lipogenic genes
Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor-driven transcription of hepatic lipogenic genes in vivo
... The liver X receptor (LXR) is a nuclear oxysterol receptor, which functions as a transcriptional regulator of genes in- volved in lipid metabolism (Repa et al., 2000). Active LXR regu- lates cholesterol ...
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Effects of the replacement of corn oil with linseed oil on fatty acid composition and the expression of lipogenic genes in broiler chickens
... ABSTRACT: The effect of dietary 18:2n-6/18:3n-3 ratio (by the replacement of corn oil with linseed oil) on n-3 polyunsaturated fatty acids (PUFA) enrichment in breast muscle of broiler chickens and the expression of ...
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Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation
... these genes is primarily caused by an alteration of ChREBP nuclear ...the genes encoding L-PK and FAS and demonstrate that ChREBP is a pivotal transcription factor responsible for coordinating the PUFA ...
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Effect of different dietary oil sources on the growth performance, blood characteristics, fatty acid profiles, and expression of lipogenic genes in the liver of broiler chickens
... ABSTRACT: The effect of different levels of corn oil (CO) and flaxseed oil (FO) on growth performance, blood characteristics, fatty acid composition, and expression of lipogenic genes in the liver of ...
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Aqueous extract of post fermented tea reverts the hepatic steatosis of hyperlipidemia rat by regulating the lipogenic genes expression and hepatic fatty acid composition
... of lipogenic genes and the up-regulation of genes involved in catabolism of free fatty acids, possibly by a feedback ...β-oxidation genes and down-regulation of de novo synthesis could be ...
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Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency
... examining 18S and 28S rRNA by agarose gel electropho- resis. The RNA was then treated with DNase I (Roche, IN, USA) and reverse-transcribed using SuperScript II (Invit- rogen, CA, USA) in a final volume of 120 lL. The ...
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Selective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone A
... Figure 3 Effects of LicA on (A) the LXR α -stimulated expression of lipogenic genes and (B) TG accumulation in mouse primary hepatocytes. (A) T0901317-induced expression of SREBP-1c, SCD1, FAS, and GPAT was ...
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Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets
... involved in fat hydrolysis (P < 0.05) (Fig. 1b) as well as FABP4 and CD36 (P < 0.05) (Fig. 1c) involved in fatty acid transport were significantly increased in piglets fed the L- BCAA diet compared with those fed ...
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Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells
... The results from 48 hour fatty acid analysis of FAO cells showed that at 48 hours the PL of cells treated with DPA contained both DPA and EPA. Therefore it was not clear if the results obtained in gene expression and ...
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Endogenous Lipogenic Regulators of Spore Balance in Aspergillus nidulans
... SREBP genes (basic helix-loop-helix leucine zipper transcription factors) that possess considerable selectivity difference in their target genes and bind to the sterol regulatory element (SRE) DNA motif in ...
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Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor
... metabolic genes, with particular focus on the details of the coactivator complex and a view toward modulating specific target gene ...of lipogenic genes, including SREBP-1c, fatty acid synthase ...
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Tribbles 1 regulates hepatic lipogenesis through posttranscriptional regulation of C/EBPα
... mice, suggesting that increased ALTs are a consequence of decreased Trib1 levels and not an artifact of the virus administra- tion. The observation that Trib1_LSKO mice have increased his- topathological findings ...
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Polyphenolic extract of lotus root (edible rhizome of Nelumbo nucifera) alleviates hepatic steatosis in obese diabetic db/db mice
... condensed tannins in the polyphenolic lotus root extract is illustrated in Figure 7. There are several studies reporting that proanthocyanidins possess various in vivo physiologi- cal properties, such as antioxidant, ...
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Comparisons of the iron deficient metabolic response in rats fed either an AIN-76 or AIN-93 based diet
... the lipogenic genes Acly and Fas were higher in the 76-PF group compared to the 93-PF group, though the expression of the lipogenic master transcriptional regulator Srebp1c remained largely ...group, ...
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Trib1 is a lipid and myocardial infarction–associated gene that regulates hepatic lipogenesis and VLDL production in mice
... Recent genome-wide association studies have identified a genetic locus at human chromosome 8q24 as having minor alleles associated with lower levels of plasma triglyceride (TG) and LDL cholesterol (LDL-C), higher lev- ...
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ChREBP regulates fructose induced glucose production independently of insulin signaling
... and lipogenic genes, plays a central role in this ...and lipogenic genes as well as glucose-6-phosphatase (G6pc) that was associated with the effects of fructose ...
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Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes
... of lipogenic genes and fasting triglycerides; 3) CAV-1 gene expression was significantly increased in mature adipocytes compared with SVC fraction from both visceral and subcutaneous adipose tissue (Figure ...
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Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway
... of lipogenic genes including SREBP1 and FASN were significantly increased in the livers of HFD-fed mice compared with the mice fed with normal diet ...the lipogenic genes such as SREBP1, FASN, ...
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E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis
... reveal that E2F1 plays an essential role in liver physiopathology through the regulation of glycolysis and lipogenesis. We demonstrate that E2F1 deficiency leads to a decrease in glycolysis and de novo synthesis of fatty ...
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Hepatic glucose sensing: does flux matter?
... In this issue of the JCI, Denechaud et al. report studies investigating the role of the liver X receptors (LXRs) LXRα and LXRβ in carbohydrate sensing by the liver (see the related article beginning on page 956). The ...
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