LC-MS/MS
BIO ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR OMEPRAZOLE USING LC MS/MS
... the LC-MS/MS it is understood that the method used for preparation and detection of omeprazole is valid and this technique can be employed further for detection of ...
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Elucidating the Secretome of Lung Spheroid Cells using LC/MS/MS.
... proteins, and enzymes which is consistent with the proteins present in the conditioned media that were classified as cytoplasmic. Folding proteins such as calreticulin, heat shock 70kDa protein, elongation factor 1-alpha ...
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A simple and rapid determination of candesartan in human plasma by LC-MS/MS
... Sample processing protocol: An aliquot of 50 µL of thawed human plasma sample was mixed with 10 μL of the internal standard working solution (2140 ng/mL of candesartan d4). To this, 50 μL of 2% formic acid solution was ...
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Phytoestrogens in bovine plasma and milk – LC MS/MS analysis
... Chromatographic and detection conditions High performance liquid chromatography coupled to ion trap mass spectrometer was employed for the separation and detection of daidzein, genistein, and equol in bovine plasma and ...
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A validated LC-MS/MS method for the pharmacokinetic study of alogliptin in healthy rabbits
... A liquid chromatography-tandem mass spectrophotometric (LC-MS/MS) method was developed for quantification of Alogliptin in rabbit plasma employing Liquid-Liquid extraction technique. The developed ...
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Rapid detection of colistin resistance protein MCR-1 by LC–MS/MS
... by LC–MS/MS ...Lumos LC–MS/MS, employing both data dependent analysis (DDA) and targeted approaches, was used to identify efficiently ionized and reliably detected unique MCR-1 ...
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ESTIMATION AND VALIDATION FOR DETERMINATION OF ROSUVASTATIN IN HUMAN PLASMA BY LC/MS/MS METHOD
... 481.538g/mol. Rosuvastatin is a competitive inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early rate- limiting step in cholesterol biosynthesis. Decreased hepatic ...
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Determination of Clopidogrel Carboxylic Acid in Human Plasma by LC MS/MS
... sensitive LC/MS/MS assay method for the determination of Clopidogrel carboxylic acid in human plasma using Clopidogrel-D4-carboxylic acid as internal ...
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A LC/MS-MS Guided Isolation of Laccaic Acid-A: A Potent Antimicrobial Agent
... in LC-MS/MS to identify the active constituent from ...effective LC-MS/MS run to identify the active constituent as laccaic acid-A in both the ...
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VALIDATION OF LC-MS/MS METHOD FOR THE QUANTIFICATION OF NORETHINDRONE IN HUMAN PLASMA
... A high-performance liquid chromatographic mass spectrometric method for the estimation of NOR in human plasma has been developed and validated according to the principles of Good Laboratory Practices. The plasma was ...
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NEWLY DEVELOPED AND VALIDATED METHOD FOR AZITHROMYCIN BY LC/MS-MS
... To the vials containing pipetted samples 3mL of organic mixture was added and vortexed. The samples were extracted for 10 min at 2000 rpm in vibromax and centrifuged for 10 min at 4000 rpm at 4°C. 2.4 mL of upper organic ...
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A VALIDATED LC MS/MS METHOD FOR PHARMACOKINETIC STUDY OF AFATINIB IN HEALTHY RABBITS
... (LC– MS/MS) method was developed for quantification of Afatinib in rabit plasma employing Solid Phase Extraction (SPE) ...developed LC-MS method was applied to assess pharmacokinetics ...
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Investigations of the Copper Peptide Hepcidin-25 by LC-MS/MS and NMR
... LC-MS/MS experiments were carried out on an Agilent 1260 Infinity LC system coupled to a Triple Quad™ 6500 MS (AB Sciex, Darmstadt, Germany). Electrospray ionization was performed in ...
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LC-MS/MS method for the detection of multiple classes of shellfish toxins
... Abstract: Marine shellfish toxins are seafood safety problems of global concern. Herein the analysis of six shellfish toxins, regulated by European Union, with one single run by LC-MS/MS with acidic ...
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LC MS/MS STUDIES ON THE FRUIT EXTRACTS OF MORINDA CITRIFOLIA L (NONI)
... Introduction: Morinda citrifolia L (Noni) has been extensive history of medicinal uses among the traditional therapeutic action in 2000 years ago. It’s belongs to Rubiaceae family and commonly known as Indian Mulberry. ...
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METHOD DEVELOPMENT AND VALIDATION OF RESIDUES OF PESTICIDES IN RICE BY USING LC – MS/MS
... A rapid and sensitive method was developed and validated for the determination of around 100 pesticides in rice samples by using HPLC coupled to a triple quadruple detector mass analyser (LC-MS/MS) ...
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Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics
... A number of reviews have been published that cover many diverse metabolomics topics including chromatography, data processing and statistics in great detail [16–24]. We mostly focus on papers that discuss structure ...
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Stability indicating lc ms/ms method for determination of teicoplanin in human plasma
... A rapid, simple, selective and sensitive LC-MS/MS method was developed for the determination of Teicoplanin in human plasma using Imipramine as internal standard (IS). The method was developed with ...
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THERAPEUTIC EFFICACY OF HYDROCHLOROTHIAZIDE WITH LOSARTAN AS A FIXED DOSE COMBINATION BY LC-MS/MS
... examined. LC-MS/MS technique is used to determine the concentration of Losartan, Losartan Carboxylic acid and HCTZ in human plasma after the administration of the drugs for fixed dose pharmacokinetic ...
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LC-MS/MS method for determination of potential genotoxic impurities in imatinib mesylate
... Shimadzu SIL-HTC separation module (Shimadzu Corporation) equipped with API 2000-LC-MS/MS (MDS SCIEX) with Analyst software was used for the analysis. YMC-Basic column (250 X 4.6 mm, 5um YMC ...
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