lysosomal associated membrane protein
Original Article Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas
... the lysosomal marker LAMP-1 (lysosomal-associated membrane protein-1) was investigated by immunohistochemistry in 112 formalin fixed paraffin embedded astrocytomas and compared with ...
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Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx
... conserved, membrane-proximal ...The lysosomal polypeptide transporter TAPL (ABCB9) has recently been identified as a specific binding partner of LAMP-1 and LAMP-2 ...possible protein binding site ...
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Astemizole Inhibits mTOR Signaling and Angiogenesis by Blocking Cholesterol Trafficking
... and lysosomal-associated membrane protein 1 (LAMP1, sc-20011) and SRE-binding proteins (SREBP-1, sc-8984) were purchased from Santa Cruz ...4E-binding protein 1 (4EBP1, 9452S), ...
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Serum Resistance-Associated Protein Blocks Lysosomal Targeting of Trypanosome Lytic Factor in Trypanosoma brucei
... resident lysosomal pro- teins through the flagellar pocket prior to localization to the lysosome ...in protein sorting and ...of membrane fusion and vesicle ...
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β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes
... Analysis of the Expression and Localization of LAMP-1 and CD63—To visualize the cellular distribution of LAMP-1 and CD63 cells by immunofluorescence microscopy, cells were fixed and permeabilized as described previously ...
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Coupling of lysosomal and mitochondrial membrane permeabilization in trypanolysis by APOL1
... both lysosomal and mitochondrial membrane permeabilization (LMP and ...is associated with the kinesin TbKIFC1, of which both the motor and vesicular trafficking VHS domains are required for MMP, but ...
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Original Article Lysosomal integral membrane protein Sidt2 plays a vital role in insulin secretion
... vesicle-associated membrane pro- tein (VAMP) which is associated with the vesicle (a v-SNARE), synaptosomal-associated protein of 25 kDa (SNAP-25) and syntaxin which are ...
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Lang, Christina (2016): Transmembrane protein 106B, a risk factor in frontotemporal lobar degeneration, is a lysosomal type II transmembrane protein and affects autophagy. Dissertation, LMU München: Medizinische Fakultät
... in lysosomal function ...in lysosomal function and organization ...of lysosomal biogenesis, by a two-fold increase in GRN mRNA ...lysosome-associated membrane protein 1 (LAMP1) ...
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Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture
... are membrane-bound organelles that are found in the cytoplasm of most cells and contain various hydrolytic enzymes that are usually active at an acidic pH (⬍5) ...Lysosome- associated membrane ...
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Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury
... (lysosomal associated membrane protein1), phosphor- p44/43MPK, and ...expression, lysosomal activation, p75NGFR, and Ki67 ...WD, lysosomal proteosomal protein are activated in ...
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Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation
... to lysosomal/phagolysosomal membrane permeabilization (LMP), an upstream event programing susceptibility to apoptosis, and to apoptosis execution via a mitochondrial pathway, through dis- tinct ...
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High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission
... About 10% of the global population currently suffers from diabetes. Diabetes is a major risk factor for many late-onset diseases that include cardiovascular diseases, neuronal diseases and cancer (1-3). In diabetic ...
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A vaccinia virus core protein, p39, is membrane associated.
... the membrane association of ...integral membrane protein or is merely peripherally associated with membranes—for instance, via protein-protein interactions—the gene coding for ...
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Hantavirus Nucleocapsid Protein Is Expressed as a Membrane-Associated Protein in the Perinuclear Region
... a membrane-associated form of NBCCV could be utilized in the assembly of the RNP and how the RNP is targeted to the cell ...plasma membrane. Recent findings have shown that actin and ...
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Topology of the Membrane-Associated Hepatitis C Virus Protein NS4B
... nonstructural protein NS4B, which has been suggested to be a part of the replication ...this protein by using recombinant HCV NS4B constructs. The protein localized to the endoplasmic reticulum (ER), ...
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Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice
... toxicity associated with its ...modulate protein aggre- gation and the course of the ALS in SOD1G93A mice, suggesting that VAPB does not play a significant role in ALS patients that do not have VAPB ...
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Characterization of glycosylated Gag expressed by a neurovirulent murine leukemia virus: identification of differences in processing in vitro and in vivo.
... cell surface and secreted species expressed by MuLV-infected cells. For instance, Ledbetter et al. (23) found two glycosylated Gag species of 85 and 95 kDa expressed at the cell surface, while Pillemer et al. (33) found ...
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Function and membrane targeting of the multidrug resistance associated protein 2
... Analysis of expression of cMOAT MRP2, MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene MRPl, in human cancer cell lines.. Expression of human MRP6, a [r] ...
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The lysosomal protein cathepsin L is a progranulin protease
... (M6PR) pathway independent of SORT1 [13, 14]. In the brain, PGRN is mainly expressed in neurons and acti- vated microglia, and has been reported to have neuro- trophic and neuroprotective functions, maintaining neuronal ...
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Characterization of Two Putative Protein Translocation Components in the Apicoplast of Plasmodium falciparum
... FIG. 1. PfTic22 is a predicted apicoplast protein. (A) PfTic22 has a predicted bipartite leader consisting of a signal peptide (SP; yellow) and transit peptide (TP; orange) and a Tic22 homology domain (blue). The ...
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