Long Noncoding Rna
Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer
... exosomal long noncoding RNA (lncRNA), termed lymph node metastasis-associated transcript 2 (LNMAT2), that stimulated human lymphatic endothelial cell (HLEC) tube formation and migration in vitro and ...
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Multiplicity in Long Noncoding RNA in Living Cells
... short-lived long non-coding RNAs as surrogate indicators for chemical ...and long noncoding RNAs ...types. Long noncoding RNA s are an important class of pervasive ...
6
A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer
... Firstly, RT-PCR detection in a larger size of tissues verified the significant down-regulation of lncRNA MDC1-AS and the reduction of MDC1-AS expression was also observed in bladder cancer cells EJ and T24, suggesting ...
10
Prognostic role of long noncoding RNA NEAT1 in various carcinomas: a meta-analysis
... Abstract: A number of studies have revealed that nuclear paraspeckle assembly transcript 1 (NEAT1), a long noncoding RNA (lncRNA), was aberrantly regulated in various cancers. High NEAT1 expression ...
8
JAK2 binding long noncoding RNA promotes breast cancer brain metastasis
... a long noncoding RNA (lncRNA) that we have named lncRNA associated with BCBM (Lnc-BM) is prognostic of the progression of brain metastasis in breast cancer ...
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Long noncoding RNA dysregulation in ischemic heart failure
... Total RNA from tissues was extracted using TRIzol (Life Technologies, Thermo Fisher Scientific ...Technologies). Long noncoding RNA expression profiles were measured using the disease-related ...
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Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia
... The evolutionarily conserved imprinted H19, together with its coregulated Igf2, plays an important role in embryo development and growth control and has been associated with human genetic disorders. H19 is highly ...
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Colorectal neoplasia differentially expressed: a long noncoding RNA with an imperative role in cancer
... a long noncoding RNA (lncRNA), has attracted increasing attention in recent years and has been documented to be at abnormally high expression in various types of cancer, such as colorectal cancer, ...
9
Induction of long noncoding RNA MALAT1 in hypoxic mice
... One of the most amazing outcomes of the high-throughput sequencing era is the discovery that approximately 75% of the genome is transcribed and that there might be approximately as many noncoding (nc) RNAs as ...
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Computational approaches to functionally annotate long noncoding RNA (lncRNA)
... Noncoding RNA (ncRNA) will not usually directly code for protein and were considered as junk regions in the DNA with little to no functional ...are long noncoding RNA (lncRNA), which ...
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The multidimensional mechanisms of long noncoding RNA function
... lncRNAs as modulators of proteins and enzyme cofactors In most of the known examples, the detailed mecha- nisms by which lncRNAs enhance or inhibit the activity of proteins is not completely understood, but are prob- ...
13
Original Article Long noncoding RNA GHET1 promotes the development of bladder cancer
... other noncoding transcripts less than 200 nucleotides (nt) but also a large class of long (> 200 nt) ncRNAs (lncRNAs), which have emerged as a new layer of cell biology [6, ...of RNA regulation in ...
10
ZFAS1: a long noncoding RNA associated with ribosomes in breast cancer cells
... This manuscript demonstrates a novel role for a long noncoding RNa (lncRNA) called ZFAS1. The authors es- tablish the validity of the previously made claim that ZFAS1 is, in fact, a lncRNA, ie. there ...
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Long Noncoding RNA: Recent Updates in Atherosclerosis
... Cellular lipid mechanism especially in foam cells is an important issue in atherosclerosis progress. Hu et al. find that lncRNA is a novel regulator in cholesterol metabolism and inflammation. Through microarray ...
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A long noncoding RNA mediates both activation and repression of immune response genes
... An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving signal-dependent activation of transcription factors, transcriptional ...
5
A long noncoding RNA positively regulates CD56 in human natural killer cells
... Human NK cell populations from different tissues differ in phenotype and function [37]. However, the mechanisms behind such differences are not yet well understood. In addition, current knowledge of the molecular ...
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The long noncoding RNA Tug1 connects metabolic changes with kidney disease in podocytes
... functionally annotated in the Long Non- coding RNA Database (3). lncRNAs have several modes of action but are generally considered important transcriptional reg- ulators. Enhancer RNAs are considered a ...
5
Long noncoding RNA mediated maintenance of DNA methylation and transcriptional gene silencing
... A multilayered pathway, comprising different repressive histone modifications such as H3K119ub1, H3K27me3 and H3K9me3 (Lewis et al., 2004; Umlauf et al., 2004; Pandey et al., 2008; Terranova et al., 2008), has been ...
12
Upregulation of long noncoding RNA MIAT in aggressive form of chronic lymphocytic leukemias
... several lncRNAs have been shown to function as an oncogene or tumor suppressor [reviewed in ref.4]. MIAT/ RNCR2, originally discovered as a candidate gene for myocardial infarction [5], is a lncRNA abundantly expressed ...
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Assessing recent selection and functionality at long noncoding RNA loci in the mouse genome
... Another caveat is that there is a potential problem of alignment reliability especially for noncoding regions. Orthologous sequences are often inferred across organisms by alignment of two or more sequences and ...
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