mammary stem cell
Re evaluation of mammary stem cell biology based on in vivotransplantation
... myoepithelial cell types in keeping with the pluripotent nature of the lineage-limited ...pluripotent mammary cells other than the primordial mammary stem cell can be targets for ...
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MicroRNA 205 signaling regulates mammary stem cell fate and tumorigenesis
... KD stem cells switched the SDi phenotype to a predominant AD phenotype (Figure 5, A and ...ric cell division through transcriptional regulation of polarity protein ...
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An essential role of CBL and CBL B ubiquitin ligases in mammary stem cell maintenance
... luminal progenitors (CD29 low CD61 + ), mature luminal cells Fig. 1. Impaired mammary gland (MG) development in Cbl/Cbl-b DKO mice. (A) Carmine alum-stained whole-mounts of Cbl/Cbl-b DKO, CblKO and Cbl-bKO virgin ...
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Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation
... cancer stem cell theory proposes that only a small subset of cells, the tumour initiating cells, can seed a new tumour or a metastasis ...cancer stem cells in order to identify pathways and targets ...
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Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesis
... of mammary development and breast cancer ...in mammary epithelial cells remains ...induces mammary tumorigenesis by increasing normal and malignant mammary stem cell (MaSC) ...
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Stem Cell Research: A Novel Boulevard towards Improved Bovine Mastitis Management
... adult stem cells and trying to discover better ways to grow huge quantities of adult stem cells in laborato- ries and to manipulate them to generate specific cell types (as per need), and ...
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Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer
... of mammary epithelial lineages [40], we hypothesized that epithelial subpopulations may be altered in mice undergoing ...of stem and progenitor cells is well-defined for mouse mammary epi- thelium ...
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Enrichment of breast cancer stem-like cells by growth on electrospun polycaprolactone-chitosan nanofiber scaffolds
... breast-cancer stem-like cells (BCSC), express markers similar to mammary stem cells, and are highly resistant to ...and stem-like properties of breast cancer cell lines grown on ...
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Role of Notch signaling in cell fate determination of human mammary stem/progenitor cells
... promotes mammary stem cell ...of stem/ progenitor cells also occurs in the mammospheres, as demonstrated by an increased size of the primary and sec- ondary mammosphere diameter in the ...
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Resident macrophages influence stem cell activity in the mammary gland
... the mammary stem cell niche is yet to be defined but candidate cell types that may constitute the niche include epithelial cells, macrophages and eosinophils, among other cells in the ...
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Mammary gland-derived nestin-positive cell populations can be isolated from human male and female donors
... of stem/progenitor cells from mammary glands via cell sorting has been investigated and discussed in the literature ...human mammary stem or progenitor populations were reviewed by ...
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The mammary myoepithelial cell
... of cell-cell interactions in the mammary epithelium has been provided by Hinck’s ...basal-luminal cell adhesion and crosstalk. In the mammary epi- thelium, Netrin1, a secreted guidance ...
9
The complexity of TRIM28 contribution to cancer
... ES cell in a phosphorylation-dependent ...embryonic stem cells by Sumo2 in order to establish provirus silencing through the canonical Zfp809/Trim28/ Eset machinery [92] which ultimately safeguards ESC gen- ...
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20_Lecture_Presentation_PC.ppt
... Figure 20.19a Mammary cell donor 2 1 3 TECHNIQUE Cultured mammary cells Egg cell from ovary Egg cell donor Nucleus removed Cells fused Nucleus from mammary cell.. RESULTS[r] ...
127
Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial mesenchymal transition
... demonstrate, using a bitransgenic mouse model, that misexpression of human Six1 in adult mouse mammary gland epithelium induces tumors of multiple histological subtypes in a dose-dependent manner. The neoplastic ...
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Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
... lar cell differentiation during pregnancy [36] but may play an earlier role in regulating luminal cell-fate ...human mammary epithelial cell ...
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Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias
... Loss of the STAT1 downstream transcription factor IRF1 has been reported in MIN cases of human breast cancer [21]. Moreover, the loss of heterozygosity at the IRF1 gene locus has been found to be a frequent event in ...
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Embryonic cells contribute directly to the quiescent stem cell population in the adult mouse mammary gland
... The cell suspension was then filtered through a 40-micron mesh and labeled with various antibodies for further ...activated cell sorting (FACS) (MoFlo, BD Bioscience, San Jose, CA, USA) for these ...
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KISS1R Induces Human Mammary Epithelial Cell Invasiveness and Promotes Breast Cancer Cell Migration and Invasion via IQGAP1
... human mammary epithelial cell (hMEC) cultures it has been demonstrated that even partial suppression of BRCA1 function induced EGFR expression and an increase in EGFR-positive cancer stem-like cells, ...
140
Evidence that GTP binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial to mesenchymal transition in mammary epithelial cells
... Previously, we reported that TG2 expression in MCF10A cells disrupts their normal organization into acinar structures when grown in three-dimensional cul- ture [7]. We next sought to determine whether catalytic inactive ...
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