Lrp5/6
Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin
... in Lrp5/6 dCKO cerebellum are large in size and therefore very likely to be Purkinje ...in Lrp5/6 dCKO ...in Lrp5/6 dCKO mice ...in Lrp5/6 dCKO ...
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Cyclized Oligopeptide Targeting LRP5/6 DKK1 Interaction Reduces the Growth of Tumor Burden in a Multiple Myeloma Mouse Model
... Fig. 2. Luciferase reporter activity of cells treated with cyclized oligopeptide and ProteOn XPR36 analysis. MC3T3-E1-S-Top cells were treated with Wn- t3a, DKK1, sclerostin, and oligopeptide. (A) This graph shows the ...
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TGF-β in fibrosis by acting as a conductor for contractile properties of myofibroblasts
... in the nuclear and cytosolic levels of β-catenin (Fig. 2). In the “on” state, canonical WNT ligands interact with both the canonical WNT receptor frizzled (FZL) and the related protein 5/6 LDL receptor ...
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Developmental vascular regression is regulated by a Wnt/β catenin, MYC and CDKN1A pathway that controls cell proliferation and cell death
... in Lrp5/6 CKO animals, the distribution of EdU labeling was distinct ...when Lrp5 and Lrp6 were deleted from ...that Lrp5 and Lrp6 conditional deletion resulted in lower levels of VEC ...
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The Wnt co receptors Lrp5 and Lrp6 are essential for gastrulation in mice
... between Lrp5/6- and mesd-deficient embryos compared with Wnt3 mutants ...of Lrp5/6 double mutants and mesd mutants suggests that the AVE is, in fact, sufficient to induce anterior ...
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Developments in the scientific understanding of osteoporosis
... co-receptor LRP5/6 that stabilizes cytoplasmic β-catenin protein, which in turn translocates to the nucleus and activates the transcription of target genes via transcription factors including lymphoid ...
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Deletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37
... including LRP5, LRP6, β-catenin, and NUP37 were presented in Additional file 1: Figure S4 and ...of LRP5 with three distinct siRNAs (siLRP5–1#, siLRP5–2#, and siLRP5–3#) all significantly inhibited the ...
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A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene and bone mineral density in Japanese male workers
... Alcohol intake was not an independent determinant of BMD after adjustment for age, BMI, LRP5 A1330V polymorphism, past history of exercise, current exercise, and smoking. The effect of alcohol on BMD remains ...
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LDL receptor related proteins 5 and 6 in Wnt/β catenin signaling: Arrows point the way
... of Lrp5/Lrp6 ligands/antagonists are only found in vertebrates, the high similarity between the entire Arrow and Lrp5/Lrp6 extracellular domains implies that other evolutionarily conserved ligands may yet ...
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FOXO1 orchestrates the bone suppressing function of gut derived serotonin
... linking LRP5 to suppres- sion of serotonin, Fort et ...mass Lrp5 mutation ...that Lrp5 is a potent regulator of serotonin synthesis and that gut-derived serotonin suppresses bone ...
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Peröbner, Iris (2012): Der Wnt/β-Catenin-Signalweg in humanen mesenchymalen Stammzellen: molekulare Funktion der Wnt-Korezeptoren LRP5 und LRP6. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... Die Isolierung von Total-RNA aus eukaryotischen Zellen erfolgte mit dem Rneasy Mini Kit der Fa. Qiagen aus 6-Kavitäten-Zellkulturplatten. Dessen Prinzip basiert auf der Bindung der RNA an eine Silika-Gel-Membran ...
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Low density lipoprotein receptor–related protein 5 governs Wnt mediated osteoarthritic cartilage destruction
... of LRP5 was determined by labeling with an anti-LRP5 antibody and an Alexa 555–conjugated secondary anti- body ...of 6 μm and subjected to Alcian blue and immunohistochemical stain- ...of ...
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JAM3 maintains leukemia initiating cell self renewal through LRP5/AKT/β catenin/CCND1 signaling
... of LRP5 in THP-1 cells led to a marked downregulation of PDK1/AKT/β-catenin/CCND1 signaling, which could efficiently reverse the enhanced signaling resulting from the JAM3 overexpression (Supplemental Figure ...to ...
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Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines
... The expression of ER-α, ER-β and Bcl-2 proteins was detected by Western blot. MC3T3-E1 cells and MG-63 cells were treated with dioscin (0.25 μg/ml, 0.5 μg/ml and 1.0 μg/ml) or lovastatin (0.04 μM) for 72 h or 24 h and ...
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Association of LRP5 genotypes with osteoporosis in Tunisian post menopausal women
... women, LRP5 poly- morphisms frequencies were similar with previous stud- ies reported in women with Caucasian background [22,31,32], but different from those observed in Asian population ...
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How genomics has informed our understanding of the pathogenesis of osteoporosis
... (COL1A1), LRP5, TGF-β (TGFB1), interleukin-6 (IL6), osteoprotegerin or OPG (TNFRSF11b) and receptor activator of nuclear factor κB ligand or RANKL ...
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Mutations in known monogenic high bone mass loci only explain a small proportion of high bone mass cases
... missense LRP5 HBM mutations ...missense LRP5 mutations ...with LRP5 HBM ( prevalence 5/100,000) displayed a variable phenotype of skeletal dysplasia with increased trabecular BMD and cortical ...
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Vol 6, No 6 (2020)
... Hence, to contribute to the marketing literature and enterprise management, this study aimed to evaluate the quality of service in a fitness center through IPA by [r] ...
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Vol 6, No 6 (2020)
... of 6-week sprint training on speed and agility in football players was examined, they found that speed, agility, and maximal speed were analyzed and found that the training program affected ...
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Vol 6, No 6 (2020)
... Purpose: This study attempted to determine if implementing external focus attention ques (EFAQ) improved standing long jump (SLJ) performance when compared to implementing [r] ...
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