Interleukin 5
Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease
... Like interleukin-4, interleukin-5 is produced by T cells that belong to the Th2 but not the Th1 ...of interleukin-5 production is thought to result from activation of gene transcription ...
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Selectively High Level of Serum Interleukin 5 in a Newborn Infant With Cow's Milk Allergy
... Cow’s milk allergy (CMA) in the neonatal period is thought to include several clinical conditions, yet the pathophysiology remains unclear. We report here the case of a term newborn infant who showed hema- tochezia 36 ...
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In Silico Analysis of the Structural and Biochemical Features of the Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF), Interleukin-3 (IL-3) and Interleukin-5 (IL-5) Receptors Subunit α
... [8]. Interleukin 5 (IL-5) is a hematopoietic growth factor, primarily known as a T-cell-derived cytokine, has pleiotropic effects on different target cells, including eosinophils and B cells, and ...
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Severe eosinophilic asthma: from the pathogenic role of interleukin-5 to the therapeutic action of mepolizumab
... Abstract: Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that has been recently approved as an add-on biological treatment for severe eosinophilic asthma, by both the US ...
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Original Article Expression of interleukin-5 in different pathologic types of nasal polyp tissues
... Abstract: Interleukin-5 (IL-5) exhibits aberrantly high expression in nasal polyps (NP) tissues, which is closely associ- ated with the formation and development of ...
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Extraordinarily High Eosinophilia and Elevated Serum Interleukin-5 Level Observed in a Patient Infected With Paragonimus westermani
... Extraordinarily High Eosinophilia and Elevated Serum Interleukin-5 Level Observed. Services[r] ...
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Anti interleukin 13 and anti interleukin 4 agents versus placebo, anti interleukin 5 or anti immunoglobulin E agents, for children and adults with asthma
... cytokines interleukin-4, -5, and -13 play a central role in the pathophysiology (de Groot ...targeting interleukin-4, -5, and -13, have been developed; the evidence around ...
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Schmid-Lossberg, Juliette (2010): Nachweis von Interleukin-1α, Interleukin-1ß, Interleukin-5 und Interleukin-10 im vaginalen Abstrich von gesunden Frauen. Dissertation, LMU München: Medizinische Fakultät
... Im Gegensatz zu den eben beschriebenen Studien stellte Genc [95] eine Erniedrigung proinflammatorischer Zytokine bei abnormer vaginaler Flora schwangerer Frauen dar. Er analysierte vaginale Abstriche von 205 Frauen in ...
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Detection of Interleukin 5 and 6 on Suspected Patients with Clinical Symptoms of Guttate Psoriasis
... a clinical record of URTI [20]. Cellulitis induced by Streptococcus species and it provokes Guttate Psoriasis [26]. Impetigo was a skin infection caused by Staphylococcus and GABHS species, and it was familiar among ...
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Transcriptional regulation of the mouse and human interleukin-5 genes in T-lymphocytes
... Mast cells participate in the initial events after exposure to allergen, but their importance in orchestrating eosinophilia is uncertain. After IgE-triggered activation, mast cells may promote inflammation of the airways ...
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Nuclear import pathway of the cytokine interleukin-5 and its receptor subunits
... If it does, this should further contribute to the growing idea that polypeptide ligand/receptor nuclear import is a key means of activating specific growth factor and cytokine signalling[r] ...
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Expression of mRNA for interleukin 5 in mucosal bronchial biopsies from asthma
... hybridization signals for IL-5 mRNA were demonstrated within the bronchial mucosa in 6 out of the 10 asthmatic subjects. Cells exhibiting hybridization signals were located beneath the epithelial basement ...
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Relationship between interleukin 5 and eotaxin in regulating blood and tissue eosinophilia in mice
... curs early in the inflammatory response and can be induced in cultured endothelial cells, alveolar epithelial cells, and T cell clones (Th1 and Th2 clones) (17, 18). Taken together, these re- sults suggest that eotaxin ...
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Immune Responses in Human Necatoriasis: Association between Interleukin-5 Responses and Resistance to Reinfection
... 1 5 years old during November–December 1998 (table 1); those subjects were then treated with a single dose of pyrantel pamoate (10 mg/kg of body weight) 0–3 days after blood samples were ob- ...
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Elevated serum interleukin-5 levels in severe chronic obstructive pulmonary disease
... Individual levels of each cytokine are illustrated in Figure 1a, where there were no differences between control and COPD groups, and between COPD severity categories, for most of the cytokines tested. A significant ...
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Transcriptional regulation of the mouse interleukin-5 gene in T lymphocytes
... of 5’ flanking sequence for inducible expression appears to set the mechanism for mIL-5 regulation apart from the related cytokines studied to ...containing 5’ flanking sequences of the cytokine gene ...
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Anti-interleukin-5 therapy in severe asthma
... It is now clear that anti-IL-5 therapies are biologically active and significantly reduce blood and sputum eosinophils and symptomatic exacerbations in patients with severe asthma. It is a promising approach that ...
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Original Article Decrease in serum levels of interleukin-1β, interleukin-5 and interleukin-9 after vitamin D repletion in patients with chronic lymphocytic leukemia
... Abstract: Background: Vitamin D (VD) deficiency in chronic lymphocytic leukemia (CLL) is associated with a worse prognosis, a shorter time to start the treatment and the overall survival. VD deficiency is the first ...
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Interleukin 5 and the posttreatment eosinophilia in patients with onchocerciasis
... To understand the role of the eosinophilopoietic cytokine IL-5 in humans, the posttreatment eosinophilic response in a group of microfilaria (mf)-positive patients with onchocerciasis (n = 10) was examined before ...
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Transcriptional profiling of eosinophil subsets in interleukin 5 transgenic mice
... is rare in wild type (WT) mice, falls at the end of this linear trajec- tory. We identified gene sets that were associated with eosinophil lineage progression and increased Siglec-F expression, which include eosinophil ...
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