Interferon gamma release assay
Screening travellers to high endemic countries for infection with Mycobacterium tuberculosis using interferon gamma release assay; a prospective study
... Interferon gamma release assay (IGRA), commercially available since 2005, is an in vitro T-cell based test which quantifies the immune response of T-cells to in vitro exposure to antigens of ...
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Quality assessment of an interferon gamma release assay for tuberculosis infection in a resource limited setting
... Methods: Interferon-gamma release assay to detect tuberculosis (TB) infection from whole blood was tested in Hanoi, Viet ...for interferon- gamma release using enzyme ...
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Improved sensitivity of an interferon gamma release assay (T SPOT TB™) in combination with tuberculin skin test for the diagnosis of latent tuberculosis in the presence of HIV co Infection
... This study evaluating an interferon-gamma release assay, T-SPOT.TB, in 64 HIV-infected adults who all devel- oped culture-confirmed TB after enrolment in the Swiss HIV Cohort Study indicates ...
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Value of the tuberculin skin testing and of an interferon gamma release assay in haemodialysis patients after exposure to M tuberculosis
... an interferon-gamma release assay (Quantiferon W -TB Gold in-Tube, QFT) for diagnosing LTBI in ESRD patients, after prolonged exposure to a highly contagious TB case in a haemodialysis ...
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Tuberculin Skin Testing and Treatment Modulates Interferon-Gamma Release Assay Results for Latent Tuberculosis in Migrants
... sensitivity assay or a weak immune response may produce initial false negative results, which is enhanced after further antigen exposure ...= interferon-gamma; ESAT-6 = early secretory antigenic ...
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Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: a latent-class analysis
... [4]. Interferon-gamma release assays (IGRAs), including the commercially available assays QuantiFERON-TB Gold In Tube (QFT-GIT; Qiagen, Hilden, Germany), and the ...
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The performance of interferon-gamma release assay in nontuberculous mycobacterial diseases: a retrospective study in China
... (IFN-γ) release assays (IGRAs), such as ...IFN-γ release after stimulation with specific Mycobacterium tuberculosis ...T-SPOT.TB assay is based on response to the ...
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Original Article Positive interferon-gamma release assay results are correlated with paradoxical reaction in tuberculous meningitis
... T-SPOT.TB assay was expressed in terms of sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ...
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Performance of whole blood interferon gamma release assay in patients admitted to the emergency department with pulmonary infiltrates
... Previous studies have shown that host factors that are significantly associated with indeterminate QFT results are immunosuppressive therapies, extremes of age, lym- phocytopenia, hypoalbuminemia, and HIV-infection with ...
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Relation between BCG vaccine scar and an interferon gamma release assay in immigrant children with “positive” tuberculin skin test (≥10 mm)
... The interferon gamma release assays (IGRAs) solve many, but not all, problems in the evaluation of latent TB. They require only one visit, do not cross-react with BCG vaccines and cross-react with ...
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Short-Term Reproducibility of a Commercial Interferon Gamma Release Assay
... T-cell-based interferon gamma release assays (IGRAs) have been shown to be sensitive and highly specific for the detection of Mycobacterium tuberculosis infection ...of gamma interferon ...
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Use of a T cell interferon gamma release assay in the investigation for suspected active tuberculosis in a low prevalence area
... Even in low prevalence regions, TB is a common differen- tial diagnosis in infectious disease practice, and different manifestations of TB may be encountered in all medical disciplines. Whereas most cases of pulmonary ...
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Contribution of a heparin binding haemagglutinin interferon gamma release assay to the detection of Mycobacterium tuberculosis infection in HIV infected patients: comparison with the tuberculin skin test and the QuantiFERON® TB Gold In tube
... the assay without modifying its specificity ...the assay to be considered posi- tive, as this interpretation method has been previously vali- dated and increases the specificity of the test ...
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School based screening for tuberculosis infection in Norway: comparison of positive tuberculin skin test with interferon gamma release assay
... New in vitro assays based on cellular production of inter- feron-gamma (IFN-γ) in response to the M. tuberculosis specific antigens ESAT-6, CFP10, and TB7.7 have been developed. These protein antigens are absent ...
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Specificity of QuantiFERON TB Plus, a New Generation Interferon Gamma Release Assay
... ABSTRACT Interferon gamma release assays (IGRAs) are important tools in identifying prior tuberculosis ...(QFT-Plus) assay, recently approved for use in the United States, differs from the ...
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Risk of latent TB infection in individuals employed in the healthcare sector in Germany: a multicentre prevalence study
... guidelines of occupational safety and health legislation (OSH) HCWs are screened routinely depending on risk assessment. All HCWs working in pulmonary wards and labs (contact with contagious TB-material or TB cases) are ...
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Apoptosis associated biomarkers in tuberculosis: promising for diagnosis and prognosis prediction
... patients will develop the active disease and this risk is even higher in immuno-compromised hosts [7,8]. Now- adays, LTBI is detected by tuberculin skin test and by interferon-gamma release ...
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Use of low-dose computed tomography to assess pulmonary tuberculosis among healthcare workers in a tuberculosis hospital
... CXR: Chest radiography; HCWs: Healthcare workers; IGRA: Interferon-gamma release assay; LDCT: Low-dose computer tomography; PTB: Pulmonary tuberculosis; QFT: QuantiFERON-TB; TB: Tubercul[r] ...
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How to Make a Mudsparkler
... Method: A quality improvement study was designed and implemented to compare baseline testing for new employees with an Interferon-Gamma Release Assay (IGRA) known as QuantiFERON®-TB Go[r] ...
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Prevalence of latent tuberculosis infection in healthcare workers at a hospital in Naples, Italy, a low-incidence country
... Since vaccination data was either not available or in- complete for some participants, all TST-positive cases were then tested also with the QuantiFERON® TB-Gold (QFT) kit (Cellestis, Carnegie, Australia), a second- ...
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