Leptin Receptors
Long-term fructose feeding changes the expression of leptin receptors and autophagy genes in the adipose tissue and liver of male rats: a possible link to elevated triglycerides
... 2005). Leptin, a hormone expressed by the Lep gene mainly in adipocytes, controls food intake and energy expenditure (Zhang et ...of leptin are mediated through its receptor (LEPR), which is not only ...
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Leptin receptors
... in leptin-receptor ...the leptin receptor ...between leptin and Gln223Arg polymorphisms of LePr gene can in- crease the risk of the development of non-hodgkin lymphoma in obese patients ...
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Resistance to adenovirally induced hyperleptinemia in rats Comparison of ventromedial hypothalamic lesions and mutated leptin receptors
... plasma leptin values threefold above the control VMHL rats, neither body weight nor the weight of epididymal and retroperitoneal fat depots were ...to leptin in vivo, the direct in vitro lipopenic action of ...
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Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin releasing hormone
... endogenous leptin receptors and PC1 and PC2 has not been reported, we used a heterologous transfection system that we have described earlier (10, ...the leptin receptor (ObRb), together with PC1 ...
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Leptin and the leptin receptor : Molecular and genetic studies
... serum leptin concentration was observed between 16 and 28 weeks in subjects who were non-smokers but had a poor pregnancy ...that leptin is a necessary factor in placental development and therefore in ...
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Effect of Plasma-leptin on Cardiac Disorders with Type 2 Diabetes-patients
... recorded for 5 minutes), PL and sOb-R levels were logarithm-transformed (Log) to achieve normal distribution in the analysis. A non- repeated t test (continuous variables with normal distribution) and Chi square test ...
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Receptor mediated regional sympathetic nerve activation by leptin
... the leptin re- ceptor (7, ...after leptin, albeit ...mutated leptin receptors or a partial nonreceptor-mediated effect of leptin on sympathetic nerve traffic to ...of leptin is ...
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Review Article Role of leptin and its receptors in the pathogenesis of thyroid cancer
... Functional leptin receptors are expressed on diversed cancer cells derived from various solid tumors ...cells, leptin able to mediates its growth and proliferative action via binding to its specific ...
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A palatable hyperlipidic diet causes obesity and affects brain glucose metabolism in rats
... of leptin receptors (Ob-Rb and Ob-Ra) in the central nervous ...hypothalamus leptin receptors could induce leptin resistance in hyperli- pidic-fed ...mRNA leptin receptor ...
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Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G > A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia
... of leptin and leptin receptor genes in pediatric popula- ...of leptin and leptin receptor genes with overweight and the intensity of chemotherapy and/or ...both leptin and leptin ...
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NO ASSOCIATION OF THE LEPTIN (RS17151919) AND LEPTIN RECEPTOR (RS3790434) GENE POLYMORPHISMS WITH IRRITABLE BOWEL SYNDROME IN TURKISH POPULATION
... [27] Leptin, when bound to its soluble leptin receptor, decreases the phosphorylation of signal transducer and activator of transcription-3 (STAT-3) and blocks the regulatory effects of leptin on ...
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Neuroanatomy of body weight control: lessons learned from leptin
... deleting leptin receptors from distinct brain regions and neuronal subsets, researchers are beginning to identify the neuroanatom- ical substrates responsible for this ...of leptin receptors ...
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Short Term International Study For Teachers As A Form of Experiential Learning: A Case Study of American Educators in Turkey
... both leptin and LPS showed a marked increase in the gp91/p47 phox colocalization events while administration of SsnB (100 µg/ml) resulted in a significant decrease of the events (Figure ...
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Original Article Leptin induces partial epithelial-mesenchymal transition in a FAK-ERK dependent pathway in MCF10A mammary non-tumorigenic cells
... although leptin induces a partial redistribution of the epithelial marker E-cadherin at the plasma membrane, there is no decrease of E-cadherin expression, which may explain the collective cell migration phenotype ...
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Leptin promotes migration and invasion of breast cancer cells by stimulating IL-8 production in M2 macrophages
... 27]. Leptin receptor ObRb has been found to be expressed in macrophages ...[28]. Leptin induces macrophage recruitment to the tumor microenvironment by stimulating aromatase and estrogen receptor (ER) α in ...
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Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis
... that leptin, an adipocyte-secreted hormone belonging to the helical cytokine family, significantly influences immune and autoimmune ...of leptin effects protects SJL/J mice from proteolipid protein peptide ...
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Leptin inhibits 4 aminopyridine– and pentylenetetrazole induced seizures and AMPAR mediated synaptic transmission in rodents
... Neocortical seizure model. Four- to six-week-old male Sprague-Dawley rats were anesthetized with halothane (4%) and then placed on a stereotaxic frame (David Kopf Instruments). A burr hole was drilled over the left hemi- ...
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Phocid seal leptin : tertiary structure and hydrophobic receptor binding site preservation during distinct leptin gene evolution
... hormone leptin is a key signalling molecule in many pathways that control physiological ...Although leptin demonstrates structural conservation in mammals, there is evidence of positive selection in ...
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2018_Gung.pdf
... proliferation. Leptin therefore may mediate obesity-induced breast cancer progression through multiple mechanisms ...subtype. Leptin signaling may contribute to this link, as obesity has been shown to ...
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A leptin fragment mirrors the cognitive enhancing and neuroprotective actions of leptin
... of leptin into the hippocampus facilitates learning (Wayner et al, 2004), whereas hippocampal dendritic morphology, glutamate receptor trafficking and synaptic plasticity are significantly altered after ...
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