Long non-coding RNA NEAT1
Original Article Long non-coding RNA NEAT1 promotes metastasis via enhancing ZEB2 by sponging miR-662 in colorectal cancer
... that long non-coding RNA NEAT1 was dysregulated expression in some cancers and also closely related with malignant phenotype of lymphatic metastasis and TNM ...of NEAT1 still ...
9
Enhanced expression of long non coding RNA NEAT1 is associated with the progression of gastric adenocarcinomas
... Total RNA was isolated from tissues by using AxyPrepTM Blood Total RNA MiniPrep Kit (Axygen) according to the manufacturer ’ s ...amplifying NEAT1 and reference gen (ACTB) are the following: ...
6
Original Article Silencing of the long non-coding RNA NEAT1 suppresses ovarian cancer cell proliferation, migration and invasion
... Total RNA from cells was extracted using TRI- zol reagent (Invitrogen, USA) and 2 μg of RNA was used to reverse transcribed into cDNA (Fermentas, Hanover, MD, USA) following the manufacturer’s ...were: ...
10
Knockdown of Long Non Coding RNA NEAT1 Inhibits Proliferation and Invasion and Induces Apoptosis of Osteosarcoma by Inhibiting miR 194 Expression
... that NEAT1 contains a binding site of miR-194 ...between NEAT1 and miR-194, the luciferase reporter assay was ...whether NEAT1 could indeed regulate miR-194 expression, MG63 and U2OS cells were ...
9
<p>Long Non-Coding RNA-NEAT1 Promotes Cell Migration and Invasion via Regulating miR-124/NF-κB Pathway in Cervical Cancer</p>
... of RNA splicing, and translational/ post-translational ...lncRNA- NEAT1 decreased E-cadherin expression and increased the expression of N-cadherin and Vimentin in CC ...
12
<p>Long Non-Coding RNA NEAT1 Promotes the Proliferation, Migration, and Metastasis of Human Breast-Cancer Cells by Inhibiting miR-146b-5p Expression</p>
... lncRNA NEAT1. Co-transfection of NEAT1-WT and miR- 146b-5p mimics reduced the luciferase activity signi fi cantly, whereas co-transfection with NEAT1-Mut and miR-146b-5p mimics had a negligible effect ...
11
Original Article Long non-coding RNA NEAT1 promotes human clear cell kidney carcinoma progression through negative regulation of miR-129-5p
... to NEAT1 (Figure 3A; ...si- NEAT1 compared to si-NC group (Figure 3B; ...whether NEAT1 could pull do- wn miR-129-5p, we applied a pull down assay by a biotin-labeled specific NEAT1 ...between ...
9
Long non-coding RNA NEAT1/miR-338-3p axis impedes the progression of acute myeloid leukemia via regulating CREBRF
... Following the obtaining of proteins by Radio-Immuno- precipitation Assay (RIPA) lysis and extraction buffer (Thermo Fisher Scientific, Waltham, MA, USA), 40 μg proteins were split on 10% sodium dodecyl sulfate– ...
11
<p>Long Non-Coding RNA NEAT1 Serves as Sponge for miR-365a-3p to Promote Gastric Cancer Progression via Regulating ABCC4</p>
... It has been widely recognized that lncRNAs play crucial roles in regulating carcinogenesis including GC. 14,15 For instance, LINC00682 was found to decrease expression in GC cells, and its overexpression could upregulate ...
9
Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway
... found NEAT1 expression in NSCLC lung tissues was remarkably higher than that of in adjacent normal lung ...Specifically, NEAT1 expression was remarkably higher in larger tumors and at later stages of tumor ...
31
Original Article Clinical implication of long non-coding RNA NEAT1 expression in hepatocellular carcinoma patients
... several long non-coding RNAs (lncRNAs) and metastasis, drug resistance and other clinical outcome in several types of can- cers ...antisense RNA (HOTAIR), metastasis associated lung ...
8
<p>Long Non-Coding RNA NEAT1 Promoted Hepatocellular Carcinoma Cell Proliferation and Reduced Apoptosis Through the Regulation of Let-7b-IGF-1R Axis</p>
... Micro RNA (miRNA) is a kind of non-coding single- stranded small molecular RNA, which is involved in phy- siological processes such as growth, metabolism, and apoptosis in ...13,14 RNA ...
13
Dysregulation of the BRCA1/long non-coding RNA NEAT1 signaling axis contributes to breast tumorigenesis
... lncRNA NEAT1 expression is negatively regulated by BRCA1, potentially through the binding of BRCA1 to its cognate binding site upstream of the NEAT1 ...Moreover, NEAT1 is crucial for tumorigenicity ...
23
The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications
... this RNA to be polyadenylated ...only non-lethal, but also show no observable phenotype, including the cells’ ability to form nuclear paraspekles ...
88
Long non-coding RNA: a new player in cancer
... and NEAT1 were also found acting as scaffolds ...intergenic non-coding RNAs (lncRNAs) expressed in the cell types studied are reprodu- cibly associated with chromatin-modifying complexes (PRC2, ...
7
Long non-coding RNA UCA1 is a predictive biomarker of cancer
... Human urothelial carcinoma associated 1 (UCA1) is a long noncoding RNA that is putatively oncogenic in solid tumors. This meta-analysis investigated an association between UCA1 levels and survival times of ...
6
1 Long Non-Coding RNA Expression Levels Modulate
... Genes alternatively spliced via RI events in HeLa, and K562 reveal cell type specific functional 334. enrichment 335[r] ...
18
Cancer subtypes classification using long non-coding RNA
... Inter-tumor heterogeneity might explain divergent clinical evolution of cancers bearing similar pathological features. In the last decade, genomic has highly improved tumor subtypes classification through the ...
12
CRNDE: an oncogenic long non-coding RNA in cancers
... accelerated non-small-cell lung cancer (NSCLC) progression by sponging miR-338-3p [25] and enhanced HCC carcinogenesis by spong- ing miR-203, miR-384 or miR-217, thereby mediating BCAT1, NF-κB, p-AKT and MAPK1 ...
10
Expressions of Long Non Coding RNAs in Carcinogenesis of Cervix: A Review
... Metastasis-associated lung adenocarcinoma transcript 1(MALAT1) is a large, infrequently spliced 7.5 kb in length lncRNA located in chr11q13. MALAT1 was first identified by its link in non-small cell lung cancer ...
16