Long Noncoding
The multidimensional mechanisms of long noncoding RNA function
... lncRNAs as modulators of proteins and enzyme cofactors In most of the known examples, the detailed mecha- nisms by which lncRNAs enhance or inhibit the activity of proteins is not completely understood, but are prob- ...
13
Expression profiles and initial confirmation of long noncoding RNAs in Chinese patients with pulmonary adenocarcinoma
... expressed long noncoding RNAs (lncRNAs) in pulmonary adenocarcinoma tissue and adjacent noncancerous tissue from Chinese patients using lncRNA expression microarray and preliminary ...
10
Insights into long noncoding RNAs of naked mole rat ( Heterocephalus glaber ) and their potential association with cancer resistance
... Long noncoding RNAs (lncRNAs) are operationally defined as RNA transcripts longer than 200 bp that do not appear to have coding potential [10]. Recent stud- ies indicated that lncRNAs have become new ...
10
Long Noncoding RNA: Recent Updates in Atherosclerosis
... a long time, gene regulatory network has been mainly focusing on protein coding genes ...these noncoding transcripts, which are lowly- expressed, unstable and poorly conserved, play a significant role in ...
13
<p>Long Noncoding RNAs in Diffuse Large B-Cell Lymphoma: Current Advances and Perspectives</p>
... of noncoding RNAs (ncRNAs) in recent decades has revealed new prospects for tumor ...including long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs, are RNA transcripts of variable ...
9
Decoding Noncoding RNAs: Role of MicroRNAs and Long Noncoding RNAs in Ocular Neovascularization
... lncRNAs: long noncoding RNAs; ncRNAs: noncoding RNAs; tRNAs: transfer RNAs; pri-miRNAs: primary miRNAs; Pol II: RNA polymerase II; pre-miRNAs: precursor miRNAs; DGCR8: DiGeorge syndrome chromosomal ...
13
Multiplicity in Long Noncoding RNA in Living Cells
... inactivation. Long noncoding Xist RNA-chromatin associations are essential intermolecular interactions in the process of X chromosome ...involved long noncoding RNAs of three species: 255 ...
6
Long noncoding RNAs in renal diseases
... LncRNA: Long noncoding RNA; LUST: LUCA-15- specific transcript; MALAT-1: Metastasis-associated in lung adenocarcinoma transcript-1; Mdm2: Mouse double minute 2 homolog; MIAT: Myocardial infarction ...
9
Prognostic significance of the long noncoding RNAs in nasopharyngeal carcinoma: a systematic review and meta-analysis
... Background and objective: Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy. Despite recent advances in treatment, the prognosis, particularly for those at the advanced stages, remains poor. Moreover, ...
17
Functions and mechanisms of long noncoding RNAs in lung cancer
... diagnosis. Long noncoding RNAs (lncRNAs) are emerging as an important set of molecules because of their roles in various key pathophysiological pathways, including cell growth, apoptosis, and ...
14
The Long Noncoding RNA HEAL Regulates HIV 1 Replication through Epigenetic Regulation of the HIV 1 Promoter
... ABSTRACT A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying and eradicating persistent reservoirs of replication-competent provirus. Long noncoding RNAs (lncRNAs, ⬎ 200 ...
18
Long noncoding RNAs and neuroblastoma
... years long noncoding RNAs (lncRNAs) have become the cutting edge of cancer research with inroads made in understanding their roles in multiple cancer types, including prostate and breast ...
11
Landscape of tumor suppressor long noncoding RNAs in breast cancer
... In our previous study, the oncogenic lncRNA land- scape was identified and validated in breast cancer [10]. Moreover, we also identified an lncRNA, linc00152, which functions as a tumor propellant in breast cancer and ...
18
Investigating long noncoding RNAs using animal models
... The molecular mechanisms for most lncRNAs remain large- ly unknown. They can bind to DNA, RNA, or proteins, and many techniques have been developed to assay these interactions (Fig- ure 2A). Techniques exploring ...
10
Long noncoding RNA expression profiles in sub lethal heat treated hepatoma carcinoma cells
... Long noncoding RNA (lncRNA) is generally defined as a transcript larger than 200 nucleotides that lacks protein-coding functions. Recently, lncRNAs have been shown to have critical regulatory roles in ...
14
Long noncoding RNA dysregulation in ischemic heart failure
... Technologies). Long noncoding RNA expression profiles were measured using the disease-related human lncRNA Profiler (SBI, Sys- tem Biosciences) (Additional file 1: Table ...
14
Role of Long Noncoding RNAs in Diabetic Complications
... Multiple studies have previously been carried out examining specific genetic abnormalities as causative factors for the development of chronic diabetic complications. However, such studies have never been able to provide ...
172
The functions of long noncoding RNAs in development and stem cells
... Hox genes encode TFs that orchestrate the embryo body plan and contribute to several adult cell fate specification processes (Barber and Rastegar, 2010). In addition to containing protein-coding and miRNA genes, these ...
13
Expression profiles of long noncoding RNAs in lung adenocarcinoma
... Microarray of lncRNAs was performed by Beijing CapitalBio Technology Co., Ltd (Beijing, People’s Republic of China). lncRNAs from all canonical databases, NCBI Refseq, UCSC Known Gene, NRED, and RNAdb, were covered with ...
8
Long Noncoding RNAs: Past, Present, and Future
... the long erbAa isoform (Lazar et ...the long erbAa isoform without affecting its transcription or stability, and the antisense RNA has been implicated by both in vivo and in vitro experiments to repress ...
19