insulin substrate receptor 1
Insulin receptor substrate gene polymorphisms are associated with metabolic syndrome but not with its components
... were 1) to investigate the insulin receptor sub- strate-1 (IRS-1) and insulin receptor substrate-2 (IRS-2) gene polymorphisms in patients with MetS and 2) to ...
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L Citrulline increases hepatic sensitivity to insulin by reducing the phosphorylation of serine 1101 in insulin receptor substrate 1
... the insulin resistance-improving effects of L-Cit in ...to insulin due to a mutated leptin receptor ...trigger insulin re- sistance in ...of insulin resistance and type-2 diabetes ...
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PubMedCentral-PMC4798554.pdf
... I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor ...the insulin receptor substrate (IRS) adaptor ...
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erbB3 recruitment of insulin receptor substrate 1 modulates insulin like growth factor receptor signalling in oestrogen receptor positive breast cancer cell lines
... of insulin receptor sub- strate (IRS) members, a family of structurally related adaptor molecules which have classically been identified as key signalling intermediates of the IR and IGF-IR ...kinase ...
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MicroRNA-1225-5p behaves as a tumor suppressor in human glioblastoma via targeting of IRS1
... the insulin receptor substrate 1 (IRS1) was a direct functional target of miR-1225-5p in glioblastoma, and the mRNA and protein levels of IRS1 in six human glioblastoma cell lines (A172, ...
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Expression and function of the insulin receptor substrate proteins in cancer
... The IRS proteins have been implicated in contributing to all stages of cancer, from initiating events to metastatic progression. However, there is still much to be learned about the mechanisms by which each of the IRS ...
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Acute Hepatic Insulin Resistance Contributes to Hyperglycemia in Rats Following Myocardial Infarction
... unknown. Insulin signaling plays a key role in the regulation of glucose ...of insulin signaling pathways could be a potential contributor to acute hyperglycemia after ...and insulin levels were ...
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Modulation of insulin receptor, insulin receptor substrate 1, and phosphatidylinositol 3 kinase in liver and muscle of dexamethasone treated rats
... immunoprecipitates was decreased by 79.5 +/- 11.2% (P < 0.02). In muscle, the changes were less dramatic, and often in opposite direction of those observed in liver. Thus, there was no significant change in ...
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Understanding the mechanisms of aromatase inhibitor resistance
... (insulin receptor substrate 1), SERPINA3, TFF1 and TFF3 (trefoil factors 1 and 3) and proliferation markers (CDC2, Cyclin B1, CKS2, thymidylate synthase (TYMS), proliferating cell ...
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The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects
... Subjects underwent the following procedures: general physical examination; complete neurological examina- tion; non-contrast brain computed tomography (CT) scan or non-contrast magnetic resonance imaging (MRI) to confirm ...
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Insulin receptor substrate 1 in osteoblast is indispensable for maintaining bone turnover
... ation stages were determined by semiquantitative RT-PCR within an exponential phase of the amplification. Total RNA was extracted from cultured osteoblasts from neonatal calvariae, osteoclasts formed in the coculture of ...
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A common amino acid polymorphism in insulin receptor substrate 1 causes impaired insulin signaling Evidence from transfection studies
... at insulin concentrations ranging from 0 to 1,000 nM and expressed as a percentage of maximal proliferation stimulated by ...endogenous insulin receptors did not proliferate upon exposure to insulin ...
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Insulin receptor phosphorylation, insulin receptor substrate 1 phosphorylation, and phosphatidylinositol 3 kinase activity are decreased in intact skeletal muscle strips from obese subjects
... 0.9). Insulin- stimulated 2-deoxyglucose uptake was 53% lower in muscle strips from obese ...M insulin for 2, 15, or 30 ...the insulin receptor and insulin receptor ...
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Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
... Tables 1 and 2). Transcriptional analysis in 1-day-old hearts showed preserved expression of genes involved in fatty acid oxida- tion (FAO), oxidative phosphorylation (OXPHOS), and their tran- scriptional ...
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Association between insulin receptor substrate-1 polymorphisms and high platelet reactivity with clopidogrel therapy in coronary artery disease patients with type 2 diabetes mellitus
... Genomic DNA samples were extracted from peripheral blood lymphocytes of patients using TIANamp Blood DNA kits (Tiangen Biotech CO., LTD. Beijing, China). DNA concentration and quality were assessed using absorbance ...
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Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... (Pim 1, 2, and 3) contribute to cellular transformation by regulating glucose metabolism, protein synthesis, and mitochondrial oxidative ...Pim substrate(s) that could help define the pathway regulated by ...
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<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Our results should be interpreted with caution because MDD is a heterogeneous disorder based on multiple factors including socioeconomic status, family support, biological and genetic aspects. 4,8 Our study had several ...
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Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
... in insulin signal transmission based on studies with insulin receptor ...of insulin receptor and IRS-1 in liver and muscle after insulin stimulation in vivo in two rat ...
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Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin receptor signaling by high glucose lev- els and by TNF- a was recently observed in different cell sys- ...–induced insulin receptor inhibition and to compare the consequences of ...
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Insulin receptor substrate 1 variants in non insulin dependent diabetes
... Insulin receptor substrate-1 (IRS-1) plays an important role in insulin-stimulated signaling ...in insulin secretion capacity (estimated by insulin responses in an ...
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