LDL-R
Aerobic exercise training protects against endothelial dysfunction by increasing nitric oxide and hydrogen peroxide production in LDL receptor deficient mice
... Background: Endothelial dysfunction associated with hypercholesterolemia is an early event in atherosclerosis char- acterized by redox imbalance associated with high superoxide production and reduced nitric oxide (NO) ...
15
Regulatory effect of Phikud Navakot extract on HMG CoA reductase and LDL R: potential and alternate agents for lowering blood cholesterol
... For assessing the effect of PNEF, PNWF, NYEF, NYWF, NBEF and NBWF on the expressions of HMGCR and LDL-R, HepG2 cells were seeded at 1 × 10 6 cells/ml and cultured in DMEM complete medium for 24 h before ...
8
In Defense of the LDL Hypothesis
... ↓ Obser = Observation time too short. No CRP? = Failure to monitor or normalize the concomitant change in C-reactive protein. LDL Rcpt = Use of an LDLc lowering agent that does not increase hepatic LDL re- ...
8
Defective metabolism of hypertriglyceridemic low density lipoprotein in cultured human skin fibroblasts Normalization with bezafibrate therapy
... of LDL receptor activity, up-regulated cells were incubated for 48 h with HTG-LDL and ...BZ-LDL. LDL receptor activity was significantly higher after preincubation with HTG-LDL compared ...
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Original Article Peripheral Th17/Treg imbalance in patients with atherosclerotic cerebral infarction
... ox- LDL when compared to those in TIA and control ...ox- LDL results in the aggravation of the Th17/Treg imbalance, which promotes atherosclerotic plaque formation/destabilisation in ...
13
Survival benefit of a low ratio of visceral to subcutaneous adipose tissue depends on LDL clearance versus production in sepsis
... their LDL levels at base- line (considering no statin treatment and PCSK9 wild- type genotype ...of LDL levels was associated with increased ...low LDL is associated with worse outcomes ...of ...
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Cutaneous xanthoma in association with paraproteinemia in the absence of hyperlipidemia
... The LDL-antibody complex isolated from our patient did not affect the degradation of LDL by human fibroblasts, indicating that while IgG derived from our patient interacted with LDL it did not alter ...
8
Impact of dyslipidemic components of metabolic syndrome, adiponectin levels, and anti-diabetes medications on malondialdehyde-modified low-density lipoprotein levels in statin-treated diabetes patients with coronary artery disease
... oxidized LDL receptor-1 by remnant lipoprotein particles induces nicotinamide adenine di- nucleotide phosphate (NADPH) oxidase-dependent pro- duction of superoxide in endothelial cells [35], which may explain the ...
10
Insights into regulation of lipoprotein receptors in human mesangial cells: The effects of inflammatory cytokines and calcium channel blockers.
... haemodynamic, increased oxidisability of LDL, recruitment of monocytes, proliferation of SMC and formation of fibrous tissue. The similarity between atherosclerosis and glomerulosclerosis is based on the ...
271
Development of Capture Assays for Different Modifications of Human Low-Density Lipoprotein
... with LDL isolated from athero- sclerotic plaques (16, ...including LDL (AGE-LDL) have also been shown to be immunogenic ...modified LDL have also been extensively characterized (28) and shown ...
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The Effects of Lipophilic Antioxidants on the Affinity of LDL to Its Receptor: A Model for Prevention of Atherogenesis
... plasma LDL is a heterogeneous collection of particles that varies in size [20], density [21], composition [22], and electrical charge ...Some LDL forms are more atherogenic than other [24, ...human ...
5
The Application of the LDL Principle
... The LDL Principle has recently been invoked to describe the observation that lowering the LDL cholesterol (by whatever means) results in a lowering of atherosclerotic cardiovascular ...the LDL ...
17
The New Molecular Entity Evolocumab, One Kind of PCSK9 Inhibitor, Reduce Plasma Small Size LDL Cholesterol Levels by Using a New Standardized Method of Measuring LDL Size
... smaller-sized LDL have been proposed [24] ...enriched LDL, the favored substrate for hepatic lipase, which is transformed into smaller-sized LDL by lipase-mediated TG hydrolysis ...as LDL ...
23
Effect of dietary tocotrienols (Tocomin) and lovastatin on ex vivo and Cu++ mediated in vitro susceptibility of LDL, sd LDL and lb LDL to oxidation in absence or presence of glucose in diabetic hyperlipidemic rats
... of LDL, may act either as antioxidant or prooxidant, depending on the LDL associated α-tocopherol content, our ex vivo and in vitro results also show similar dual effect of glucose on the oxidative ...
10
Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and their mechanisms of action on apolipoprotein B-containing lipoproteins in humans: a review
... on LDL was dependent on APOE genotype ...significant, LDL-C levels tended to increase more in APOE4 carriers than in APOE2 or APOE3 carriers fol- lowing OM3FA ...dense LDL levels decreased similarly ...
13
Native low density lipoprotein induced calcium transients trigger VCAM 1 and E selectin expression in cultured human vascular endothelial cells
... of LDL increases its ...native LDL (n-LDL) binding to the LDL receptor (100–700 m g/ml) triggers a rise in intracellular calcium which acts as a second messenger to induce vascular cell ...
13
Lipoprotein lipase mediated uptake and degradation of low density lipoproteins by fibroblasts and macrophages
... increases LDL binding to cells, bovine milk LPL was added to upregulated and nonupregulated human fibroblasts along with media containing ...LDL. LDL binding to cells was increased 2-10-fold, in a ...
10
Low density lipoproteins and haemodynamic changes in the isolated perfused rat kidney
... To elucidate the possible role o f nitric oxide (NO), urinary cGMP, nitrate and nitrite excretion were measured during N-LDL and Ox-LDL infusion. There was a significant decrease in urinary excretion o f ...
365
Evaluation of pathways for the cellular uptake of high density lipoprotein cholesterol esters in rabbits
... A-I, LDL apo B, and VLDL CE were simultaneously injected ...E, LDL, and ...to LDL and VLDL, 20% were cleared directly from the HDL pool without HDL particle ...
17
Evaluation of different formulas for LDL-C calculation
... for LDL-C ...mean LDL-C concentrations were ...measured LDL-Cs (r > ...for LDL-C estimation (S-LDL-C) showed no statistically significant difference compared to ...for ...
9