Integrin αIIbβ3
Lnk regulates integrin αIIbβ3 outside in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
... β3 integrin subunit, and reduced binding of Fyn to integrin ...of αIIbβ3-based outside-in signaling, which appears to be coordinated in platelets by Lnk, Fyn, and ...
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von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3
... of integrin αIIbβ3 in platelets from mice expressing a vWD-type 2B–associated vWF ...Further, αIIbβ3 activation and activation of the small GTPase Rap1 were impaired by ...
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Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
... in integrin αIIbβ3 inside-out and outside-in ...duce αIIbβ3 activation in CHO cells by interacting with the N 756 ITY 759 motif of the integrin β3 cytoplasmic ...regulates integrin ...
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Interactions between integrin αIIbβ3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans
... by PP1/PP2A and p38 MAPK signaling. Coimmunoprecipitation experi- ments showed that the elevated SERT activity did not arise from an allele-dependent effect on the formation/stability of SERT/integrin ...
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Structural Characterization of the Integrin Αiibβ3 Transmembrane and Cytosolic Domains
... The structure of the resting integrin αIIbβ3’s transmembrane and cytosolic domains was characterized by molecular modeling and NMR spectroscopy. First, software was developed to model transmembrane helix ...
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The antithrombotic potential of selective blockade of talin dependent integrin αIIbβ3 (platelet GPIIb–IIIa) activation
... 3 integrin cytoplasmic domain (tail) results in integrin a IIb b 3 (GPIIb–IIIa) ...for integrin activation in vivo and its biological significance by generating mice harboring point mutations in the ...
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Structure and function of the platelet integrin αIIbβ3
... The platelet integrin a IIb b 3 is required for platelet aggregation. Like other integrins, a IIb b 3 resides on cell surfaces in an equilibrium between inactive and active conformations. Recent experiments ...
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Iron regulated surface determinant B (IsdB) promotes Staphylococcus aureus adherence to and internalization by non phagocytic human cells
... platelet integrin αIIbβ3 we used a CHO-K1 cell line stably expressing human wild-type 171.. αIIbβ3 and the N305T mutant locked in the high affinity conformation by an N-172.[r] ...
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Different Stages of Platelet Adhesion to the Site of Vascular Injury
... The vWf/GPIb-V-IX interaction slows platelet velocity in the rapidly flowing blood allowing other receptors with slower binding kinetics to bind their specific ligands. Meanwhile, platelet activation contributed by ...
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PKCα regulates platelet granule secretion and thrombus formation in mice
... In summary, we have shown PKCα to play major roles in regulating platelet secretion of α-granules, biogenesis and secretion of dense granules, regulation of integrin αIIbβ3, and thrombus[r] ...
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HPA-1 polymorphism of αIIbβ3 modulates platelet adhesion onto immobilized fibrinogen in an in-vitro flow system
... integri αIIbβ3 is intimately involved in the occlusive thrombus formation at the site of endothelial ...of integrin αIIbβ3 on platelet adhesion onto immobilized fibrinogen using an in vitro system ...
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Anti D4GDI antibodies activate platelets in vitro: a possible link with thrombocytopenia in primary antiphospholipid syndrome
... Recent proteomic and transcriptomic studies indicate that D4GDI is highly expressed in platelets [6–8]. Con- sistently with the inhibitory role of D4GDI and with our previous observations in lymphocytes, when we incubate ...
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Role of Integrin-linked kinase in epidermal integrity and barrier function
... receptor integrin αMβ2, also termed CR3, proceeds through activation of RhoA (117, 126), whereas Fc γ -receptor- mediated phagocytosis involves activation of Cdc42 and Rac1 ...
235
Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed αvβ3 and αvβ5 integrins
... v integrin subunit is produced in excess, and its cell sur- face appearance is limited by the transcription level of the associated b subunits ...v integrin subunit was massively ...
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Radovanac, Korana (2012): Regulation of integrin-linked kinase (ILK) stability. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... ILK is a central scaffolding element of 1 and 3 integrin containing focal adhesions (Hannigan, Leung-Hagesteijn et al. 1996). Taken that ILK regulates many cellular functions such as cell spreading, migration and ...
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The PlA2 polymorphism of integrin β3 enhances outside in signaling and adhesive functions
... dependent manner than did Pl A1 cells. Disruption of the actin cytoskeleton by cytochalasin D abolished the increased binding of Pl A2 cells. Compared with Pl A1 cells, Pl A2 cells exhibited a greater extent of ...
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Popov, Tzvetan (2011): Characterization of human mesenchymal stem cells by the appearance of integrins and functional analysis of collagen I-binding integrins. Dissertation, LMU München: Medizinische Fakultät
... which integrin a1- and shRNA control hMSC passed was approximately 170 µm with mean speed of ...parallel integrin a2 and a11-deficient hMSC migrated to a distance of approximately 70 µm with a ve- locity of ...
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2012 Association of American Physicians George M Kober LectureTranslating from the rivers of Babylon to the coronary bloodstream
... Blood platelet: the health needs As a fourth-year medical student at New York University School of Medicine in 1970, I developed a sense of the medi- cal importance of blood platelets by my interactions with a patient ...
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Integrin expression and function in osteoblasts
... to integrin engagement of ECM ligands and is suggested to result from integrin cooperation with growth factors (Renshaw et al, ...avp3 integrin receptor (Baron et al, 2002; Borges et al, 2000) and it ...
190
Clinicopathological and prognostic values of fibronectin and integrin αvβ3 expression in primary osteosarcoma
... the integrin family, integrin αvβ3 specifically binds to FN with high affinity ...[9]. Integrin αvβ3 expression is strongly increased in tumor cells, with a prominent role as a pro-angiogenic factor ...
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