Male germ cell development
Identifying disruptors of male germ cell development by small molecule screening in ex vivo gonad cultures
... of male germ cell mitotic arrest were SB431542 and PD0325901, which inhibit the ACTIVIN/TGFβ/NODAL receptors ALK4, ALK5 and ALK7, and MEK1/2 signaling, ...the germ cell population in- ...
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Functional redundancy among Nanos proteins and a distinct role of Nanos2 during male germ cell development
... PGC development and that Nanos2 is required for male germ cell development in the mouse (Tsuda et ...during male germ cell development (Tsuda et ...embryonic ...
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Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors
... Testicular germ cell tumors (TGCT) encompass a broad group of cancers, each displaying different levels of pluripotency and differentiation as well as malignancy ...TGCT cell of origin is thought to ...
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Postnatal epigenetic reprogramming in the germline of a marsupial, the tammar wallaby
... during male germ cell development in the tammar, we first determined when the demethylation occurs in tammar PGC development by analysis of the PEG10 and H19 DMR, an LTR of KERV-1 and ...
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Characterization of eight novel proteins with male germ cell-specific expression in mouse
... Male germ cell development involves successive mitotic (spermatogonia), meiotic (spermatocyte) and postmei- otic phases (spermatids). Spermatogonial stem cells, located around the outer region ...
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The male reproductive system of Hippolyte inermis Leach 1815 (Decapoda, Caridea)
... the male reproductive system (testes, vasa deferentia, gonopores) and the different stages of male germ cell development are described for the first time in the genus Hippolyte, using ...
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Differentiation of mouse primordial germ cells into female or male germ cells
... ectopic germ cells in the mesonephroi or adrenal cortex (Zamboni and Upadhyay, 1983; Francavilla and Zamboni, 1985) suggested that both male and female PGCs show cell-autonomous entry into meiosis if ...
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Spermiogenesis and Male Fertility Require the Function of Suppressor of Hairy-Wing in Somatic Cyst Cells of Drosophila
... Using cell-type-specific tools to restrict Su(Hw) ex- pression, we demonstrate that the essential spermatogenesis function of Su(Hw) resides in somatic cyst cells, not in germ ...
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The polyubiquitin gene Ubi p63E is essential for male meiotic cell cycle progression and germ cell differentiation in Drosophila
... through development are not ...required cell-autonomously for proper meiotic chromatin condensation, cell cycle progression and spermatid ...mutant germ cells develop normally to the ...
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Endocrine disruptors, gene deregulation and male germ cell tumors
... testis development and germ cell differentiation with different mechanisms and diverse molecular pathways, as shown by their patterns of gene expression ...of development, since in an ...
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Src64 controls a novel actin network required for proper ring canal formation in the Drosophila male germline
... organisms, germ cells develop as cysts in which cells are interconnected via ring canals (RCs) as a result of incomplete ...developing germ cells. We also identify that Src64 is required for proper ...
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DAZ Family Proteins, Key Players for Germ Cell Development
... in cell lines is microtubule-dependent and a selected number of DAZL -bound mRNAs could accumulate in the perinuclear area ...within germ cells and/or be involved in the localization of repressed mRNA to ...
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A germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans
... germline development and becomes essential for germ cell development in the absence of nos-1 and ...for germ cell differentiation than had previously been ...controlling ...
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Regulation of primordial germ cell development in the mouse
... The main goal of the early experiments carried out in the Anne McLaren´s laboratory at the MRC Developmental Unit in London was to develop a method for the isolation and purification of mouse PGCs at different ...
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Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells
... between germ cells within an individual cyst as well as adhesion between germ cell and follicle cell ...within germ cells to regulate E-cadherin ...at germ cell or ...
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The role of germ cell loss during primordial follicle assembly: a review of current advances
... marked germ cells to be detected during development and found that following labeling at ...the germ cell clones (100 %) contained labeled cells in one, two, four or eight cell ...
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The function and regulation of vasa like genes in germ cell development
... in germ cells were identified in many species, including mouse, rat, frog, zebrafish, medaka (Oryzias latipes), trout, planarian, chick, ascidian, nematode, silkworm, human and the flour beetle (Table 1; ...
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Arginine methylation of SmB is required for Drosophila germ cell development
... chamber development, GFP-SmB predominantly accumulated in the nuclei of nurse cells and oocyte ...nurse cell nuclei and was present in the cytoplasm of the ...
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Germ cells and germ cell transplantation
... When germ cells were harvested from mouse genital ridges with minimal somatic cell contamination (De Felici and McLaren, 1982) and cultured in plastic dishes (De Felici and McLaren, 1983), those taken from ...
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A model for germ cell development in a fully segmented worm
... In 3-segmented nectochaete worms (6 days post fertilization, dpf), Pn-vasa was detected in the parapodia on both sides of segments I and II, at the exact place where the Pn-vasa -positive cells were found closer to the ...
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