ischemic brain damage
CHARACTERISTICS OF HYPOXIC–ISCHEMIC BRAIN DAMAGE
... hypoxic–ischemic brain damage in imma- ture animals when given later than 2 hours after termination of the hypoxic–ischemic insult (see ...hypoxic–ischemic brain damage ...
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Original Article Hyperbaric oxygenation promotes neural stem cell proliferation and protects the learning and memory ability in neonatal hypoxic-ischemic brain damage
... Abstract: The aim of our study was to evaluate whether hyperbaric oxygenation (HBO) was an effective therapy for neonatal hypoxic ischemic brain damage (HIBD). Seven-day-old rat pups were divided ...
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Original Article Granulocyte-colony stimulating factor in combination with AMD3100 confers greater neuroprotection after hypoxic-ischemic brain damage than a solitary treatment in mice
... Abstract: Objective: Hypoxic-ischemic brain damage (HIBD) remains a significant cause of acute deaths and chronic nervous system damage. Granulocyte-colony stimulating factor (G-CSF) has been ...
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Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling
... and ischemic rats and that rapmycin drastically inhibited the phosporylation of P70S6K caused by ...the brain tissues to be vulnerable to ischemic injury by activating the mTOR signaling and that ...
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Expression of Progranulin in a Mouse Model of Newborn Hypoxic-ischemic Brain Damage
... hypoxic ischemic encephalopathy (HIE) is one of the main reasons of death and disability in neonatal, for lack of blood and oxygen during the time of ...the brain can regulate neurite growth and promote ...
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Original Article Bax inhibiting peptide reduces apoptosis in neonatal rat hypoxic-ischemic brain damage
... Abstract: Neonatal hypoxic ischemic encephalopathy (HIE) has been reported to induce apoptosis in neonates. We, therefore, analyzed the ability of Bax-inhibiting peptide (BIP) to provide neuroprotective effects ...
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Inhibition of TRPC6 degradation suppresses ischemic brain damage in rats
... for ischemic damage, and thus preservation of neuronal survival may be important for prevention of ischemic brain ...prevented ischemic neuronal cell death in a rat model of ...to ...
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Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage
... in ischemic stroke, 50,51 autophagy has been recently recognized as a possible deleterious event ...in ischemic brain, 52 mediating ischemic neuronal ...reverse ischemic brain ...
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Vitamin A bio-modulates apoptosis via the mitochondrial pathway after hypoxic-ischemic brain damage
... hypoxic-ischemic damage in vivo and in vitro , and investigated the possible signaling pathway involved in the neuroprotective anti-apoptotic effects of ...hypoxic- ischemic brain ...
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Novel Role of MCP-Induced Protein 1 in Ischemic Brain Damage in Animals of Transient Focal Ischemia
... levels of ZO-1 and claudin-5 were significantly lower in Mcpip1-/- mice as compared to 209. that of wild type after 2 hour ischemia followed by 24 hours reperfusion[r] ...
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Remote ischemic preconditioning in the prevention of ischemic brain damage during intracranial aneurysm treatment (RIPAT): study protocol for a randomized controlled trial
... of ischemic lesions in the pre-interventional MRI will be identified, apparent diffusion coefficient (ADC) and frac- tional anisotropy (FA) values will be measured with region of interest (ROI) technique in ...
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Amelioration of ischemic brain damage by peritoneal dialysis
... or spontaneous poststimulus activations suggestive of seizures (Figure 2E). Functional activation extends to both hemispheres almost symmetrically in intact animals (Figure 2A). The symmetry was lost in pMCAO animals due ...
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Melatonin alleviates brain and peripheral tissue edema in a neonatal rat model of hypoxic-ischemic brain damage: the involvement of edema related proteins
... Several mechanisms of melatonin may be involved in its effects. For example, based on its lipophilic and partly hydrophilic dissolubility, melatonin has a high diffusing capacity, which makes it easy to enter the central ...
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Original Article Proteomic analysis of immature rat pups brain in response to hypoxia and ischemia challenge
... perinatal brain development, even worse in preterm ...permanent brain damage after hypoxia-ischemia attack have not been fully ...hypoxic-ischemic brain damage of immature ...
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The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications
... adult brain largely based on measurements of DNA ...the brain, since several pathways and molecules associated with apoptosis are induced by brain ...the brain in response to the insults ...
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Intrauterine infection/inflammation during pregnancy and offspring brain damages: Possible mechanisms involved
... hypoxic-ischemic brain damage, and/or by inducing the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1 and IL-6 from astrocytes and ...could ...
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Carbon Dioxide Protects the Perinatal Brain From Hypoxic-Ischemic Damage: An Experimental Study in the Immature Rat
... combined with either 0, 3, 6, or 9% carbon dioxide (CO2) for 2.5 hours at 37#{176}C.Survivors underwent neuropatho- logic examination at 30 days of postnatal age, and their brains were c[r] ...
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Selective Brain Cooling with Endovascular Intracarotid Infusion of Cold Saline: A Pilot Feasibility Study
... endovascular brain cooling by means of intra-arterial infusion of cold saline is feasible and safe in the setting of a neuroendo- vascular ...Endovascular brain cooling may constitute a rapid, selective, ...
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Hepcidin, an emerging and important player in brain iron homeostasis
... of brain ischemia and ...the brain in response to TNF-α has been consistently observed in models of inflammation in the brain [27, 56, ...the brain does seem to tip the balance in favor of ...
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Visualization of Irreparable Ischemic Damage in Brain by Selective Labeling of Double-Strand Blunt-Ended DNA Breaks
... irreversibly damaged cells are located scattered throughout the zone. After 24 hr of focal brain is- chemia, cell death and DNA injury are much more pronounced (Fig. 2B). Interestingly, at 24 hr, the dy- ing cells ...
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