JNK/SAPK
Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells
... of SAPK/JNK to pre-treated cells to examine the role of the kinase in mediating the effect of UA on reduction of DNMT1 and ...of SAPK/JNK (SP600125) abro- gated UA-reduced DNMT1 and EZH2 ...
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Fries, Florian (2018): Die Caerulein-induzierte akute Pankreatitis am Mausmodell: Auswirkung auf die Inflammation nach Hemmung der SAPK/JNK MAP-Kinase in nicht-transgenen und MK-2 -/- Mäusen. Dissertation, LMU München: Medizinische Fakultät
... von SAPK/JNK Inhibitor zusammen mit MK-2 (-/-) (Behandlung 3) eine signifi- kante Veränderung gegenüber nicht-transgenen Caerulein-Mäusen (Behandlung 2) bringt, kann mit Ja beantwortet ...der ...
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Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I
... of SAPK/JNK signaling in the effect of PPI on inhibition of DNMT1 and ...of SAPK/JNK decreased DNMT1 expression, thereby inhibiting growth in colon cancer cells ...as SAPK/JNK, ...
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<p>Knockdown of EIF3C promotes human U-2OS cells apoptosis through increased CAS P3/7 and Chk1/2 by upregulating SAPK/JNK</p>
... and SAPK/JNK, indicating that the downregulated expression of EIF3C might be associated with pro-apoptosis of U-2OS ...proliferation, SAPK/JNK, ...
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Immunotoxicity of titanium dioxide nanoparticles via simultaneous induction of apoptosis and multiple toll-like receptors signaling through ROS-dependent SAPK/JNK and p38 MAPK activation
... To unveil the downstream signaling targets of activated TLRs and/or ROS/RNS on TiO 2 NP-induced immuno- toxicity in murine macrophage, Western blot on mitogen- associated protein kinases (MAPK) was done. We found that ...
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Combination of curcumin and bicalutamide enhanced the growth inhibition of androgen-independent prostate cancer cells through SAPK/JNK and MEK/ERK1/2-mediated targeting NF-κB/p65 and MUC1-C
... and SAPK/JNK signaling pathways in the regula- tion of p65 and MUC1-C affected by ...and SAPK/JNK by ...of SAPK/JNK inhib- ited NF-κB signaling via a feedback loop mechanism that ...
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JNK and p38 Mitogen-Activated Protein Kinase Pathways Contribute to Porcine Circovirus Type 2 Infection
... of JNK/SAPK and p38 MAPK activation prevents PCV2-mediated caspase ...of JNK and p38 inhibitors on PCV2 spliced cap mRNA synthesis in infected ...with JNK inhibitor 1 or SB202190 at the ...
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Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells
... phospho-specific SAPK/ JNK, SAPK/JNK, phospho-specific STAT3, STAT3 and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) antibodies were purchased from Cell Signaling Technol- ogy (Beverly, ...
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Differential Activation of MAP Kinase Signaling Pathways and Nuclear Factor-κB in Bronchoalveolar Cells of Smokers and Nonsmokers
... These assays were performed using commercial kits (New England Biolabs Inc.) following the instruc- tions of the manufacturer. Briefly, the p44/42 (ERK2/1) and p38 MAP kinase assays were carried out by incubating the ...
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12/15 Lipoxygenase inhibition counteracts MAPK phosphorylation in mouse and cell culture models of diabetic peripheral neuropathy
... Unless otherwise stated, all chemicals were of re- agent-grade quality, and were purchased from Sigma Chemical Co., St. Louis, MO, USA. Cinnamyl-3,4- dihydroxy-alpha-cyanocinnamate (CDC) was obtained from Enzo Life ...
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Exercise intensity and glycaemic control : the role of redox status and redox-sensitive protein kinase signalling in humans
... of JNK, p38 MAPK, NF-κB, and protein kinase C (PKC) signalling pathways in skeletal ...and SAPK signalling, yet glycaemic control and skeletal muscle function are ...of SAPK signalling in the ...
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Jun N terminal kinase maintains tissue integrity during cell rearrangement in the gut
... and JNK activity (phosphoJun) is evident in extracts from JNK MO-injected (mosaic) guts, compared with Cont MO-injected gut ...or JNK MO-injected embryos reveal the localization of atypical protein ...
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Reovirus Infection Activates JNK and the JNK-Dependent Transcription Factor c-Jun
... Reovirus-induced JNK activation is associated with an increase in the phosphory- lation of the JNK-dependent transcription factor ...more JNK activation and c-Jun phosphorylation than does the ...
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JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin
... JNK inhibitor suppressed the inhibitory effect of melittin and bee venom on the nuclear translocation of the p50 subunit and the release of IκB induced by LPS or SNP. Raw 264.7 cells (A) or synoviocytes (B) were ...
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<p>Metformin Inhibits Proliferation of Human Thyroid Cancer TPC-1 Cells by Decreasing LRP2 to Suppress the JNK Pathway</p>
... Results: Viability in TPC-1 cells gradually decreased with the treatment of increased doses of metformin either for 24 h or 48 h. The apoptotic rate was concentration-dependently elevated by metformin treatment. Relative ...
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The expression of p ATF2 involved in the chondeocytes apoptosis of an endemic osteoarthritis, Kashin Beck disease
... human JNK, p38, ATF2 and GAPDH with the following cycling conditions: 94°C for 2 mins, 94°C for 10 s, 58°C for 30 s, and 72°C for 30 s for 40 cycles, followed by a melting curve ...of JNK, a 107-bp fragment ...
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<p>Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation</p>
... p-JNK, JNK, and β actin. (B) Effect of JNK inhibitor SP600125 on p-JNK LC3BII, DR5, and c-PARP in A549 and in H1299 ...p-JNK, JNK, LC3BII, DR5, c-PARP, and β actin in the ...
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A Novel Function for Hog1 Stress-Activated Protein Kinase in Controlling White-Opaque Switching and Mating in Candida albicans
... Hog1 SAPK pathway in mediating white-opaque ...Hog1 SAPK pathway to determine if these factors function in regulating this unique phenotypic transition in the human fungal pathogen ...
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Role of JNK and ERK1/2 MAPK signaling pathway in testicular injury of rats induced by di-N-butyl-phthalate (DBP)
... p-ERK1/2, JNK, p-JNK, P38, p-P38 and tubulin monoclonal antibody (Beijing Solarbio, China) were added, shaken at 37 °C for 1 h, Washed three times with phosphate buffer solution- Tween 20 for 10 ...
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JNK suppresses pulmonary fibroblast elastogenesis during alveolar development
... in JNK-deficient lung fibroblasts (Figure ...and JNK-deficient lung fibro- blasts (Figure ...that JNK regulates many of the genes involved in elastin microfibril formation and support the concept ...
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