Localized Scleroderma
A rare association of localized scleroderma type morphea, vitiligo, autoimmune hypothyroidism, pneumonitis, autoimmune thrombocytopenic purpura and central nervous system vasculitis Case report
... The localized scleroderma (LS) is distinguished from systemic sclerosis not only by the absence of vasospasm, structural vascular damage, and involvement of internal organs, but also by the distribution of ...
5
Interferon gamma inducible protein 10 as a potential biomarker in localized scleroderma
... Scleroderma, a connective tissue disease characterized by cutaneous sclerosis, is a broad term that encompasses both forms of the disease: systemic sclerosis (SSc) and localized scleroderma (LS), ...
8
Reliability of LoSCAT score for activity and tissue damage assessment in a large cohort of patients with Juvenile Localized Scleroderma
... and reliable outcome measures represented a limitation for clinicians over the years. Several assessment tools such as Computerized skin score (CSS) [4], infrared thermography (IRT) [5], laser doppler flowmeter [6], ...
5
Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) adapted for use in adult patients: report from an initial validation study
... Localized Scleroderma Cutaneous Assessment Tool (LoS- CAT) ...fied Localized Scleroderma Skin Severity Index (mLoSSI), which is designed to measure LoS activity, and the Local- ized ...
7
Sonographic evaluation of pediatric localized scleroderma: preliminary disease assessment measures
... As an initial step towards developing ultrasound as an assessment tool for localized scleroderma, our group has been working to standardize image acquisition and inter- pretation for these patients. ...
12
Assessment of esophageal involvement in systemic sclerosis and morphea (localized scleroderma) by clinical, endoscopic, manometric and pH metric features: a prospective comparative hospital based study
... as localized scleroderma, pre- dominantly involves the skin and occasionally involves subjacent ...of scleroderma and to compare the ...(localized scleroderma) ...
9
Developing comparative effectiveness studies for a rare, understudied pediatric disease: lessons learned from the CARRA juvenile localized scleroderma consensus treatment plan pilot study
... Background: We designed and initiated a pilot comparative effectiveness study for juvenile localized scleroderma (jLS), for which there is limited evidence on best therapy. We evaluated the process we used, ...
12
Clinical Characteristics and Prognosis of Morphea (Localized Scleroderma) in Adults: a Retrospective Study
... 7. Mertens JS, van den Reek JM, Kievit W, van de Kerkhof PC, Thurlings RM, Radstake TR, et al. Drug Survival and Predictors of Drug Survival for Methotrexate Treatment in a Retrospective Cohort of Adult Patients with ...
5
Pirfenidone gel in patients with localized scleroderma: a phase II study
... on localized scleroderma plaques may be related to its reported capacity to inhibit proinflammatory cytokines levels, as well as to activate interleukin 10 (IL-10) pro- ...
8
Increased serum levels of TGFβ1 in children with localized scleroderma
... 2. Zulian F, Athreya BH, Laxer R, Nelson AM, Feitosa de Oliveira SK, Punaro MG, Cuttica R, Higgins GC, Van Suijlekom-Smit LW, Moore TL, Lindsley C, Garcia-Consuegra J, Esteves Hilario MO, Lepore L, Silva CA, Machado C, ...
5
Scleroderma and dentistry: Two case reports
... (localized scleroderma) causes localized fi- brosis without systemic involvement and exists in five different forms but also can persist in “mixed form” where localized scleroderma of ...
6
Facial asymmetry: a case report of localized linear scleroderma patient with muscular strain and spasm
... PRS is a rare disorder characterized by slow and pro- gressive hemiatrophy of the soft tissue of the face, muscle, and bone. The etiologies of PRS are not well understood but are thought to include trauma, infection, and ...
7
Molecular characterisation of chromosomal instability in scleroderma
... Increased collagen accum ulation in derm al fibroblast cultures from patients with progressive system ic sclerosis (scleroderm a)... Followed by High-resolution PAGE.[r] ...
216
Endothelial cell-fibroblast interactions in scleroderma
... in scleroderma research in attempts to unravel pathogenic mechanisms and to evaluate experimental treatments (Jimenez and Christner, ...with scleroderma none represents a complete model and this limits ...
254
Skewed X-chromosome inactivation in scleroderma.
... scleroderma patients along with the parental origin of the inactive X chromosome in those patients with extremely skewed X-inactivation. In addition, the correlation between skewed X-inactivation and both maternal ...
12
Pharmacology and rationale for imatinib in the treatment of scleroderma
... of scleroderma showed significant anti-inflammatory and antifibrotic effects; however, several clinical, proof-of-concept trials have not yet confirmed these initially promising ...
8
Vascular involvement in systemic sclerosis (scleroderma)
... and scleroderma renal crisis are more commonly associated with ...sine scleroderma” is also recognized, in which there is internal organ involvement with occa- sional fibrosis of distal ...
21
Results From the Scleroderma Lung Study
... the Scleroderma Lung Study should be helpful to ...the Scleroderma Lung Study, the findings should provide us with addi- tional important information on the balance between the possible efficacy of ...
9
Study on Pulmonary Hypertension and Diastolic Dysfunction in Scleroderma
... This is to certify that this dissertation entitled “STUDY ON PULMONARY HYPERTENSION &DIASTOLIC DYSFUNCTION IN SCLERODERMA” submitted by Dr. BALAMURUGAN S. appearing for Part II M.D. Branch I General Medicine ...
97
The Pathogenesis of Esophageal Dysfunction in Scleroderma and Raynaud's Disease
... with scleroderma and Raynaud's disease. Six patients having scleroderma with normal peristalsis had an LES pressure significantly greater than that noted in 16 patients having scleroderma with ...
7