Major Histocompatibility Complex Loci
Polymorphism and balancing selection at major histocompatibility complex loci.
... Theory suggests that the number of alleles that differ at the sites targeted by selection (presumably the nonsynonymous sites in the PBR) should be equal to the [r] ...
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Signatures of Demographic History and Natural Selection in the Human Major Histocompatibility Complex Loci
... of loci (G oldstein and C hikhi ...HLA loci is unlikely to be accounted for by the demographic history of ...HLA loci, resulting in signifi- cant associations between loci separated by large ...
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Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis
... genetic loci have been shown to confer risk for ...The major histocompatibility complex (MHC) harbours the psoria- sis susceptibility region which exhibits the largest effect size, driven in ...
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Allelic genealogy under overdominant and frequency-dependent selection and polymorphism of major histocompatibility complex loci.
... out at the present time, because there are no experi- mental data against it. It is to examine the fitness of a homozygote for a rare allele at a locus. If minority advan[r] ...
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Sampling strategies for accurate computational inferences of gametic phase across highly polymorphic major histocompatibility complex loci
... Findings: Analyses carried out over real MHC genotypes showed that the accuracy of gametic phase reconstruction improved with sample size as a result of the reduction in the allele to individual ratio. We then simulated ...
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An assessment of genetic diversity and inbreeding in the Noisy Scrub-bird (Atrichornis clamosus) using microsatellite and Major Histocompatibility Complex loci
... microsatellite loci highlighted the low genetic diversity across all populations, with a marginally higher allelic diversity in the original remnant population than in the two derived ...of loci, with just ...
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Genetic Variation of Major Histocompatibility Complex and Microsatellite Loci: A Comparison in Bighorn Sheep
... When we did calculate repeat size-based genetic distances (assuming a dinucle- otide repeat) for this locus, values averaged -400 for comparisons between populations in the [r] ...
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MHC (MAJOR HISTOCOMPATIBILITY COMPLEX)
... three major classes: class I, class II and class ...MHC complex resides in the short arm of chromosome 6 and overall size of the MHC is approximately ...gene complex contains three loci A, B ...
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GLUCOCORTICOID-INDUCED CLEFT PALATE IN THE MOUSE: TWO MAJOR HISTOCOMPATIBILITY COMPLEX, H-2, LOCI WITH DIFFERENT MECHANISMS
... Methods included (1) computation of regression with more than one value of Y (the arcsine for each litter) with an unequal sample size of litters for each grou[r] ...
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Conditional analysis of the major histocompatibility complex in rheumatoid arthritis
... significant association was p = 5.3 × 10 -6 for PTPN22. Clearly, the MHC is the most influential genetic region in RA susceptibility, but extensive LD makes isolating the precise loci difficult. We have used ...
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The Implications of Intergenic Polymorphism for Major Histocompatibility Complex Evolution
... variation at the DIST or FGF loci. At the other extreme, tion size is too high or too large to be compatible with the TNF locus shows variation that is only slightly above the nucleotide diversity at other neutral ...
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Major Histocompatibility Complex Variation in the Endangered Przewalski’s Horse
... addition, MHC genes have been suggested as important In fact, because of the high variability within loci and in mate selection and maternal-fetal interaction (e.g., the similarity of alleles between loci, ...
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The Major Histocompatibility Complex Class I Genes of Zebrafish.
... The initial full-length Z transcripts from zebrafish were named Dare-ZE*0101 and Dare-ZE*0102 not knowing if they represented different genes or different alleles of a single gene (Kruiswijk et al. 2002). However, it was ...
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Major Histocompatibility Complex Differentiation in Sacramento River Chinook Salmon
... because microsatellite loci are generally selectively neu- Hedrick 1994). Recently, there have been a number tral, they may not adequately describe adaptive differ- of reports describing MHC variation in fishes ...
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Major Histocompatibility Complex (MHC) Genes and Disease Resistance in Fish
... Fig. 2. Alignment of deduced classical MHC class I 1+2 domain amino acid sequences. This figure is dedicated to showing aspects of within species variation in the most important functional parts of the classical MHC ...
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Gene duplication and fragmentation in the zebra finch major histocompatibility complex
... Phylogenetic analyses highlight the clustering of Class IIB loci by species rather than by orthology relation- ships, suggesting a history of concerted evolution, at least on portions of the genes [38,60,61]. We ...
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Major Histocompatibility Complex Heterozygosity Reduces Fitness in Experimentally Infected Mice
... background loci implies that congenic models may be overly simplified to capture the complex and unpredict- able mode of genetic determination of resistance in natural ...
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George Snell's First Foray Into the Unexplored Territory of the Major Histocompatibility Complex
... H2 m allele derived from the N strain. And finally, if the nary polymorphism of its loci—became the raison d’eˆtre for the surge of interest in the Mhc. First, the surgeons, rejection of the tumor transplant were ...
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Major histocompatibility complex haplotype diversity in Arab horses from Argentina
... La representación esquemática del mapa de los tres STRs en relación al MHC se muestra en la Figura 1. Tipificación y polimorfismo de los STRs La tipificación de los microsatélites fue realiza- da en un total de 30 ...
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Characterization of the major histocompatibility complex locus association with Behçet’s disease in Iran
... 6. Lee YJ, Horie Y, Wallace GR, Choi YS, Park JA, Choi JY, et al. Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet ’ s disease. Ann Rheum Dis. 2013;72:1510 – 6. 7. Hughes T, Coit ...
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