Leucine-Rich Repeat Proteins
Transcriptional profile of Aedes aegypti Leucine-Rich Repeat Proteins in response to Zika and Chikungunya viruses
... Supplementary Materials: Table S1 : Female Aedes aegypti transcriptomic RNA-seq data show Leucine- Rich Repeat Proteins 7-days post infection or post injection between Key west and Orl[r] ...
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Transcriptional profile of Aedes aegypti Leucine-Rich Repeat Proteins in response to Zika and Chikungunya viruses
... two leucine-rich repeat (LRR) proteins, LRIM1 and APL1, have been shown to strongly affect ...LRR-containing proteins, AaeLRIM1 and AaeAPL1, not only affect regulated parasites in the ...
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Extracellular leucine rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C elegans
... eLRRon proteins in the apical ECM are in a good position to interact with cadherins or with transmembrane apical polarity proteins such as Crumbs, and could potentially influence junction maintenance ...
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Functional analyses of a novel leucine rich repeat containing protein, Elfn1, in the mouse
... 1.3 Leucine-rich repeat proteins in nervous system development Studies have shown that there are a large number of LRR-containing proteins expressed in the central nervous system CNS, a [r] ...
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Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?
... with proteins that regulate DA synthesis and uptake, such as tyrosine hydroxylase [26], the aromatic amino acid decarboxylase [27] and plasma membrane dopamine transporter ...
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The extracellular leucine rich repeat superfamily; a comparative survey and analysis of evolutionary relationships and expression patterns
... six proteins in another novel mam- mal-specific cluster, the Elron cluster, several of which show highly suggestive expression patterns in the devel- oping nervous ...fly proteins in this class that are ...
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Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression
... p53 proteins after incubation with LRRK2 WT or GS, but not with ...tant proteins to detect the p53 phosphorylation ...1–293 proteins after incubation with LRRK2, whereas it detected strong signal in ...
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The fibronectin leucine rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis
... known leucine-rich repeat cell-surface proteins failed to detect interactions between the Flrt paralogues and members of the Fgfr family (Sollner and Wright, ...transmembrane proteins, ...
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Original Article Leucine-rich repeat neuronal protein 4 (LRRN4) potentially functions in dilated cardiomyopathy
... LRR proteins have been discovered functioned not only in response to pathological stimuli but also in various typical signaling pathways in DCM ...LRR proteins are the focus of much ...that ...
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Point mutation in a leucine rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard Soulier syndrome
... Leucine-rich repeats are a conserved structural motif, of yet undefined significance, found in a group of proteins from different species. Among these are the four components of the human platelet ...
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A novel mutation in LRSAM1 causes axonal Charcot-Marie-Tooth disease with dominant inheritance
... N-terminal leucine-rich repeat domain, an ezrin- radixin-moezin domain, a coiled-coil region, a sterile alpha motif domain and a C-terminal C3HC4-type RING finger domain (Figure ...receptor ...
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Functional Characterisation of the Flax Rust AvrP/AvrP123 Avirulence Proteins
... into leucine-rich repeat (LRR) domain, lysin motif (LysM) domain, lectin domain, or epidermal growth factor (EGF)-like domain (Bohm et ...bind proteins or peptides, such as the Arabidopsis ...
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Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype
... Brain tissue punches and organs were collected to detect levels of BDNF (R&D Systems, MAB248), 5-HT1A (Genetex, GTX104703), CX3CR1 (Sigma-Aldrich, SAB3500204), and WAVE2 (Cell Signaling Technology, 3659), as ...
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Leucine-rich-repeat-containing variable lymphocyte receptors as modules to target plant-expressed proteins
... certain proteins, ...plant proteins, and to construct chimeric proteins with new specificities in which the endogenous interacting domains are replaced by those of ...
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A conserved gene family encodes transmembrane proteins with fibronectin, immunoglobulin and leucine-rich repeat domains (FIGLER)
... immunoglobulin leucine-rich repeat ...6–12 leucine-rich repeats (LRR), a C2 type Ig domain, a fibronectin type III domain, a hydrophobic transmembrane domain, and a cytoplasmic domain ...
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Structural and Molecular Insights into Leucine Rich Repeat Receptor Kinases (LRR-RKs) in Plants.
... conjugated proteins but also plays significant roles in various biological processes such as maintaining protein conformation and stability, executing cellular interactions, and protecting from protease ...
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The Pathological and Biochemical Characterization of Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease
... the leucine-rich repeat (LRR) region of LRRK2, Shin and colleagues discovered that this portion of the protein interacts with Rab5b ...Both proteins were detected in the soluble synaptosome ...
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CINNAMON'S ANTIBACTERIAL ACTIVITY ON THE BACTERIAL ISOLATES FROM URINARY TRACT INFECTIONS
... (Leucine-rich repeat kinase 2), This depends on the ethnic group; Therefore these susceptibility genes should be considered as important risk ...
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Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S Parkinson’s disease
... Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. While most of PD cases are idiopathic, monogenic forms of the disease are demon- strated in about 5–10% of patients [1]. Mutations in leu- ...
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Molecular mechanisms used by Staphylococcus aureus to access iron from human haemoglobin
... Recent advances have been made in understanding how the outer membrane receptors recognise and interact with host proteins. Haemoglobin receptors have been identified in a number of Gram-negative pathogenic and ...
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