Islet amyloid polypeptide
Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus
... Human islet amyloid polypeptide (h-IAPP) is a peptide hormone that is synthesized and cosecreted with insulin from insulin-secreting pancreatic ...pancreatic amyloid deposits in patients with ...
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Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide
... ABSTRACT. Amyloid aggregation of human islet amyloid polypeptide (IAPP) is a hallmark of type 2 diabetes (T2D), a metabolic disease and a global ...of amyloid-β (associated with ...
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Lipid accelerating the fibril of islet amyloid polypeptide aggravated the pancreatic islet injury in vitro and in vivo
... of islet amyloid polypeptide (IAPP) triggered the amyloid deposition, then enhanced the loss of the pancreatic islet ...Pancreatic islet was isolated to evaluate their ...
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Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein
... The amyloid aggregation of human islet amyloid polypeptide (IAPP) and alpha synuclein (αS), specifically, is a hallmark of type 2 diabetes (T2D) and Parkinson’s disease impacting millions of ...
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Autophagy defends pancreatic β cells from human islet amyloid polypeptide induced toxicity
... In prior in vitro studies, we reported that enhancement of autophagy was protective while attenuated lysosomal degradation rendered β cells more vulnerable to h-IAPP–induced apoptosis (15). However, the involvement of ...
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Increased levels of circulating islet amyloid polypeptide in patients with chronic renal failure have no effect on insulin secretion
... of islet amyloid polypeptide (IAPP) with respect to a possible renal elimination we investigated IAPP levels in 20 lean, nondiabetic patients with renal failure maintained on chronic hemodialysis ...
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Does deamidation of islet amyloid polypeptide accelerate amyloid fibril formation?
... Mass spectrometry has been applied to determine the deamidation sites and the aggregation region of the deamidated human islet amyloid polypeptide (hIAPP). Mutant hIAPP with iso-aspartic residue ...
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β Cell–specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity
... using islet lysates obtained from 9-week-old WT, WT:hCAST, hTG, and hTG:h- CAST mice, with average fasting blood glucose of 64 and 76, 96 and 71, 95 and 89, 68 and 62 mg/dl, ...
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Profiling the serum protein corona of fibrillar human islet amyloid polypeptide
... IAPP amyloid-protein corona observed with TEM was corroborated by QCM measurements ...IAPP amyloid displayed cumulative deposition as per ‘classical’ behavior of pathological amyloids in ...IAPP ...
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Effects of Free Fatty Acid on Polymerization of Islet Amyloid Polypeptide (IAPP) In Vitro and on Amyloid Fibril Formation in Cultivated Isolated Islets of Transgenic Mice Overexpressing Human IAPP
... established, amyloid does not appear spontaneously. Instead, islet amyloid appears in these mice after long-term, high-fat dietary intake ...and islet amyloidosis has not been explained but, ...
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Islet Amyloid Development in a Mouse Strain Lacking Endogenous Islet Amyloid Polypeptide (IAPP) but Expressing Human IAPP
... of amyloid is a highly characteristic pancreatic islet abnormality in type 2 ...of islet amyloid in several transgenic mouse strains with very high production of hIAPP have contradicted this ...
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Amyloid Formation in Response to β Cell Stress Occurs In Vitro, but Not In Vivo, in Islets of Transgenic Mice Expressing Human Islet Amyloid Polypeptide
... Therefore, transgenic mice (over)expressing the human IAPP gene, might provide a useful model for studying the mechanisms leading to amyloid deposition in the islets and the possible rol[r] ...
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Key words
... (Ipf1), islet duodenum homeobox-1 (IDX-1), somatostatin transactivating factor-1 (STF-1) or glucose sensitive factor ...other islet-specific genes like Glut-2, islet amyloid polypeptide ...
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Early metabolic predictors for the development of Type 2 diabetes in 1st degree relatives. Results of a 10-year follow-up study (1984-1994), together with cross-sectional analyses in 1994.
... that islet amyloid is present before the onset of hyperglycaemia (De Koning et a/, 1993; O ’Brien et ...of amyloid to progression of diabetes in man is unclear. Islet amyloid is formed ...
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Mechanical Deformation Mechanisms and Properties of Prion Fibrils Probed by Atomistic Simulations
... of amyloid fibrils have been probed by a force spectroscopy based on optical tweezer or AFM, which allows for characterizing the mechanical behavior of protein materials in response to a force ...of amyloid ...
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β-cell insulin receptor deficiency during in utero development induces an islet compensatory overgrowth response
... fetal islet development [9, 11], the discrepancy between results from other studies and the findings presented in our own may be due to the following: (1) knockout timing during development, (2) missing in- depth ...
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Immunosuppression in islet transplantation
... Islet transplantation can temporarily cure type 1 diabetes mellitus (T1DM) but requires simultaneous immunosuppression to avoid allograft rejection. In this issue of the JCI, Monti et al. report that immune ...
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Pancreatic islet transplantation
... that islet transplantation significantly reduces fear of hypoglycemia but have little impact on health-related overall QoL [20], others identified a signif- icant improvement with the use of a diabetes-specific ...
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease
... It is important to note that not all mutations in the central region of Aβ cause CAA, as highlighted by the E693G Arctic and the E693Δ FAD mutations [26,27]. Despite changing the sequence at exactly the same posi- tion ...
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Amyloid tumor of the breast
... an amyloid tumor by an ultrasound-guided vacuum-assisted breast biopsy without ...An amyloid tumor of the breast may show findings suggestive of breast ...
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