Major histocompatibility complex class I molecule
Expression of the Major Histocompatibility Complex Class I Molecule Mamu-A*01 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication
... immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule Mamu-A*01: implications for vaccine ...
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Antiviral protective immunity induced by major histocompatibility complex class I molecule-restricted viral T-lymphocyte epitopes inserted in various positions in immunologically self and nonself proteins.
... virus-specific major histocompatibility complex class I molecule-restricted T-cell epitopes and proteins not related to LCM virus into BALB/c and also B6, CB6F1, and NMRI mice ...
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Identification of the mouse cytomegalovirus genomic region affecting major histocompatibility complex class I molecule transport.
... Construction of a HindIII-E deletion mutant of MCMV. The next goal was to link the MHC class I redistribution phenotype in DNA-injected cells with an altered phenotype of a recom- binant virus deleted for ...
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Major histocompatibility complex class I molecule expression is normal on peripheral blood lymphocytes from patients with insulin dependent diabetes mellitus
... MHC class I molecule expression on the cell surface of freshly iso- lated splenic lymphocytes from prediabetic NOD/Lt mice ...MHC class I molecule expression on T cells from NOD ...
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Dominance of CD8 Responses Specific for Epitopes Bound by a Single Major Histocompatibility Complex Class I Molecule during the Acute Phase of Viral Infection
... We infected eight Mamu-A*01-positive macaques and five Mamu-A*01-negative macaques with the molecularly cloned virus SIVmac239 and determined all of the simian immunodeficiency virus-spe[r] ...
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Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Revealed by Two Peptide Complex Structures and Insights into Immune Escape of Simian Immunodeficiency Virus
... MHC I Mamu-A*02 ...MHC I Mamu-A*02/YY9, represented by molecule 1 in the asymmetric ...MHC I Mamu-A*02 (green) with those of Mamu-A*01 (brown) (PDB code ...of major conformational ...
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Requirements for the Selective Degradation of Endoplasmic Reticulum-Resident Major Histocompatibility Complex Class I Proteins by the Viral Immune Evasion Molecule mK3
... mK3 molecule of gammaherpesvirus 68, although re- lated to other K3 family members in terms of domain organi- zation, differs with respect to its site of ...surface class I expression by targeting ...
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<p>Major histocompatibility complex class II molecule in non-small cell lung cancer diagnosis, prognosis and treatment</p>
... MHC class I would assist cancer cells escape from speci fi c cytotoxic T cells mediated cytolysis, 24 MHC class I was considered an important part in antitumor ...MHC class II to present ...
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Herpes Simplex Virus (HSV)-Mediated ICAM-1 Gene Transfer Abrogates Tumorigenicity and Induces Anti-Tumor Immunity
... Expression of the adhesion molecule ICAM- 1 and major histocompatibility complex class I antigens on human tumor cells is required for their inter- action with autologous lymphocytes in [r] ...
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Human Cytomegalovirus Protein US2 Interferes with the Expression of Human HFE, a Nonclassical Class I Major Histocompatibility Complex Molecule That Regulates Iron Homeostasis
... ures, lysed (0.5% Triton X-100 in lysis buffer), and immuno- precipitated with the relevant Abs. Immunoprecipitation with anti-hHFE (2F5) revealed that this MAb recognizes an epitope present on hHFE/2m heterodimers ...
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Identification of Major Histocompatibility Complex Class I C Molecule as an Attachment Factor That Facilitates Coronavirus HKU1 Spike-Mediated Infection
... HLA class I molecules, encoded by the major histocompat- ibility complex (MHC), are ubiquitously expressed on all human nucleated cells and function as highly specialized antigen- presenting ...
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Viral Proteins Interfering with Antigen Presentation Target the Major Histocompatibility Complex Class I Peptide-Loading Complex
... MHC-I molecule binds to calreticulin ...MHC-I molecule may have already acquired a peptide able to induce final maturation; alternatively, the MHC-I may be from a HLA allele less prone ...
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Human Herpesvirus 7 U21 Tetramerizes To Associate with Class I Major Histocompatibility Complex Molecules
... of class I MHC molecules to lysosomes, the simplest is one exemplified by the MCMV m06 immunoevasin ...m06-class I MHC complex to the lysosomal compartment ...of class I ...
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Major histocompatibility complex class I antigens and the control of viral infections by natural killer cells.
... other class I molecules protected the C1R cells from NK cells, and exon-shuffling and point mutation studies indicated that a region near the pep- tide-binding domains of the class I ...
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TARGETING TOOLS FOR A DNA VACCINE CARRIER, A DESIGN IN PREVENTION OF CANCER
... For a successful vaccination, usually dendritic cells play a great role as APC (antigen presenting cell) to activate naïve CD4 T-Cell and CD8 T-Cell, thereby Immunization against disease. Recent decade molecular medicine ...
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HLA C and HIV 1: friends or foes?
... The major histocompatibility complex class I protein HLA-C plays a crucial role as a molecule capable of sending inhibitory signals to both natural killer (NK) cells and ...
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The Simian Immunodeficiency Virus Envelope Glycoprotein Contains Two Epitopes Presented by the Mamu-A*01 Class I Molecule
... this class I major histocompatibility complex molecule was required for target cell recognition by envelope-specific CD8 ⴙ T cells directed against both ...
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Differential expression of major histocompatibility complex class I in developmental glioneuronal lesions
... All labeled tissue sections were evaluated by two inde- pendent observers blind to clinical data, for the presence or absence of various histopathological parameters and specific immunoreactivity for the different ...
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Vesicular stomatitis virus infection of the central nervous system activates both innate and acquired immunity.
... the CNS. As early as 3 days p.i., expression of iNOS was detected in microglial cells in the OB. Increased level of iNOS expression coincided with decreased virus titers. In light of the inhibition of VSV production in ...
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Altered Expression of TAP-1 and Major Histocompatibility Complex Class I in Laryngeal Papillomatosis: Correlation of TAP-1 with Disease
... that class I major his- tocompatibility complex (MHC-I) antigen can be variably down-regulated in RRP (1), which is consistent with reports of MHC-I antigen down-regulation in ...
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