leucine-rich repeat protein
Extracellular Leucine-Rich Repeat Protein Let-4 is Required to Organize the Extracellular Matrix and Maintain Junctions in C. Elegans Epithelia
... Drosophila is a powerful model organism, and has therefore been a useful system to study the apical ECM. The apical ECM initially surrounding the Drosophila embryo is the eggshell, which functions to protect the egg from ...
231
LRT, a tendon specific leucine rich repeat protein, promotes muscle tendon targeting through its interaction with Robo
... LRT protein was detected at relatively late stages of embryonic development following muscle attachment to tendon cells. This suggests that it does not function primarily to guide muscles to their attachment ...
9
An Arabidopsis thaliana leucine rich repeat protein harbors an adenylyl cyclase catalytic center and affects responses to pathogens
... site-leucine-rich repeat (NBS-LRR) family, which are involved in disease resistance and are believed to bind to pathogen-associated proteins (McHale et ...host protein or a pathogen ...
38
A Toxoplasma gondii Leucine-Rich Repeat Protein Binds Phosphatase Type 1 Protein and Negatively Regulates Its Activity
... the protein level, antibodies raised against recom- binant TgLRR1 were used to detect native TgLRR1 in parasite ...predicted protein sizes ...the protein signal of TgLRR1 was found to be stron- ...
12
Original Article Leucine-rich repeat neuronal protein 4 (LRRN4) potentially functions in dilated cardiomyopathy
... like protein PI3K/Akt signaling pathway [22], stretch-acti- vated channel [23], ...that leucine-rich repeat protein played an important role in cardiac remodeling [10] and cardiac ...
9
The small leucine rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway
... Small leucine-rich repeat proteoglycan (SLRP) family proteins play important roles in a number of biological events. Here, we demonstrate that the SLRP family member Asporin (ASPN) plays a crucial ...
11
The CCR4 protein from Saccharomyces cerevisiae contains a leucine-rich repeat region which is required for its control of ADH2 gene expression.
... The CCR4 Protein From Saccharomyces cerevisiae Contains a Leucine-Rich Repeat Region Which Is Required for Its Control of ADH2 Gene Expression.. Thomas Malvar,* Rachel W.[r] ...
12
The Pathological and Biochemical Characterization of Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease
... While this list of compounds capable of inhibiting LRRK2 kinase activity been expanded over the few years since we published our study, it wasn’t until late 2010 that their utility had been shown in vivo (194). As ...
170
Functional analyses of a novel leucine rich repeat containing protein, Elfn1, in the mouse
... 1.3 Leucine-rich repeat proteins in nervous system development Studies have shown that there are a large number of LRR-containing proteins expressed in the central nervous system CNS, a [r] ...
235
Regulation of cell separation during organ abscission in Arabidopsis thaliana
... the leucine-rich repeat receptor- like kinase SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 (SERK1) acts as a negative regulator of ...GTPase-activating protein required for floral organ ...
117
The cytomegalovirus encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice
... expressing leucine rich repeat containing GPCR5 (Lgr5), a marker gene of intestinal epithelial stem ...β-catenin protein, and increased expression of Wnt target genes involved in the control ...
11
Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
... Only one mutation, the G2019S located in the activation loop of the kinase domain, clearly increases kinase activ- ity (reviewed in [57]), while other mutations do not con- vincingly do so [57]. Since blocking kinase ...
10
Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression
... Because p53 is one of the most important tumor sup- pressors, the physiological consequence of p53 phos- phorylation by LRRK2 related to cancer is a critical question. Our Western data show increase in p21 and cleaved ...
15
The extracellular leucine rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
... of protein sequences for which HMMpfam had predicted LRR motifs already (using the PFAM and SMART ...half repeat before the CT domain as one and did not include putative LRRs that overlapped with ...
24
A novel mutation in LRSAM1 causes axonal Charcot-Marie-Tooth disease with dominant inheritance
... N-terminal leucine-rich repeat domain, an ezrin- radixin-moezin domain, a coiled-coil region, a sterile alpha motif domain and a C-terminal C3HC4-type RING finger domain (Figure ...101 protein ...
7
Extracorporeal liver assist device to exchange albumin and remove endotoxin in acute liver failure: Results of a pivotal pre-clinical study
... NAPQI protein adducts causes mitochondrial oxidant stress and ultimately hepatocyte death ...box-1 protein (HMGB1), heat shock protein 70 and deoxyribonucleic acid (DNA) fragments ...nacht, ...
9
The fibronectin leucine rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis
... 10 leucine- rich repeats flanked by cysteine-rich regions, a type III fibronectin domain followed by the transmembrane segment and a short intracellular tail (Lacy et ...
12
Structural and Molecular Insights into Leucine Rich Repeat Receptor Kinases (LRR-RKs) in Plants.
... the protein and form flexibly extended branches 126 ...maintaining protein conformation and stability, executing cellular interactions, and protecting from protease degradation 127,128 ...the protein ...
158
Structure and developmental expression of mouse Garp, a gene encoding a new leucine rich repeat containing protein
... In! ,I, I)c,', Bioi, ~O 5~5 555 (t996) 545 Structure and developmental expression of mouse Garp, a gene encoding a new leucine rich repeat containing protein REGINE ROUBIN*, SANDRINE PIZETTE, VINCENT[.] ...
11
Lack of Evidence for Decreased Protein Stability in the 2397 (Met) Haplotype of the Leucine Rich Repeat Kinase 2 Protein Implicated in Parkinson’s Disease
... This study also investigated the effect of ROC and WD40 mutations on LRRK2 protein stability, and subsequent cell viability. As previously stated, the WD40 domain functions in vesicle trafficking, signal ...
11