Lysosomal membrane
Lysosomal Membrane Permeabilization is an Early Event in Sigma-2 Receptor Ligand Mediated Cell Death in Pancreatic Cancer
... cell membrane components in Bxpc3 and Aspc1 pancreatic cancer cells and accumulate in ...protective lysosomal membrane glycoprotein, LAMP1, with shRNA greatly reduced the viability of cells following ...
11
Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation
... in lysosomal membrane permeabiliza- ...of lysosomal proteases into the cytoplasm (20). However, lysosomal integrity could theoretically be compromised earlier to a more modest extent, allowing ...
13
Pneumolysin Activates Macrophage Lysosomal Membrane Permeabilization and Executes Apoptosis by Distinct Mechanisms without Membrane Pore Formation
... of lysosomal acidification (LLA) by flow cytometry (n ⫽ ...of lysosomal acidification (LLA) (C) and lysosomal membrane permeabilization, as characterized by cathepsin B (Cat B) translocation ...
13
High glucose–induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission
... We showed that plasma membrane TRPM2 channels responded to oxidative stress to generate Ca2+ signals, which induced lysosomal membrane permeabilisation leading to the mobilisation of lys[r] ...
39
Localization of the AP-3 adaptor complex defines a novel endosomal exit site for lysosomal membrane proteins
... in lysosomal membrane protein traffic from tubular sorting endosomes is in agreement with pre- vious immuno-EM data in PC12 and A431 cells (Dell’An- gelica et ...the membrane network within 500 nm of ...
12
β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes
... In this study, the amyloidogenic protein  2 m, the causative agent of dialysis-related amyloidosis (32), was used to investi- gate the cellular effects of fragmented amyloid fibrils. Despite inhibiting the cellular ...
16
Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization
... Monanchocidin A (MonA) is a novel alkaloid recently isolated from the marine sponge Monanchora pulchra. The compound reveals cytotoxic activity in genitourinary cancers including cisplatin-sensitive and -resistant germ ...
14
Vanadium induces liver toxicity through reductive activation by glutathione and mitochondrial dysfunction
... Hepatocyte lysosomal membrane stability was deter- mined from the redistribution of the fluorescent dye, ac- ridine orange [20]. Aliquots of the cell suspension (0.5 mL) that were previously stained with ...
8
The impact of ATP-binding cassette transporters on metabolic diseases
... The macrophage-mediated cholesterol uptake and me- tabolism is associated with the initiation and progression of AS in focal areas of the arterial subendothelial space [40]. The formation of lipid-laden macrophages, also ...
14
Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease
... of lysosomal proteins is ...all lysosomal genes examined contain a palindromic 10 base pair sequence (GTCACGTGAC) in the promoter regions that is a consensus binding site for a basic helix-loop- helix ...
13
Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity
... of lysosomal membrane permeability To evaluate whether the lysosomal membrane permeability was affected by SMA-tDodSNO treatment, acridine orange (AO) staining was ...
17
Search | Preprints
... cargo degradation, lysosomes contain over 50 lysosomal membrane proteins, including an.. 174.[r] ...
25
Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture
... Recently, lysosomal cell death has been defined as “lysosomal membrane permeabilization and the consequent leak- age of lysosome contents into ...lysosome-associated membrane proteins (LAMPs; ...
12
Original Article Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas
... the lysosomal cell death ...through lysosomal membrane permabiliza- tion leading to release of ...inducing lysosomal cell death in the same man- ner as the ...the lysosomal ...
12
Elongated Nanoparticle Aggregates in Cancer Cells for Mechanical Destruction with Low Frequency Rotating Magnetic Field
... that lysosomal membrane permeabilization (LMP) can induce the leakage of lysosomal hydrolases into the cytosol, and lead to cell death eventually ...of lysosomal membrane that contain ...
14
EVALUATION OF IN VITRO ANTI INFLAMMATORYACTIVITY OF ELAEOCARPUS GANITRUS OF BARK EXTRACT BY HRBC MEMBRANE STABILIZATION
... cell) membrane is similar to the lysosomal membrane and the prevention of hypo tonicity induced membrane lysis can be taken as an in vitro measure of anti inflammatory activity of the plant ...
5
Crystal structure of the conserved domain of the DC lysosomal associated membrane protein: implications for the lysosomal glycocalyx
... mal membrane coat were available before this study and the structural basis for the electron microscopical appearance of the coat has remained ...the membrane-proximal domain of human DC- LAMP (LAMP-3) were ...
15
Lysosomal processing of progranulin
... Deletion of cathepsin L, K or Z had no effect on PGRN processing, while ablation of either cathepsin B or D re- sulted in ~50% reduction in the ratio of processed PGRN peptides versus full-length PGRN (Fig. 3a and b). ...
6
Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking
... ionomycin-induced lysosomal exocytosis, indicating that cathepsin D was partially targeted to the lysosome in S1P-KO cells (Fig- ure 2D, ...residual lysosomal targeting of M6P-depen- dent enzymes in S1P-KO ...
18
Original Article Lysosomal integral membrane protein Sidt2 plays a vital role in insulin secretion
... In general, our study confirms that Sidt2, a lyso- somal integral membrane protein, plays a key role in insulin exocytosis via two SNARE pro- teins, synap1 and synap3. Depletion of Sidt2 results in weight loss, ...
10