Major histocompatibility complex class I
Respiratory Syncytial Virus Infection Upregulates NLRC5 and Major Histocompatibility Complex Class I Expression through RIG-I Induction in Airway Epithelial Cells
... lates major histocompatibility complex class I (MHC-I) expres- sion (21–23), although many viruses have the ability to downregu- late MHC-I expression as a strategy for ...
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Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
... pathogens. Major histocompatibility complex class I (MHC-I) molecules play a central role in this defense as reporters of cellular content by presenting peptides derived from ...
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Japanese Encephalitis Virus Utilizes the Canonical Pathway To Activate NF-κB but It Utilizes the Type I Interferon Pathway To Induce Major Histocompatibility Complex Class I Expression in Mouse Embryonic Fibroblasts
... of major histocompatibility complex class I (MHC-I) through the activation of NF- ...Type I interferon (IFN) production was significantly decreased but not completely ...
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The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B*17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication
... D. I. Watkins. 2003. Major histocompatibility complex class I alleles associated with slow simian immunodeficiency virus disease progression bind epitopes recognized by dominant ...
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Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains.
... of major histocompatibility complex class I heavy ...free class I heavy chains are proximal targets for US2-induced degradation, shortly after their ...of class ...
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Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Revealed by Two Peptide Complex Structures and Insights into Immune Escape of Simian Immunodeficiency Virus
... Major histocompatibility complex class I (MHC I)-restricted CD8 ⴙ T-cell responses play a pivotal role in anti-human immunodeficiency virus (HIV) immunity and the control of ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... the major histocompatibility complex (MHC) were named after the discovery that they encode the primary antigens responsible for determining transplant compatibility (Klein 2001), MHC molecules also ...
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Murine cytomegalovirus interacts with major histocompatibility complex class I molecules to establish cellular infection.
... 4182-4189 0022-538X/93/074182-08$02.00/0 Copyright X 1993, American Society for Microbiology JOURNAL OF VIROLOGY, Murine Cytomegalovirus Interacts with Major Histocompatibility Complex C[r] ...
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High Viremia Is Associated with High Levels of In Vivo Major Histocompatibility Complex Class I Downregulation in Rhesus Macaques Infected with Simian Immunodeficiency Virus SIVmac239
... Ex vivo detection of SIVmac239-infected cells. Since wild- type nef sequences were preserved in several rapid progressors, we hypothesized that virus in these animals might downregu- late MHC-I to a greater extent ...
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Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells.
... the class I molecule a 1 domain near residues required for NK cell rec- ognition and near the peptide-binding domain, perhaps ac- counting for studies associating the peptide-binding region with NK cell ...
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Recovery from Friend disease in mice with reduced major histocompatibility complex class I expression.
... We investigated the effects of reduced H-2D& expression on recovery from Friend disease by using H-2b homozygous mice carrying a single P2-microglobulin gene disruption.. These mice had [r] ...
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Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus
... MHC I-dependent antigen presentation reconciles the paradox of efficient induction of CMV-specific CD8 ⴙ CTL in vivo despite extensive potential of CMVs to subvert ...
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Selective Downregulation of Rhesus Macaque and Sooty Mangabey Major Histocompatibility Complex Class I Molecules by Nef Alleles of Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2
... MHC class I molecules ...MHC class I tail se- quences were infected with HIV-1 NL4-3-based vectors that ex- press enhanced green fluorescent protein (eGFP) alone or to- gether with the Nef ...
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A Noncanonical mu-1A-Binding Motif in the N Terminus of HIV-1 Nef Determines Its Ability To Downregulate Major Histocompatibility Complex Class I in T Lymphocytes
... Analysis of the importance of the N-terminal region of Nef for MHC-I downregulation. A basic cluster (Arg17, -19, -21, and -22) is relatively conserved among Nef proteins of various HIV-1 subtypes. It has been ...
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Human Cytomegalovirus Disrupts the Major Histocompatibility Complex Class I Peptide-Loading Complex and Inhibits Tapasin Gene Transcription
... MHC I was determined by MAb W6/32 throughout the HB5 replication ...MHC I than control MRC-5 cells ...MHC I trafficking to the cell ...MHC I was consistently induced in the tapasin-expressing ...
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Definition of Five New Simian Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitopes and Their Restricting Major Histocompatibility Complex Class I Molecules: Evidence for an Influence on Disease Progression
... MHC class I molecules that restrict virus- specific CTL responses in SIV- or simian/human immunode- ficiency virus-infected rhesus macaques have been identified (1, 2, 14, 16, 30, 44, ...MHC class ...
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Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions
... Endogenous peptides presented by MHC-I molecules (called MHC-I peptides (MIPs) or the immunopepti- dome) represent the key to self/non-self-discrimination by cells of the immune system. In this respect, a ...
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A major histocompatibility complex class I related Fc receptor for IgG on rat hepatocytes
... a major histocompatibility complex (MHC) class I-like Fc receptor, or FcRn, which transports IgG in an apical to basolateral ...MHC class I transcripts, FcRn DNA was ...
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Evolutionary Relationships of Major Histocompatibility Complex Class I Genes in Simian Primates
... likely, but uncertain. Subsequently, proto-B and -G genes expanded to generate five group B and five group G genes, respectively, and there were at least eight gene duplications during phase I. On the other hand, ...
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Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity
... MHC class I expression was measured with a conformationally dependent monoclonal antibody, ...MHC class I expression compared with PBLs from normal volunteers and non-insulin- dependent ...
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