Key Genes
Identification of potential key genes associated with ovarian clear cell carcinoma
... In the present study, five gene expression datasets were retrieved from GEO, including microarray information of 27 OCCC samples and 30 normal ovary samples. Gene expres- sion and protein–protein expression analyses ...
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Comprehensive analysis of key genes and microRNAs in radioresistant nasopharyngeal carcinoma
... discovered to be involved in radioresistant NPC, whereas traditional methods have failed to elucidate the interaction of mRNAs and microRNAs and the molecular mecha- nisms of NPC due to the limitations on the comparative ...
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Analysis of potential key genes in very early hepatocellular carcinoma
... numerous genes alterations ...potential key genes in the occurrence of HCC by comparing the expression profiles of very early HCC tissue with that of chronic cirrhotic tissue samples by integrating ...
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<p>Identification of key genes and pathways in seminoma by bioinformatics analysis</p>
... harmful substances. However, it is dif fi cult to maintain a normal structure and function in cancer tissue. Moreover, studies have suggested that the loss of cell cycle regulation leads to genomic instability, and the ...
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Identification and interaction analysis of key genes and microRNAs in hepatocellular carcinoma by bioinformatics analysis
... Increasing evidence has shown that the dysregulation of miRNAs is an important part of the pathogenesis of multiple cancer types, including HCC. In our study, we identified 64 DEMs, including 58 up-regulated and 6 ...
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Identification of key genes and miRNAs markers of papillary thyroid cancer
... miR-7-2 was another down-regulated DEM associated with clinical stage. Based on a functional enrichment analysis, the target genes of miR-7-2, such as CLDN1, were significantly enriched for hsa04530: tight ...
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Comparative analysis of targeting key genes in stat pathway in k562 cells
... individual genes were silenced in K562 cells, the gene expression reduced to a greater extent at 48 hours’ time ...three genes in this ...other genes were silenced in this ...
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Identification of key genes and pathways using bioinformatics analysis in septic shock children
... STRING (version 10.5) database currently covers 9,643,763 proteins from 2,031 organisms. To assess the interactive rela- tionships, the identified DEGs were mapped via STRING, and the experimentally validated ...
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Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma
... in AURKB, KIF2C, BUB1B, HMMR, CENPF, and CENPU genes among lung cancer ranged from 1.3% to 9% in individual genes (AURKB, 1.3%; KIF2C, 2.1%; BUB1B, 3%; HMMR, 1.9%; CENPF, 9%; CENPU, 4%) (Figure 7). In ...
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Integrated network analysis to explore the key genes regulated by parathyroid hormone receptor 1 in osteosarcoma
... In rat bone marrow stromal cells (BMSCs), neuro- trophic factors, NURR1 (also named NR4A2), tyrosine hydroxylase (TH), and nestin genes have spontaneous expression [26]. NURR1 and NURR77 may contribute to increase ...
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Functional genetic validation of key genes conferring insecticide resistance in the major African malaria vector
... other genes that are not up-regulated in the sensitive genetic background of the ...detoxification genes using the Ubi-A10GAL4:UAS-e2 (integration) ...
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Identification of key genes involved in myocardial infarction
... Gene expression data were first downloaded from each dataset, and the expression levels of genes in each sam- ple were extracted from Series Matrix File(s). And then, R was used to pre-process the downloaded raw ...
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Prediction of key genes and pathways involved in trastuzumab resistant gastric cancer
... CD44, a key cancer stem cell (CSC) marker, was downreg- ulated in trastuzumab-resistant breast cancer and associated with the trastuzumab resistance in GC. [57]. Previously, high expression of CD44 correlated with ...
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Epigenetic Control of Learning and Memory in Drosophila by Tip60 HAT Action
... target genes are enriched for functions in cognitive processes, and, accordingly, key genes representing these pathways are misregulated in the Tip60 HAT mutant fl y ...
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<em>ANLN </em>functions as a key candidate gene in cervical cancer as determined by integrated bioinformatic analysis
... Results: GSE29570 and GSE89657, including 49 cervical cancer tissues and 20 normal cervical tissues, were screened as the datasets. Three-hundred-twenty-four DEGs were identified and, among them, 123 were upregulated, ...
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Tumor-host signaling interaction reveals a systemic, age- dependent splenic immune influence on tumor development
... essential genes involved with either the tumor or non-tumor bearing mice, the overlap of genes from the above analysis was compared to the genes involved with GSEA analysis ...four key ...
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Genome-wide Analyses on Single Disease Samples for Potential Biomarkers and Biological Features of Molecular Subtypes: A Case Study in Gastric Cancer
... identified key genes of each subtype The genome-wide co-expression network of each subtype was constructed using its preprocessed microarray gene expression ...
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Selection of reference genes for diurnal and developmental time course real time PCR expression analyses in lettuce
... reference genes for normalising target gene expression should be the first step in any expression study to avoid inaccurate ...candidate genes were tested for their suitability for use as reference ...
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TCF4/beta-Catenin Complex Activates Smo and Gli1 to Promote Migration and Proliferation of Hepatocellular Carcinoma Cells
... of key genes in these 2 pathways were analysed. Wnt signalling genes (Wnt3, TCF7, and FZD8) and Hh signalling genes, Smo, Gli1, Gli2 and Gli3 were collected and their expression levels were ...
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Control and target gene selection for studies on UV induced genotoxicity in whales
... control genes in skin biopsies and found that the genes coding for the tyrosine 3-monoxygenase ( YWHAZ ) and glyceraldehyde-3P -dehydrogenase ( GAPDH ) were the most reliable ones followed by those coding ...
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