MAP kinase/ERK kinase 1
Role of the stress activated protein kinases in endothelin induced cardiomyocyte hypertrophy
... stress-response MAP kinase, p38, by over- expression of activated mutants of various components of the pathways is sufficient to induce a hypertrophic response in cardiomyocytes, but it is not clear what ...
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Eimeria bovis-triggered neutrophil extracellular trap formation is CD11b-, ERK 1/2-, p38 MAP kinase- and SOCE-dependent
... 488, 1:100; ab139848, Abcam], anti-MPO anti- bodies (rabbit anti-bovine MPO, Alexa Fluor 488, 1:200; ABIN906866) and anti-NE antibodies (rabbit anti-human NE, 1:200; AB68672, ...
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Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury
... and ERK are known to play important roles as upstream regulators of the induced expression of inflam- matory mediators in response to cytokines, stress, and cytoskeletal reorganization ...these MAP kinases ...
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Localization of ERK/MAP Kinase Is Regulated by the Alphaherpesvirus Tegument Protein Us2
... the MAP kinases ERK1 and ERK2 in ...the MAP kinase ERK1 were identified in the ...1B). ERK interacts with Us2 in infected cells and is packaged into virions in a Us2-dependent ...whether ...
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Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin
... with ERK/MAP kinase signaling. Increased phosphorylation of ERK is indicative of signal- ing through the MAP kinase ...NPCs, ERK signaling is crucial for carbachol-induced ...
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Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6
... protein kinase; MKK: MAP kinase kinase; JNK: cJun N-terminal kinase; BMDM: Bone marrow derived macrophages; IL-10: Interleukin 10; WT: Wild type; SB: SB203580 (p38 α / β inhibitor); SP: ...
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Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite
... within 1 hour, reaching a maximum at 5 hours ...active ERK by western analysis of dissected somites at the same time points ...for 1 hour to FGF4, the levels of dual phosphorylated ERK were ...
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Brfl Post-Transcriptionally Regulates Pluripotency and Differentiation Responses Downstream of Erk MAP Kinase
... Embryonic stem cells (ESCs) hold great promise for the development of novel therapeutic strategies (1). Owing to their capacity for multi-lineage differentiation, diseased or damaged tissues can be replaced ...
89
Requirement for ERK MAP kinase in mouse preimplantation development
... These analyses suggested the possibility that inhibition of cell-cell adhesion, similar to inhibition of the ERK pathway, might induce cell cycle arrest in four-cell-stage embryos. To test this possibility, we ...
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Selective activation of the mitogen activated protein kinase subgroups c Jun NH2 terminal kinase and p38 by IL 1 and TNF in human articular chondrocytes
... rosine kinase activation was required for the expression of a broad spectrum of IL-1 inducible genes in human articular chondrocytes (30, ...as MAP ki- nases ERK-1 and ...of ...
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p38 MAP kinase modulates liver cell volume through inhibition of membrane Na+ permeability
... tyrosine kinase activity is also important in the response to cell volume changes (58, 59), and Src tyrosine kinase has been shown to be a direct regulator of ion channel function in different cell types ...
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Human Endotoxemia Activates p38 MAP Kinase and p42/44 MAP Kinase, But Not c-Jun N-terminal Kinase
... Fig. 1. LPS activates p38 MAPK, p42/44 MAPK and JNK in PBMCs and non-PBMCs in vitro. PBMCs and non-PBMCs were isolated from whole blood, incubated for 45 min at 37 C, and stimulated with LPS for 15 min at the ...
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Development of a pooled probe method for locating small gene families in a physical map of soybean using stress related paralogues and a BAC minimum tile path
... Among the ESTs that we found in the unique gene family were homologous to known genes G-box binding factor, epoxide hydrolase, chalcone synthase, and phenyl alanine ammonia lyase 1 (PAL1). Southern hybridizations ...
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Response of Mammalian Macrophages to Challenge with the Chlorovirus Acanthocystis turfacea Chlorella Virus 1
... virus 1, family Phycodnaviridae) and that these study subjects had decreases in visual processing and visual motor speed compared with individuals in whom no virus was ...and ERK mitogen-activated protein ...
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Heparin Inhibits Proliferation and Migration of Patient-Derived Vascular Cells Only at Non-physiological Concentrations Due to Antagonistic Pathways
... Heparin inhibits proliferation and migration in patient-derived VSMC cultures, but only at concentrations exceeding clinical doses. The proliferative response of VSMCs to heparin was not affected by the presence of ECs. ...
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Reassessment of the v-fms sequence: threonine phosphorylation of the COOH-terminal domain.
... Substrate consensus sequences for cdc2 kinase and other kinases Recognition motif' cdc2 kinase Proline-directed protein kinase ERK/MAP kinase Growth factor-regulated kinase ERK/MAP kinas[r] ...
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Tumour necrosis factor activates the mitogen activated protein kinases p38α and ERK in the synovial membrane in vivo
... Heterozygous Tg197 human TNF-α transgenic (hTNFtg) mice (strain C57/Bl6), which develop a chronic inflammatory and destructive polyarthritis within 4–6 weeks after birth, were described previously [7]. We investigated ...
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Original Article Tumor suppressor BLU exerts growth inhibition by blocking ERK signaling and disrupting cell cycle progression through RAS pathway interference
... by ERK and other MAPK family ...dependent kinase (CDK) complex [27, for a review see 28]; groups D and B cyclins function to promote transition of G1/S and G2/M phases in cell cycle ...of ERK pathway ...
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Supplementing L-isoleucine increases medium protein and alters the expression of genes and proteins involved in milk protein synthesis and energy metabolism in bovine mammary cells
... The mTOR, a protein kinase present in the rapamycin-sensitive mTOR complex 1 (mTORC1) [10] partly mediates the stimulation of protein synthesis by AAs (Kim, 2009). The mTOR pathway centers around mTORC1 ...
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“Docking Studies on Eupalitin-3-O-β-D-galactopyranoside as Potential Inhibitor of Cyprinus carpio (KOI CARP) MAPK/ERK Kinase 2 and Mitogen-Activated Protein Kinase (p38)” by Kader Asen Fathima, Chetancherry Somasundaram Parameswari, India.
... MEK1. Val211 and Leu215 form van der Waals interactions with the C-ring of Quercetin. The hydroxyl group at the 3′ position of the C-ring can make a critical hydrogen bond with the backbone amide group of Ser212. These ...
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