LARGE-TUMOR-ANTIGEN
p300 family members associate with the carboxyl terminus of simian virus 40 large tumor antigen.
... Several cellular polypeptides critical for growth regulation interact with DNA tumor virus oncoproteins. p400 is a cellular protein which binds to the adenovirus E1A oncoprotein(s). The biological function of p400 ...
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Complex formation between the lymphotropic papovavirus large tumor antigen and the tumor suppressor protein p53.
... 5417-5424 0022-538X/91/105417-08$02.00/0 Copyright © 1991, American Society for Microbiology Complex Formation between the Lymphotropic Papovavirus Large Tumor Antigen and the Tumor Supp[r] ...
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CD4+ T Lymphocytes Are Critical Mediators of Tumor Immunity to Simian Virus 40 Large Tumor Antigen Induced by Vaccination with Plasmid DNA
... protein large tumor antigen (Tag), which plays a critical role in viral replication and also inactivates host p53 and retinoblastoma family tumor suppressor ...
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The block of adipocyte differentiation by a C-terminally truncated, but not by full-length, simian virus 40 large tumor antigen is dependent on an intact retinoblastoma susceptibility protein family binding domain.
... targeting tumor suppressors such as p53 and members of the retinoblastoma susceptibility protein (Rb) ...SV40 large tumor antigen (SVLT) suppresses adipocyte ...small tumor ...
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The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions.
... After incubation for 4 h, the cells were washed 5459 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The large tumor antigen T antigen of simian virus 40 is necessary a[r] ...
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Role of the Innate Immune Response and Tumor Immunity Associated with Simian Virus 40 Large Tumor Antigen
... the tumor-specific antigen simian virus 40 (SV40) large tumor antigen (Tag) following experimental pulmonary metastasis in naive ...mKSA tumor cell challenge, expression of ...
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Intestinal Hyperplasia Induced by Simian Virus 40 Large Tumor Antigen Requires E2F2
... T antigen (n ⫽ 17) to induce intestinal hyperplasia ...T antigen was not diminished by the absence of E2F1 ...T antigen in the presence of E2F2 ...
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Subcellular Localization of Simian Virus 40 Large Tumor Antigen
... The 96,000-molecular-weight anti-T-reactive surface protein was present in SV40-transforned mouse and hamster cells, as well as in productively infected monkey cells, but was not detecte[r] ...
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The replication functions of polyomavirus large tumor antigen are regulated by phosphorylation.
... Treatment with smaller quantities of CUAP stimulated the ability of the viral protein to mediate replication of constructs containing the viral replication origin, while higher concentra[r] ...
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Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA.
... We can speculate that, although the newly synthesized 5 to 7S T antigen form is the active viral origin-binding form, the subsequently formed more rapidly sedimenting T antigen oligomers[r] ...
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Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutations.
... Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen are defective for binding cellular protein p53.. The replication functions of SV40 T antig[r] ...
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Common and unique features of T antigens encoded by the polyomavirus group.
... Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen are defective for binding cellular protein p53.. Mutations near the carboxyl terminus of t[r] ...
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Phenotype-specific phosphorylation of simian virus 40 tsA mutant large T antigens in tsA N-type and A-type transformants.
... 4414 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To identify molecular differences between simian virus 40 SV40 tsA58 mutant large tumor antigen large T in cells of[r] ...
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Mutual functional antagonism of the simian virus 40 T antigen and the hepatitis B virus trans activator.
... Positive and negative regulation of transcription in vitro: enhancer binding protein AP-2 is inhibited by SV40 T antigen.. Production of simian virus 40 large tumor antigen in bacteria: [r] ...
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Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation.
... We report here the isolation and characterization of in vitro-constructed amino acid substitu- The large tumor antigen T antigen of simian virus 40 SV40 is a regulatory protein that is e[r] ...
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Three domains in the simian virus 40 core origin orchestrate the binding, melting, and DNA helicase activities of T antigen.
... Simian virus 40 large tumor antigen requires three core replication origin domains for DNA unwinding and replication in vitro.. Simian virus 40 SV40 DNA replication: SV40 large T antigen[r] ...
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A DNA replication-positive mutant of simian virus 40 that is defective for transformation and the production of infectious virions.
... The large tumor antigen T antigen of simian virus 40 SV40 is a multifunctional regulatory protein that is required for a number of steps in productive viral infection, including DNA repl[r] ...
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Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen.
... 2014 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We generated fragments of simian virus 40 large tumor antigen T antigen by tryptic digestion and assayed them for h[r] ...
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Monoclonal antibodies as probes for a function of large T antigen during the elongation process of simian virus 40 DNA replication.
... 411 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Various monoclonal antibodies specific for simian virus 40 large tumor antigen T antigen inhibit the elongation proc[r] ...
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Differential induction of structural changes in the simian virus 40 origin of replication by T antigen.
... 1228 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The ATP-dependent binding of the simian virus 40 SV40 large tumor antigen T antigen to the SV40 origin of replicati[r] ...
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