JNK inhibitor
The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo
... that JNK is a critical molecule in the biology of human cancer and an attractive target of cancer therapy ...available JNK inhibitors, SP600125 has been used in the overwhelming majority of studies, but the ...
12
Original Article Protective role of JNK inhibitor SP600125 in sepsis-induced acute lung injury
... of JNK inhibition in a rat model of sepsis-induced lung injury, and assessed expression of JNK and endoplasmic reticulum stress-related ...the JNK mRNA levels were measured by ...CLP+JNK ...
11
Original Article Effects of jnk inhibitor on inflammation and fibrosis in the ovary tissue of a rat model of polycystic ovary syndrome
... for JNK in tissue fibrosis are limited. In vitro studies show a role for JNK signaling in TGF-β1-induced fibronectin production in fibro- blasts, and in TGF-β1-induced connective tis- sue growth factor ...
12
Effect of JNK inhibitor SP600125 on hair cell regeneration in zebrafish ( Danio rerio ) larvae
... between JNK and both canonical and noncanonical Wnt signalling pathways have been reported previously in a number of processes in many organisms, including both the promotion and repression of Wnt activity [51–55] ...
11
The impact of JNK inhibitor D-JNKI-1 in a murine model of chronic colitis induced by dextran sulfate sodium
... that JNK-dependent expression of the inflam- matory cytokines TNF- α , IL-6, and transforming growth factor- β 1 (TGFB1) apparently do not play a major role in the present model of mild chronic DSS ...
11
JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin
... ERK, JNK and p38 (1;500), and all of the secondary antibodies used in Western blot analysis were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, ...(ERK inhibitor, 1,4- diamino-2,3-dicyano-1,4-bis ...
13
Activation of c-jun N-terminal kinase in spinal cord contributes to breast cancer induced bone pain in rats
... The JNK inhibitor SP600125 (1,9-Pyrazoloanthrone) was purchased from Calbiochem (San Diego, California, USA). SP600125 stock solution was prepared in DMSO at a concentration 20 μg/μl and stored at -20°C ...
7
ZnO nanoparticle induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
... depolarization, JNK/ ERK/p38 MAPK phosphorylation, and PARP cleavage in cultured primary ...with JNK inhibitor (SP600125), but not ERK inhibitor (U0126) or p38 MAPK inhibitor ...
12
Mucin1 promotes the migration and invasion of hepatocellular carcinoma cells via JNK-mediated phosphorylation of Smad2 at the C-terminal and linker regions
... of JNK is involved in the migration and invasion of HCC cells, the phosphorylation of Smad2L/C and the expression of its target genes were ...siRNAs, JNK inhibitor SP600125 or TβRI inhibitor ...
15
Akt and mTOR mediate programmed necrosis in neurons
... A JNK inhibitor reduced necroptosis in HT22 cells by B50%; however, we did not observe an additive effect of Akt/mTOR/ JNK inhibitors and no effect of extracellular-regulated kinase or P38 ...
11
Original Article Involvement of Bax and caspase-9 in heroin-induced apoptosis in cerebellar granule neurons via C-Jun pathway activation
... and inhibitor groups with Lentiviral, JNK inhibitor SP600125 or CEP1347 to further observe the morphological of cerebellum changes by electron microscopic scanning and studying on the protein ...
16
<p>Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation</p>
... p-JNK, JNK, and β actin. (B) Effect of JNK inhibitor SP600125 on p-JNK LC3BII, DR5, and c-PARP in A549 and in H1299 ...p-JNK, JNK, LC3BII, DR5, c-PARP, and β actin in the ...
15
A Possible Mechanism of Cisplatin Induced Tumor Necrosis Factor (TNF) α Production in Murine Macrophages
... ERK inhibitor (PD98059) suppressed both cis- platin-induced TNF-α mRNA expression and its protein production, a p38 MAPK inhibitor (SB203580) decreased TNF-α protein production ...A JNK ...
6
JNK1 Is Required for Lentivirus Entry and Gene Transfer
... the JNK pathway. JNK is known to play a major role in coordinating cellular responses to ...the JNK path- ...of JNK, c-Jun. In contrast, simultaneous treat- ment with the JNK ...
9
JNK Mediated FOXO Expression Plays a Critical Role in EGFR Tyrosine Kinase Inhibitor Induced BIM Expression and Apoptosis
... AG1478 increased BIM expression through activation of the JNK-FOXO signaling pathway, subsequently re- sulting in cell death. This scenario was substantiated by the knockdown experiment on FOXO1, because its ...
11
Laminar flow inhibits TNF induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14 3 3
... ASK1- ∆ N and ASK1- ∆ NS967A show increased JNK activation. (a) Overexpression of ASK1 proteins in ECs. HUVECs were transiently transfected with control vector, ASK1-WT, ASK1-K709R, ASK1- ∆ N, and ASK1- ∆ NS967A, ...
8
Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer
... Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic inflammation and lung function impairment in ...
18
Original Article Suppression of the CXCL4-JNK pathways contributes to the attenuation of DSS-induced acute colitis in mice
... reader. Equal amounts of protein (p-JNK: 40 μg/20 μl; β-actin: 20 μg/10 μl) were separated by SDS-PAGE and transferred to polyvinylidene fluoride membranes (Milipore, USA). After blocking with TBST (Tris-buffered ...
11
Disulfiram targeting lymphoid malignant cell lines via ROS JNK activation as well as Nrf2 and NF kB pathway inhibition
... Whole protein (50 μg/lane) from each sample was resolved in 10% SDS-polyacrylamide gel electrophoresis (PAGE), transferred to a PVDF membrane (Millipore, UK) and blotted with various antibodies. Non-specific binding was ...
9
Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer
... TAK1 inhibitor 5Z-7-Oxozeaenol (5Z-O) inhibited TAK1 activity, suppressed downstream signaling pathways including p38, IκB kinase (IKK) and c-Jun N-terminal kinase (JNK) and reduced CCR7 expression in ...
13