruitment of insulin receptor substrate 1 modulates insulin like growth factor receptor signalling in oestrogen receptor positive breast cancer cell lines
... elements MAPK and Akt were activated following HRGb1 treatment, with this ligand having a more potent effect on phosphorylation levels in MCF-7 and T47D cells that on BT-474 cells. Interestingly, HRGb1 treatment also ...
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Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity
... AMPA receptor-EPSC amplitude was measured as the average peak of 10 consecutive EPSC traces, evoked at a holding potential of 270 ...NMDA receptor- mediated EPSC amplitude was measured as the average of 10 ...
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Upregulation of insulin receptor substrate 2 in pancreatic β cells prevents diabetes
... In our experiments, glucagen-like peptide 1, exendin- 4 or dibutyl-cAMP strongly upregulated Irs2 protein in Min6 β cells, and similar results were observed with iso- lated human islets (data not shown). A mechanism for ...
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Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
... in insulin binding and a parallel increase in insulin-stimulated receptor phosphorylation in muscle of fasting and streptozotocin-induced (STZ) diabetic ...overall receptor phosphorylation in ...
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Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... and insulin-stimulated tyro- sine phosphorylation of ...reduced insulin-stimulated tyrosine phosphorylation of IRS-1 (Figure ...compromised insulin signalling, which can be overcome by inhibition of ...
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Insulin receptor substrate 1 in osteoblast is indispensable for maintaining bone turnover
... of insulin on bone formation may be related to its abil- ity to stimulate cell proliferation (1, ...pancreatic insulin production lose bone rapidly, and this loss is off- set by insulin replacement ...
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Expression and function of the insulin receptor substrate proteins in cancer
... [19-21]. The second conserved region is the phosphotyro- sine binding (PTB) domain, which interacts with NPXY motifs in activated receptors [22,23]. An additional motif that contributes to receptor recruitment, ...
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L Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate 1
... Therefore, insulin resistance in the liver is characterized by deficient responses to insulin, such as enhanced gluconeogenesis [3], which ultimately cause or worsen ...for insulin re- sistance is a ...
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Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
... and insulin levels ...and insulin levels are higher than adult levels, and aas are abun- dant, which parallels low rates of autophagy ...and insulin levels fall (6, 7), in concert with a rapid ...
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Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer
... a role for the ErbB2-IRS cooperation in antiestrogen re- sistance, but suggests that ErbB2 amplified human breast cancers may have sufficient ErbB2-induced regulation and signaling. It is also possible that the ...
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Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation
... IR: insulin resistance; IRS: insulin receptor substrate; JAK‑STAT : Janus kinase‑Signal Transducer and Activator of Transcription; JNK: c‑Jun N‑terminal kinase; K: clot kinetics; LDL: ...
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Acute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction
... unknown. Insulin signaling plays a key role in the regulation of glucose ...of insulin signaling pathways could be a potential contributor to acute hyperglycemia after ...and insulin levels were ...
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