lncRNA NEAT1
LncRNA-NEAT1 from the competing endogenous RNA network promotes cardioprotective efficacy of mesenchymal stem cell-derived exosomes induced by macrophage migration inhibitory factor via the miR-142-3p/FOXO1 signaling pathway
... induced increase in miR-142-3p was not alleviated by exosome MIF derived from MSCs with silenced lncRNA- NEAT1 (Fig. 3b). A search of the bioinformatics data- base (LncBase) suggested the existence of a ...
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Original Article Up-regulated expression of lncRNA NEAT1 promotes progression of osteosarcoma by regulating the activity of Wnt/β-catenin pathway
... of lncRNA NEAT1 in OS, we determined the expression level of NEAT1 in 37 OS tissues and adjacent non- tumor tissues by qRT-PCR, and normalized to ...that NEAT1 expression was significantly ...
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<p>lncRNA NEAT1 Facilitates Cell Proliferation, Invasion and Migration by Regulating CBX7 and RTCB in Breast Cancer</p>
... the lncRNA NEAT1 exerts its effects in breast cancer, we fi rst deter- mined its cellular ...that NEAT1 is predominantly located in the cyto- plasm but can also be found in the nucleus (Figure ...by ...
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LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells
... The lncRNA Neat1 had significantly increased ex- pression when miR-124 was overexpressed in SC- NPCs, and significantly decreased expression when miR-124 was knocked down by miR-124 inhibitor ...and ...
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The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5
... NEAT1 siRNAs (si1: sense 5’-GACCGUGGUUUGUU ACUAUdTdT-3′, antisense 5′-AUAGUAACAAACCA CGGUCdTdT-3′; si2: sense 5′-GUUGGUCAUUCCUA AAUCUTT-3′, antisense 5′-AGAUUUAGGAAUGACC AACTT-3′), si-DDX5 (sense: ...
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LncRNA NEAT1 contributes to paclitaxel resistance of ovarian cancer cells by regulating ZEB1 expression via miR-194
... of NEAT1 and miR-194 on ZEB1 function, SKOV3/PTX and HeyA-8/PTX cells were transfected with si-ZEB1, si-ZEB1 + pcDNA-NEAT1, si-ZEB1 + anti-miR-194, or matched ...while NEAT1 overexpression or miR-194 ...
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Knockdown of lncRNA NEAT1 suppresses hypoxia-induced migration, invasion and glycolysis in anaplastic thyroid carcinoma cells through regulation of miR-206 and miR-599
... of NEAT1 knockdown on ATC cell migration, invasion, and glycolysis under ...the NEAT1/miR-206 axis on ATC progression under hypoxia will be performed in further ...the NEAT1/miR-599 axis- mediation ...
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<p>LncRNA NEAT1 Promotes Proliferation, Migration And Invasion Via Regulating miR-296-5p/CNN2 Axis In Hepatocellular Carcinoma Cells</p>
... study, NEAT1 was predicted and con fi rmed to be a sponge of miR-296-5p and negatively modulated miR- 296-5p expression in HCC ...among NEAT1, miR-296-5p and CNN2, and we demonstrated that NEAT1 ...
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<p>LncRNA NEAT1 Regulates 5-Fu Sensitivity, Apoptosis and Invasion in Colorectal Cancer Through the MiR-150-5p/CPSF4 Axis</p>
... One-month-old male BALB/c-nude mice (Laboratory ani- mal center of southern medical university, Guangzhou, China) were used in this study. All experiments were author- ized by the Animal Care Committee of Central ...
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Original Article Downregulation of lncRNA NEAT1 inhibits mouse mesangial cell proliferation, fibrosis, and inflammation but promotes apoptosis in diabetic nephropathy
... that lncRNA plays crucial roles in multiple biologic process- es (including regulation of gene expression, recruitment of chromatin modification, X chro- mosome inactivation, chromosome recombina- tion and protein ...
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<p>Long Noncoding RNA NEAT1 Promotes Cell Proliferation And Invasion And Suppresses Apoptosis In Hepatocellular Carcinoma By Regulating miRNA-22-3p/akt2 In Vitro And In Vivo</p>
... regulator, lncRNA NEAT1 participates in the regulation of various cancers, including breast cancer, 8 colorectal cancer 9 and gastric ...that NEAT1 is associated with tumorigenesis and metastasis 11 ...
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<p>Long Non-Coding RNA NEAT1 Promotes the Proliferation, Migration, and Metastasis of Human Breast-Cancer Cells by Inhibiting miR-146b-5p Expression</p>
... of lncRNA NEAT1 and microRNA (miR)-146b-5p in BC tissues and cell ...of lncRNA NEAT1 and miR-146b-5p on progression of BC ...between lncRNA NEAT1 and miR-146b-5p was examined by ...
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Long noncoding RNA NEAT1 promotes nasopharyngeal carcinoma progression through regulation of miR-124/NF-κB pathway
... (lncRNA) NEAT1 has been determined as an oncogenic gene in a variety of ...of NEAT1 in NPC and its underlying mechanism have not been well ...that NEAT1 was upregulated and miR-124 was ...
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Prognostic role of long noncoding RNA NEAT1 in various carcinomas: a meta-analysis
... High NEAT1 expression was associated with a poor prognosis and an increased risk of lymph node metastasis (LNM) in cancer ...of NEAT1 as a biomarker for cancer ...of lncRNA NEAT1 and overall ...
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Original Article Long non-coding RNA NEAT1 predicts elevated chronic obstructive pulmonary disease (COPD) susceptibility and acute exacerbation risk, and correlates with higher disease severity, inflammation, and lower miR-193a in COPD patients
... Apart from the in vivo or in vitro experiments that investigate the mechanism of lnc-NEAT1, some clinical practices have also been per- formed and disclose the dysregulation of lnc- NEAT1 in ...
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Iron Regulated SurfaceDeterminant (Isd) Proteins of Staphylococcus lugdunensis
... five. NEAT1, -3, -4, and -5 bind heme, while all motifs associate with ...hemoglobin. NEAT1 and NEAT5 extract heme, which is then transferred by NEAT1, NEAT3, and NEAT4 to the cell wall-anchored IsdC ...
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Knockdown of NEAT1 restrained the malignant progression of glioma stem cells by activating microRNA let-7e
... To investigate whether NEAT1 was associated with the RISC, we performed RNA immunoprecipitation. GSCs were lysed in complete RNA lysis buffer containing protease inhibitor and RNase inhibitor from an EZ- Magna RIP ...
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<p>Metformin Suppresses the Proliferation and Promotes the Apoptosis of Colon Cancer Cells Through Inhibiting the Expression of Long Noncoding RNA-UCA1</p>
... 4 LncRNA-UCA1 knockdown facilitates the anticancer effects of metformin against colon cancer cells in ...of lncRNA-UCA1 in the SW480 and SW620 cells in ...
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Enhanced expression of long non coding RNA NEAT1 is associated with the progression of gastric adenocarcinomas
... with NEAT1 shRNA or nonsense strand were detached with trypsin/ethylene diamine tetraacetic acid, washed once with DMEM containing 10 % fetal bovine serum (FBS), and re-suspended in DMEM containing 1 % FBS at 2 × ...
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A novel long non-coding RNA-KAT7 is low expressed in colorectal cancer and acts as a tumor suppressor
... that lncRNA FOXF1-AS1 is a possible cancer suppressor and its expression is decreased in gastric cancer tissues and lung cancer tis- ...that lncRNA-KAT7 was low expressed in CRC cancer tissues and cells and ...
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