Mammalian Cochlea
A study of in situ outer hair cells from the adult mammalian cochlea
... Variations in the expression of OHC potassium conductances along the tonotopic gradient of the adult mammalian cochlea have been investigated (Housley and Ashmore, 1992; Mammano and Ashmore, 1996). However, ...
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Otx2 is a target of N myc and acts as a suppressor of sensory development in the mammalian cochlea
... the cochlea and to control correct patterning of the organ of ...a mammalian ortholog of the Drosophila orthodenticle homeobox gene, is a crucial target of N-myc during inner ear ...
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Electrical properties of Deiters cells of the mammalian cochlea
... In the absence of 1-octanol, the gap-junctional resistance appeared to be too low to allow a discrete treatment, and a continuous two-dimensional sheet model was formulated. For three separate preparations, a linear ...
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Hedgehog signaling regulates prosensory cell properties during the basal to apical wave of hair cell differentiation in the mammalian cochlea
... Fig. 3. Deformity of hair cell rows in the apical part of Smo CKO cochleae. (A) Hair cell number per 100 μm determined by counting hair cells along a 200 μm cochlear length located at positions 25%, 50% and 75% of P7 Smo ...
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A dual function for canonical Wnt/β catenin signaling in the developing mammalian cochlea
... Comparable to that reported for retinal progenitor cells (Agathocleous et al., 2009), continuous Wnt/-catenin activation in the cochlea upregulates Sox2 and confers a more progenitor-like character. We observed ...
11
FM1-43 reveals membrane recycling in adult inner hair cells of the mammalian cochlea
... the cochlea were imaged with a two-photon confocal laser-scanning micro- scope that consisted of an MRC 1024 scan head (Bio-Rad, Hemel- Hempstead, UK) mounted on a Nikon FN 600 upright ...
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Epigenetic regulation of Atoh1 guides hair cell development in the mammalian cochlea
... Perinatal supporting cells retain a poised epigenetic state In non-mammalian vertebrates, supporting cells undergo robust transdifferentiation in response to hair cell death (Ku et al., 2014; Stone and Cotanche, ...
9
Active traveling wave in the cochlea
... In this letter it has been our aim to provide a concise, coherent interpretation of a wide variety of observations, rather than a detailed fit of individual data. Consider- ing that our model incorporates only one free ...
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Sox2 haploinsufficiency primes regeneration and Wnt responsiveness in the mouse cochlea
... neonatal mammalian cochlea can also occur without an antecedent mitotic event (43, 45), through the direct transition of supporting cells into hair ...embryonic cochlea and is rapidly downregulated ...
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Original Article Spatiotemporal expression of Bmi1 in the developing mouse cochlea
... The mammalian cochlea is a complex sensory organ that is responsible for sound detection, and it contains two types of auditory hair cells (outer hair cells and inner hair cells) and at least four types of ...
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Sensory hair cell development and regeneration: similarities and differences
... chick cochlea showed that treatment with γ -secretase inhibitors increases the number of regenerated hair cells, in this context via both mitotic and non-mitotic mechanisms (Daudet et ...(immature) ...
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Wbp2 is required for normal glutamatergic synapses in the cochlea and is crucial for hearing
... We demonstrate for the first time a direct link between the Wbp 2 mutation and progressive hearing loss. Wbp 2 -deficient mice show progressive high-frequency hearing loss due to a primary synaptopa- thy. The lack of ...
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Bats, Primates, and the Evolutionary Origins and Diversification of Mammalian Gammaherpesviruses
... among mammalian ␥ HV ...6 mammalian viral lineages FIG 1 The phylogeny of gammaherpesviruses based on a 564-residue-long alignment of the glycoprotein B (gB) ...81 mammalian ␥ HV sequences, including ...
9
A “Tric” to tighten cell cell junctions in the cochlea for hearing
... TJs were not integrated into typical tTJs at the center of TC regions. A similar pheno- type was seen at the TCs in the utricular macula (vestibular organ). These obser- vations clearly demonstrate that tricel- lulin is ...
5
Towards a better understanding of cochlear mechanics: A new cochlear model
... The purpose of modelling cochlear mechanics is to gain a better understanding of the operation of the real cochlea by the formulation and analysis of models that reflect the structure an[r] ...
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To a new hardware design methodology: A case study of the cochlea model
... the cochlea. The cochlea is the auditory portion of the inner ear and a lot of research has previously been done on obtaining accurate mathematical models of the ...dimensional cochlea model with ...
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Calcium signaling in the cochlea - Molecular mechanisms and physiopathological implications
... The cochlea is the snail–shaped inner ear structure where auditory processing is initiated. Different regions of the cochlear basilar membrane vibrate at different si- nusoidal frequencies due to variations in ...
12
Neurosensory development and cell fate determination in the human cochlea
... W19 cochlea, all IHCs and OHCs had become negative for both SOX2 and SOX9, in contrast to the supporting cells in the OC and in some of the adjacent cells in Kölliker’s organ, which expressed SOX2 (Figure 2J,K), ...
14
Unbiased Characterization of Anopheles Mosquito Blood Meals by Targeted High-Throughput Sequencing
... multiple mammalian hosts in a single blood ...the mammalian mitochondrial 16S ribosomal RNA genes (16S rRNA) should amplify more than 95% of the mammalian 16S rRNA sequences present in the NCBI ...
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Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo
... neonatal cochlea are competent to form new HCs in culture (Chai et ...adult cochlea, suggesting that the neonatal cochlea is a more permissive environment for the formation of new ...
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