Lymphocyte function-associated antigen 1
Polymorphism of lymphocyte function associated antigen 1 demonstrated by a lupus patient's alloantiserum
... We have found a human serum, E27, obtained from a multiply transfused patient with systemic lupus erythematosus, which immunoprecipitates the lymphocyte function associated antigen-1 ...
9
Transfection of cells from patients with leukocyte adhesion deficiency with an integrin beta subunit (CD18) restores lymphocyte function associated antigen 1 expression and function
... Leukocyte adhesion deficiency (LAD) is an inherited immunodeficiency disease that is characterized by the deficient expression of the leukocyte adhesion glycoproteins lymphocyte function-associated ...
9
Mechanisms of drug induced lupus II T cells overexpressing lymphocyte function associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice
... with lymphocyte function- associated antigen 1 (LFA-1) (CD11a/CD18) overexpression, and concentrations of anti–CD11a insufficient to affect antigen reactivity will ...
7
A monoclonal antibody against lymphocyte function associated antigen 1 decreases HIV 1 replication by inducing the secretion of an antiviral soluble factor
... To determine whether LFA-1 MAb could bind to HIV-1, a virus capture assay was performed similar to what has pre- viously been described [21-23]. Briefly, ninety-six well plates (Nunc) were coated with ...
10
Abnormal cytolytic activity of lymphocyte function associated antigen 1 deficient human cytolytic T lymphocyte clones
... unchanged with prolonged culture, and identical on 14 different CTL clones. The function of the LFA-1 molecule was addressed using the LFA-1-deficient CTL clones and LFA-1- deficient lymphoid ...
6
Original Article Cytotoxic T lymphocyte-associated antigen-4 gene polymorphisms and biliary atresia susceptibility in Chinese children
... inhibitory function of CTLA4 and contributes to autoimmune diseases such as Grave’s disease (GD), type 1 diabetes, PBC and systemic lupus erythematous disease [24, 28, 29, ...
6
Ostermann, Georg (2002): Identification of junctional adhesion molecule (JAM)-1 as a novel immunoglobulin superfamily ligand for lymphocyte function-associated antigen (LFA)-1. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... The transmembrane constituents of TJs, all four membrane-spanning molecules, are the claudin proteins (Heiskala et al., 2001) and occludin (Furuse et al., 1993). They co-polymerize to heteropolymer TJ strands forming a ...
166
Induction of Immune Tolerance in Asthmatic Mice by Vaccination with DNA Encoding an Allergen–Cytotoxic T Lymphocyte-Associated Antigen 4 Combination
... Recently, the induction of regulatory T (Treg) cells has attracted much attention in terms of SIT (3, 11, 20). Treg cells constitutively express the interleukin-2 (IL-2) receptor chain (CD25) at high levels, and the ...
8
ARHGEF1 deficiency reveals Gα13 associated GPCRs are critical regulators of human lymphocyte function
... Primary antibody deficiencies (PADs) include a broad spectrum of disorders that range from the absence of B lymphocytes and serum Ig to normal serum Ig isotypes and concentrations, but aberrant anti- body responses ...
5
Association of Single Nucleotide Polymorphisms in Cytotoxic T-Lymphocyte Antigen 4 and Susceptibility to Autoimmune Type 1 Diabetes in Tunisians
... effector function, in part by inhibiting Th1 (interleukin 2 [IL-2] and gamma interferon [IFN- ␥ ]) cytokine production and IL-2 receptor ␣ -chain (p55; Tac) expression by engaging anti- gen-presenting cell ...
5
Review Article Association between cytotoxic T lymphocyte-associated antigen 4 polymorphism and type 2 diabetes susceptibility: a meta-analysis
... Type 2 diabetes (T2D) characterized by defi- cient insulin secretion and insulin resistance is a complex endocrine disease that affects the function of various organs of the body [1]. T2D has become one of ...
9
Effect of transfer factor on lymphocyte function in anergic patients
... Before transfer factor, none of the patients had delayed skin responses to any of the natural antigens studied. Their lymphocytes did not produce MIF after exposure to antigens in vitro and only one patient showed ...
12
L-CBM signaling in lymphocyte development and function
... (Figure 4). Although the protease activity is required for optimal activation of NF- κ B following TCR ligation, the MALT1-dependent BCL10 cleavage is not required for activation of NF- κ B and JNK. Instead, it is ...
12
Definition of Sequence Requirements for Latency-Associated Nuclear Antigen 1 Binding to Kaposi's Sarcoma-Associated Herpesvirus DNA
... did not exert severe effects on binding. These results are in- triguing, since several lines of evidence suggest similarities between the EBNA1 and LANA1 DNA-binding domains. First, there is predicted structural ...
6
The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical Relevance
... type 1 (HSV-1) is responsible for the downregulation of MHC class I surface expression in human fibroblasts, which is accompanied by a lack of CTL ...TAP function represents the basis for the ...
10
Interaction of the lymphocyte-derived Epstein-Barr virus nuclear antigen EBNA-1 with its DNA-binding sites.
... DNA filter binding assays and DNase I footprinting experiments showed that the intact Raji EBNA-1 protein recognized the two binding site loci in oriP and the BamHI-Q locus and no other [r] ...
10
ANTIBODY-DEPENDENT LYMPHOCYTE KILLER FUNCTION AND AGE
... “Cr release by effector lymphocytes against HL-A antibody-coated allogeneic lymphocyte tar-. gets according to age[r] ...
8
Cytotoxic T lymphocyte antigen 4 and immune checkpoint blockade
... infections associated with the use of high-dose cor- ticosteroids for irAEs, and these must be considered when patients present with new or worsening symptoms ...
8
Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma
... Approaches aimed at enhancement of the tumor specific response have provided proof for the rationale of immunotherapy in cancer, both in animal models and in humans. However, while many immunotherapeutic strategies ...
12
Structure and Function Relationships between ATPase Family, AAA Domain Containing Protein 5, Proliferating Cell Nuclear Antigen, and USP1-Associated Factor 1
... Figure 16. Representative purification of tagged protein and subsequent tag cleavage by TEV protease. UAF1_SLD was expressed in e. coli as a MBP-fusion protein. A) SDS- PAGE analysis of the cell lysate and soluble ...
98