LC-ESI/MS/MS
Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS
... Vandetanib (Caprelsa tablets, VNT) is an orally inhibitor of vascular endothelial growth factor receptor 2. The current research reports the characterization and identification of in vitro, in vivo and reactive ...
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Simultaneous Determination of Ten Endocrine Hormone Disrupters in Water Using SPE/LC (ESI)MS MS
... Between May and June 2008, 43 samples were collected from several sampling points of the EPAL water supply system and also from the main raw water sources of this company (Tagus River, Castelo de Bode reservoir, and ...
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Measurement of methionine level with the LC-ESI-MS/MS method in schizophrenic patients
... Case selection. Schizophrenia patients and healthy controls were included in this study, with the aim of evaluating the LC-ESI-MS/MS method with regard to the measurement of plasma methionine ...
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Development and Validation of a LC-ESI-MS/MS Based Bioanalytical Method for Dapagliflozin and Saxagliptin in Human Plasma
... sensitive LC-ESI –MS/MS method for the simultaneous estimation of Dapagliflozin and saxagliptin in human K 2 EDTA plasma by Liquid –liquid Extraction method (LLE) using deutereated ...
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Phytochemical Study of Nothapodytes foetida by LC-ESI-MS
... reproducible LC-MS method has been developed for quantification of camptothecin (CPT), a potent cytotoxic isoquinoline alkaloid, in methanol extract from these different parts of Nothapodytes foetida using ...
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Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum
... Figure 2 demonstrates that the signal of the gut metabolites is in the same order of magnitude and the gut metabolites are coeluting with their deuterated internal standards, which is required for absolute ...
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Phytochemical Diversity in Rhizomes of Three Reynoutria Species and their Antioxidant Activity Correlations Elucidated by LC-ESI-MS/MS Analysis.
... Abstract: One of the richest natural sources of resveratrol - the rhizome of Reynoutria japonica in East Asia is a well-known traditional herb (Hu zhang) used in various inflammatory diseases, infections, skin diseases, ...
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Estimation of Ribociclib in Human Plasma Samples by LC ESI MS/MS
... A validated Ribociclib bioanalytical method was developed by HPLC-ESI-MS/MS using stationary phase Zorbax SB-C18, 4.6 × 75 mm, 3.5 μm, 80 Å column and mobile phase was used 5mM ammonium formate: ...
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Rapid LC ESI MS MS Method for the Simultaneous Determination of Sitagliptin and Pioglitazone in Rat Plasma and Its Application to Pharmacokinetic Study
... monitoring (MRM) for detection of individual species from a complex mixture, Characterization and quantitation of metabolites more quickly and easily. The positive ion electrospray ionization (ESI) mode selected ...
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Proteome analysis of excretory-secretory proteins of Entamoeba histolytica HM1:IMSS via LC–ESI–MS/MS and LC–MALDI–TOF/TOF
... Liquid chromatography and MALDI mass spectrometry The separation of peptides prior to MALDI–TOF/TOF was performed using eksigent nanoLC ultra 1D plus (Eksigent,Germany) linked to an automated spotter (Eksigent, Germany). ...
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Simultaneous quantification of six major flavonoids from Fructus sophorae by LC-ESI-MS/MS and statistical analysis
... Dikma Technologies Inc., Lake Forest, CA, USA. Purified water was obtained from Wahaha (Hangzhou Wahaha Group Co. Ltd., Hangzhou, China). Analytical grade dehydrated ethanol (Tianjin Chemical Corporation,Tianjin, China) ...
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Picogram Level Quantification of Grazoprevir and Elbasvir with Deuterated Internal Standards in Human Plasma Samples by LC–ESI-MS/MS
... The main goal of the present study is to develop and validate the novel simple, sensitive, selective, rapid, rugged and reproducible analytical method for quantitative determination of Elbasvir and Grazoprevir in human ...
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Picogram level quantification of Afatinib in human plasma samples by LC–ESI MS/MS
... is important to develop the superior bio analytical method with proper deuterated or analogue based internal standards interms of matrix effect and reproducibility. Moreover, Should not consider the runtime always to ...
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A validated LC-ESI-MS/MS method for the quantification of Selegiline HCl in bulk and pharmaceutical formulation
... novel LC-MS/MS method was developed and validated which can be applied for the quantification of Selegiline HCl in a pharmaceutical formulation which offers excellent accuracy and significant ...
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PICOGRAM LEVEL QUANTIFICATION OF VARENICLINE IN HUMAN PLASMA SAMPLES BY LC–ESI MS/MS
... samples. LC-MS/MS has been used as one of the most powerful analytical tool in clinical pharmacokinetics for its selectivity, sensitivity and ...The MS optimization was performed by direct ...
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Liquid Chromatography Tandem Mass Spectrometry Method for Determination of Anti Diabetic Drug Repaglinide in Human Plasma
... A highly sensitive, accurate and rapid analytical method based on reversed-phase liquid chroma- tography/electrospray ionization tandem mass spectrometry (RP-LC-ESI-MS/MS) has been devel- oped ...
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Development and evaluation of an immuno-MALDI (iMALDI) assay for angiotensin I and the diagnosis of secondary hypertension
... and MS-based approaches for Ang-I deter- mination have been of great interest because of their ...Published MS-based methods have used solid- phase extraction (SPE) and positive ion ...
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Guarapiranga Reservoir—Pharmaceuticals and Historical Urban Occupation in a Water Source
... The pharmaceutical compounds were analyzed in 14 sampling sites and pointed out the pollution sources related to raw sewage input and urban drainage dis- charge. Five medicine compounds, one illicit drug, and its ...
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In Vitro Metabolism Study of Brevetoxins by LC-ESI-MS
... We postulate that brevetxin-2-M2 is formed by metabolic reduction of the tail (addition of two hydrogen atoms to the aldehyde), thereby forming brevetoxin-3. To confirm the postulation that the peak at 7.8 min ...
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The Quest for Renal Disease Proteomic Signatures: Where Should We Look?
... or ESI-IT MS/MS in patients with IgA nephropathy and healthy ...used LC-ESI-MS/MS to analyze plasma albumin from patients with active FSGS or other glomerular disorders ...
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